The Administrative Core of Prefrontal Cortex, Cognition, and Speech Symptoms in Parkinson’s disease (PRECIS-PD)

摘要 帕金森病患者前额叶皮质、认知和言语症状的管理核心 (PRECIS-PD)将促进新的合作项目，这些项目将促进我们对 前额叶皮质在帕金森病认知和语言功能障碍中的作用由Dr。 Nandakumar Narayanan(项目主任/首席调查员)，这个核心将提供领导， 监督和项目管理，这将构成拟议的探索性工作的组织基础 GRANT，以及未来NINDS Udall Center P50的申请。行政核心将推动 跨项目的研究集成和协同效应，并培养我们研究人员之间的沟通 以及我们的内部和外部委员会。爱荷华大学将为一个专门的和 有经验的研究管理员管理拟议的探索性补助金。这些努力将是 得到伊利诺伊大学杰出研究机构的大力支持，包括 神经学、爱荷华州神经科学研究所(INI)以及临床和翻译科学研究所 (信息通信技术)。 行政核心将为PRECIS-PD提供重点、领导和愿景，促进开放和 有效的研究沟通，开发数据分析和数据共享的管道，并确保我们的 研究是稳健的、严谨的和可重复的。该管理核心将管理所有P20项目，以 收集创新的初步数据，以支持未来的P50应用。我们的重点将放在 围绕高质量的神经生理数据进行沟通和组织，并培养 变革发现的环境将对帕金森病患者的生活产生有意义的影响。

Abstract The Administrative Core of Prefrontal Cortex, Cognition, and Speech Symptoms in Parkinson’s disease (PRECIS-PD) will facilitate new collaborative projects that will advance our understanding of the prefrontal cortex (PFC) in cognitive and speech dysfunction in Parkinson’s disease (PD). Led by Dr. Nandakumar Narayanan (Program Director/Principal Investigator), this core will provide the leadership, oversight, and project management that will form the organizational basis for the proposed Exploratory Grant, as well as for a future NINDS Udall Center P50 application. The Administrative Core will promote research integration and synergies across projects and cultivate communication among our researchers and our internal and external committees. The University of Iowa will provide funding for a dedicated and experienced Research Administrator to manage the proposed Exploratory Grant. These efforts will be heavily buttressed by the outstanding research organizations at UI, including the Department of Neurology, the Iowa Neuroscience Institute (INI), and the Institute for Clinical and Translational Sciences (ICTS). The Administrative Core will provide focus, leadership, and vision for PRECIS-PD, foster open and effective research communication, develop pipelines for data analysis and data sharing, and ensure our research is robust, rigorous, and reproducible. This Administrative Core will manage all P20 projects to collect innovative preliminary data towards supporting a future P50 application. Our focus will be on communication and organization around high-quality neurophysiological data, and on cultivating an environment of transformational discovery that will inspire meaningful impact in the lives of PD patients.