HHSN261201500003I; HHSN26100071; 400.021.0071.0001; NCI CBIIT; APPROPRIATED; EXPAND DATA COMMONS; 09/14/18-09/13/23

HHSN261201500003I；

• 批准号: 10282463
• 负责人: DWAYNE FORQUER
• 金额: $ 1050万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-14 至 2023-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10282463
• 关键词: Authorization documentation; Data; Data Commons; Data Science; Data Storage and Retrieval; Elements; Environment; Genomic Data Commons; Image; Infrastructure; Malignant Neoplasms; Modeling; Ontology; Orphan; Resources; Secure; Semantics; Validation; Vision; Vocabulary; analytical tool; anticancer research; cancer genomics; data ecosystem; data framework; data integration; data modeling; data sharing; data submission; data tools; design; experience; genomic data; genomics cloud; knowledge base; multimodal data; repository; tool; working group

The Beau Biden Cancer Moonshot Blue Ribbon Panel Enhanced Data Sharing Working Group recommended the creation of a data science infrastructure necessary to connect repositories, analytical tools, and knowledge bases to allow data to be aggregated, queried, analyzed, and visualized in unique and powerful ways within and across data types. In line with this vision, the NCI has created components - the Genomic Data Commons (GDC) and the Cancer Genomics Cloud Pilots - that define some of the core elements and capabilities necessary for realizing an NCI Cancer Research Data Commons (CRDC), which itself is an important component of a National Cancer Data Ecosystem. Building upon the experience gained in developing the GDC and the Cloud Pilots and evaluating the gaps present in those initiatives relative to a CRDC, NCI is defining a reusable, expandable framework for the Data Commons. This Commons Framework will include and support: (1) secure user authentication and authorization; (2) data submission, including validation against data models and vocabularies; (3) domain-specific, extensible data models; (4) principles for data and tool discoverability; (5) an API and container environment for tools and pipelines; (6) and user workspaces for storing data, tools, and results.

Beau Biden Cancer Moonshot Blue Ribbon Panel增强数据共享工作组建议创建必要的数据科学基础设施，以连接存储库，分析工具和知识库，从而允许以独特而强大的方式在数据类型内和跨数据类型聚合，查询，分析和可视化数据。根据这一愿景，NCI创建了基因组数据共享（GDC）和癌症基因组学云试点（Cancer Genomics Cloud Pilots），定义了实现NCI癌症研究数据共享（CRDC）所需的一些核心要素和功能，CRDC本身就是国家癌症数据生态系统的重要组成部分。基于在开发GDC和云试点以及评估这些计划相对于CRDC存在的差距方面所获得的经验，NCI正在为数据共享定义一个可重用，可扩展的框架。这个共享资源框架将包括并支持：（1）安全的用户身份验证和授权;（2）数据提交，包括根据数据模型和词汇表进行验证;（3）特定于领域的可扩展数据模型;（4）数据和工具可重用性原则;（5）用于工具和管道的API和容器环境;（6）用于存储数据、工具和结果的用户界面。