A holistic approach in patient management and epidemic surveillance through convergence of diagnostic technologies, capacity building and stakeholder engagement (HoliCare)

通过诊断技术、能力建设和利益相关者参与的融合，采用整体方法进行患者管理和流行病监测（HoliCare）

• 批准号: 10044479
• 金额: $ 97.52万
• 依托单位: TEESSIDE UNIVERSITY
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10044479
• 关键词: holistic; approach; patient; management; epidemic

Research on Poverty-Related Diseases (PRDs) in sub-Saharan Africa suffers from major technological and non-technological challenges that prevent high quality healthcare to reach many areas. Not only their performance, but also the affordability, manufacturability, suitability for Low- and Middle-Income Countries (LMICs) and deployment of the (few) available diagnostics are main barriers to ensure good quality of healthcare in sub-Saharan Africa. The HoliCare project aims to tackle such challenges from a holistic perspective, by bridging the gap between technological excellence, available infrastructures, capacity, and local uptake of new technologies. We have chosen to work with lower respiratory infections as a blueprint for our new approach due to their huge clinical and socioeconomic impact, and relevance to the SARS-CoV-2 pandemic. Technology-wise, we propose a 2-tiered, digitally interfaced diagnostic approach that will start in the field using multiplexed lateral flow tests for rapid screening and triage, followed by a referral to a hospital (when needed) and a follow-up detailed diagnosis using a POC-Instrument performing simultaneous nucleic acid amplification (LAMP) for pathogen identification and immunoassays for host biomarker quantitation. Digital and manufacturing infrastructures will encompass these technology innovations to ensure future local product development. Quality controlled biobanks will be developed for executing reliable clinical studies. Training and human capital investment will be achieved by focussed and high-level training activities. Adoption and implementation activities will pave the way for the proposed diagnostic solutions to be successfully deployed, fitting the purpose of the local populations. Our developments will be scalable, adaptable and transferrable to other diseases and national (eco) systems, aiming to contribute to the improvement of healthcare delivery in sub-Saharan Africa.

撒哈拉以南非洲地区与艾滋病相关的疾病（PRD）研究面临重大的技术和非技术挑战，这些挑战阻碍了高质量的医疗保健服务进入许多地区。不仅其性能，而且其可负担性、可制造性、对低收入和中等收入国家的适用性以及可用诊断方法的部署（少数）都是确保撒哈拉以南非洲地区医疗保健质量的主要障碍。HoliCare项目旨在从整体的角度应对这些挑战，弥合技术卓越、现有基础设施、能力和当地对新技术的吸收之间的差距。我们选择下呼吸道感染作为我们新方法的蓝图，因为它们具有巨大的临床和社会经济影响，并与SARS-CoV-2大流行相关。在技术方面，我们提出了一种2层数字接口诊断方法，该方法将在现场使用多重侧向流测试进行快速筛查和分诊，然后转诊到医院（需要时），并使用POC仪器进行同步核酸扩增（LAMP）进行病原体鉴定和免疫测定进行宿主生物标志物定量的后续详细诊断。数字和制造基础设施将涵盖这些技术创新，以确保未来的本地产品开发。将开发质量受控的生物库，用于执行可靠的临床研究。培训和人力资本投资将通过重点突出的高水平培训活动来实现。通过和实施活动将为成功部署拟议的诊断解决方案铺平道路，符合当地居民的目的。我们的发展将是可扩展的，适应性强，可转移到其他疾病和国家（生态）系统，旨在促进改善撒哈拉以南非洲的医疗保健服务。