HHSN261201500003I; HHSN26100071; 400.021.0071.0001; NCI CBIIT; APPROPRIATED; EXPAND DATA COMMONS; 09/14/18-09/13/23

Beau Biden癌症登月计划蓝带小组增强型数据共享工作组建议创建必要的数据科学基础设施，以连接存储库、分析工具和知识库，从而允许数据以独特而强大的方式在数据类型内部和跨数据类型进行汇总、查询、分析和可视化。根据这一愿景，NCI创建了基因组数据共享（GDC）和癌症基因组云试点（Cancer Genomics Cloud Pilots），这些组件定义了实现NCI癌症研究数据共享（CRDC）所需的一些核心元素和功能，CRDC本身就是国家癌症数据生态系统的重要组成部分。基于在开发GDC和Cloud Pilots中获得的经验，以及评估这些计划相对于CRDC中存在的差距，NCI正在为数据共享定义一个可重用、可扩展的框架。此共享框架将包括并支持：(1)安全用户身份验证和授权；(2)数据提交，包括对数据模型和词汇表的验证；(3)领域特定的、可扩展的数据模型；(4)数据和工具可发现性原则；(5)工具和管道的API和容器环境；(6)和用户工作区，用于存储数据、工具和结果。

The Beau Biden Cancer Moonshot Blue Ribbon Panel Enhanced Data Sharing Working Group recommended the creation of a data science infrastructure necessary to connect repositories, analytical tools, and knowledge bases to allow data to be aggregated, queried, analyzed, and visualized in unique and powerful ways within and across data types. In line with this vision, the NCI has created components - the Genomic Data Commons (GDC) and the Cancer Genomics Cloud Pilots - that define some of the core elements and capabilities necessary for realizing an NCI Cancer Research Data Commons (CRDC), which itself is an important component of a National Cancer Data Ecosystem. Building upon the experience gained in developing the GDC and the Cloud Pilots and evaluating the gaps present in those initiatives relative to a CRDC, NCI is defining a reusable, expandable framework for the Data Commons. This Commons Framework will include and support: (1) secure user authentication and authorization; (2) data submission, including validation against data models and vocabularies; (3) domain-specific, extensible data models; (4) principles for data and tool discoverability; (5) an API and container environment for tools and pipelines; (6) and user workspaces for storing data, tools, and results.