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MRI-guided HIFU-mediated heating and lesion formation enhanced with phase-shift n

MRI 引导的 HIFU 介导的加热和病变形成通过相移增强

基本信息

批准号：
8100353
负责人：
Tyrone Porter
金额：
$ 19.12万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2013-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): MRI-guided HIFU-mediated heating and lesion formation enhanced with phase-shift nanoemulsions MRI-guided high intensity focused ultrasound (HIFU) has shown promise as a method for destroying solid tumors noninvasively through thermal mechanisms. While HIFU can destroy localized malignancies via the formation of lesions (i.e. coagulated tissue) with a high degree of spatial precision, it can take hours to treat an entire tumor. This has limited the efficiency of MRI-guided HIFU cancer therapy, and has hindered its acceptance clinically. It has been demonstrated that acoustic cavitation (i.e. acoustically-driven bubbles) can increase the efficiency of MRI-guided HIFU mediated heating and lesion formation in tissue. We have developed a phase-shift nanoemulsion (PSNE) to serve as nuclei for acoustic cavitation. By accumulating preferentially in solid tumors, the PSNE localize bubble nuclei to the diseased tissue. The PSNE can be vaporized acoustically, and the resultant bubbles can be used to accelerate ultrasound-mediated heating, thus reducing the time required for treatment of bulk tumors. We have designed a series of studies to evaluate the effectiveness of the strategy for localizing bubble-enhanced heating and producing predictable lesions in solid tumors. Finally, MR imaging and thermometry can be used to monitor bubble-enhanced HIFU-mediated heating, ensure that the required thermal dose for thermal ablation is delivered, and predict the lesion volume and location. PUBLIC HEALTH RELEVANCE: Cancer is the second leading cause of death in the United States. The research outlined in this proposal will develop technology and protocols for localized treatment of solid tumors using focused ultrasound with negligible adverse side effects. Ultimately, this technology has the potential to reduce the time and number of treatments required for tumor regression, thus reducing costs and improving cancer patient care.

描述（由申请人提供）：通过相移纳米乳剂增强 MRI 引导的 HIFU 介导的加热和病变形成 MRI 引导的高强度聚焦超声（HIFU）已显示出作为一种通过热机制非侵入性破坏实体瘤的方法的前景。虽然 HIFU 可以通过形成高度空间精度的病灶（即凝固组织）来破坏局部恶性肿瘤，但治疗整个肿瘤可能需要数小时。这限制了MRI引导的HIFU癌症治疗的效率，并阻碍了其在临床上的接受。已经证明，声空化（即声驱动的气泡）可以提高 MRI 引导的 HIFU 介导的组织加热和病变形成的效率。我们开发了一种相移纳米乳液（PSNE）作为声空化的核。通过优先在实体瘤中积累，PSNE 将气泡核定位于患病组织。 PSNE 可以声波汽化，产生的气泡可用于加速超声介导的加热，从而减少治疗大块肿瘤所需的时间。我们设计了一系列研究来评估局部气泡增强加热和在实体瘤中产生可预测病变的策略的有效性。最后，MR 成像和测温可用于监测气泡增强 HIFU 介导的加热，确保提供热消融所需的热剂量，并预测病变体积和位置。公共卫生相关性：癌症是美国第二大死因。该提案中概述的研究将开发使用聚焦超声局部治疗实体瘤的技术和方案，且副作用可忽略不计。最终，这项技术有可能减少肿瘤消退所需的时间和治疗次数，从而降低成本并改善癌症患者的护理。