NEXT GENERATION CANCER MODELS (NON CMDC) MOLECULAR CHARACTERIZATION AND CLINICAL DATA COLLECTION

该项目的目的是资助分布模型的分子表征，这些模型可能没有完整的注释(例如，亲本肿瘤和有时正常可能丢失)，将增加模型的数量，这些模型将具有15X的全基因组测序、150X的全外显子测序、转录组测序和表观遗传学表征，即模型将具有与CMDC生成的模型相同的数据。对于可以获得临床数据的模型，也将收集这些数据(在不同的机制下收集)。这将增加可用于大规模筛查研究的模型数量，通过开发的分发管道增加可用肿瘤亚型的数量，并以适度的投资扩大NCI向社区提供的模型数量。据估计，通过这条管道将增加多达200个NGCM。

The purpose of the project is to fund the molecular characterization of models for distribution that probably would not have as complete annotation (e.g. the parent tumor and sometime normal could be missing), would increase the number of models that would have whole genome sequencing at 15X, whole exome sequencing at 150X, transcriptome sequencing and epigenetic characterization, i.e. the models would have the same data as are available for CMDC generated models. For the models for which clinical data is available, it would be collected as well (collected under a different mechanism). This would increase the number of models available for large scale screening studies, increase the number of tumor subtypes available through the developed distribution pipeline and for a modest investment enlarge the number of models that NCI provides to the community. It is estimated that up to 200 NGCMs would be added through this pipeline.