Function of TCF-1 in antagonizing malignancy

人体免疫系统自然能够杀死癌细胞。但是突变和其他 异常会阻碍或抵消它，使免疫系统不足和无效。 目前有大量的投资正在研究如何刺激免疫系统， 杀死癌细胞。然而，有证据表明，在某些情况下， 系统实际上鼓励癌细胞生长。我们试图了解这种现象 工程.特别是，在涉及TCF-1基因突变的情况下， 免疫系统，当刺激，实际上促进淋巴瘤的生长。我们希望了解 TCF-1基因是如何调节免疫反应从而影响淋巴瘤的发展。

The human immune system is naturally capable of killing cancer cells. But mutations and other abnormalities handicap or neutralize it, making the immune system insufficient and ineffective. Currently there is a lot of investment being made to study how to stimulate the immune system to kill cancer cells. However, there is evidence that in certain circumstances boosting the immune system actually encourages cancer cell growth. We’re trying to understand how this phenomenon works. Particularly, under the circumstances when a TCF-1 gene mutation is involved — the immune system, when stimulated, actually promotes the growth of lymphoma. We expect to learn how TCF-1 gene regulates the immune responses to affect the lymphoma development.