课题基金 / 基金详情

Focal ultrasound-mediated nonthermal ablation of brain tumors

Focal ultrasound-mediated nonthermal ablation of brain tumors
局灶超声介导的脑肿瘤非热消融
批准号:
10346714
负责人:
Tyrone Porter
金额:
$19.67万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-08-01 至 2023-05-31

项目摘要

项目成果

Tyrone Porter的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
PROJECT SUMMARY Glioblastoma multiforme (GBM) is the most common and aggressive primary human brain tumor and is invariably fatal. Standard of care includes debulking of tumor, normally through surgery; however, not all GBM tumors or patients are eligible for the procedure. Ablation is an effective alternative to surgical resection, and can be performed noninvasively with transcranial focused ultrasound. In the proposed project, transcranial focused ultrasound will be combined with a novel phase-shift nanoemulsion (PSNE) for focal nonthermal ablation of GBM tumors. PSNE can be vaporized with ultrasound pulses and the resultant bubbles can generate intense mechanical forces that can collapse blood vessels or fractionate tissue. Vaporization of the nanoemulsions selectively in established GBM tumors will enable highly localized nonthermal ablation of intracranial tumors while sparing surrounding healthy brain tissue. To test this premise, we will evaluate the extent of damage and immune response to ablation (i.e. immune cell infiltration) within and adjacent to sonicated brain tumors as a function of acoustic pressure and PSNE concentration. We will also analyze ablated regions for expression of ceramide, an apoptotic promoter that reportedly enhances the efficacy of radiotherapy by more than 10-fold. Lastly, we will assess the impact of nonthermal focal ablation on the survival of tumor-burdened rats. Overall, we aim to elucidate the parameters that facilitate safe and effective ultrasound-mediated nonthermal ablation of primary brain tumors.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Emerging Therapeutic Strategies for Brain Tumors.
脑肿瘤的新兴治疗策略。
DOI: 10.1007/s12017-021-08681-z
发表时间: 2022
期刊: Neuromolecular medicine
影响因子: 3.5
作者: [Aryal,Muna, Porter,Tyrone]
通讯作者: Porter,Tyrone
Enhancing ultra-sound-mediated tumor ablation with phase-shift nanoemulation
Enhancing ultra-sound-mediated tumor ablation with phase-shift nanoemulation
Enhancing ultra-sound-mediated tumor ablation with phase-shift nanoemulation
Neutral pressure-sensitive nanoemulsion for localized siRNA delivery
国内基金
海外基金
LIPUS促进微环境巨噬细胞释放CCL2诱导尿道周围平滑肌祖细胞定植与分化的机制研究
  • 批准号:
    82370780
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    夏术阶
  • 依托单位:
超声多信号融合高浓度液固/液液两相流在线测量方法研究
  • 批准号:
    50706029
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2007
  • 负责人:
    苏明旭
  • 依托单位:
生物素-亲和素介导超声造影剂对乳腺癌血管生成分子靶向显像的研究
  • 批准号:
    30670580
  • 项目类别:
    面上项目
  • 资助金额:
    26.0万元
  • 批准年份:
    2006
  • 负责人:
    李颖嘉
  • 依托单位:
超声微泡造影剂携靶基因治疗及其声像图监控研究
  • 批准号:
    30430230
  • 项目类别:
    重点项目
  • 资助金额:
    130.0万元
  • 批准年份:
    2004
  • 负责人:
    王志刚
  • 依托单位: