The Administrative Core of Prefrontal Cortex, Cognition, and Speech Symptoms in Parkinson’s disease (PRECIS-PD)

摘要 帕金森病患者前额叶皮层、认知和言语症状的管理核心 （PRECIS-PD）将促进新的合作项目，这将促进我们对 前额叶皮层（PFC）在帕金森病（PD）认知和言语功能障碍中的作用。博士领导 Nandakumar Narayanan（项目主任/首席研究员），该核心将提供领导， 监督和项目管理，这将构成拟议的探索性项目的组织基础。 赠款，以及未来的NINDS尤德尔中心P50应用程序。行政核心将促进 研究整合和跨项目的协同作用，并培养我们的研究人员之间的沟通 以及我们的内部和外部委员会。爱荷华州大学将提供资金， 经验丰富的研究管理员来管理拟议的探索性补助金。这些努力将 在UI的优秀研究机构的大力支持下，包括 神经病学，爱荷华州神经科学研究所（INI）和临床和转化科学研究所 （ICTS）。 行政核心将为PRECIS-PD提供重点，领导和愿景，促进开放和 有效的研究沟通，开发数据分析和数据共享渠道，并确保我们的 研究是稳健、严谨和可重复的。该行政核心将管理所有P20项目， 收集创新的初步数据，以支持未来的P50应用。我们的重点将放在 围绕高质量的神经生理学数据进行交流和组织，并培养一个 变革性发现的环境，将激发对PD患者生活的有意义的影响。

Abstract The Administrative Core of Prefrontal Cortex, Cognition, and Speech Symptoms in Parkinson’s disease (PRECIS-PD) will facilitate new collaborative projects that will advance our understanding of the prefrontal cortex (PFC) in cognitive and speech dysfunction in Parkinson’s disease (PD). Led by Dr. Nandakumar Narayanan (Program Director/Principal Investigator), this core will provide the leadership, oversight, and project management that will form the organizational basis for the proposed Exploratory Grant, as well as for a future NINDS Udall Center P50 application. The Administrative Core will promote research integration and synergies across projects and cultivate communication among our researchers and our internal and external committees. The University of Iowa will provide funding for a dedicated and experienced Research Administrator to manage the proposed Exploratory Grant. These efforts will be heavily buttressed by the outstanding research organizations at UI, including the Department of Neurology, the Iowa Neuroscience Institute (INI), and the Institute for Clinical and Translational Sciences (ICTS). The Administrative Core will provide focus, leadership, and vision for PRECIS-PD, foster open and effective research communication, develop pipelines for data analysis and data sharing, and ensure our research is robust, rigorous, and reproducible. This Administrative Core will manage all P20 projects to collect innovative preliminary data towards supporting a future P50 application. Our focus will be on communication and organization around high-quality neurophysiological data, and on cultivating an environment of transformational discovery that will inspire meaningful impact in the lives of PD patients.