Function of TCF-1 in antagonizing malignancy

人类的免疫系统天生就有能力杀死癌细胞。但突变和其他 异常会阻碍或中和它，使免疫系统不充分和无效。 目前正在进行大量投资来研究如何刺激免疫系统以 杀死癌细胞。然而，有证据表明，在某些情况下，增强免疫力 该系统实际上促进了癌细胞的生长。我们正在试图理解这种现象是如何 行得通。尤其是在涉及TCF-1基因突变的情况下- 当免疫系统受到刺激时，实际上会促进淋巴瘤的生长。我们希望学到 TCF-1基因如何调节免疫反应影响淋巴瘤的发生。

The human immune system is naturally capable of killing cancer cells. But mutations and other abnormalities handicap or neutralize it, making the immune system insufficient and ineffective. Currently there is a lot of investment being made to study how to stimulate the immune system to kill cancer cells. However, there is evidence that in certain circumstances boosting the immune system actually encourages cancer cell growth. We’re trying to understand how this phenomenon works. Particularly, under the circumstances when a TCF-1 gene mutation is involved — the immune system, when stimulated, actually promotes the growth of lymphoma. We expect to learn how TCF-1 gene regulates the immune responses to affect the lymphoma development.