Function of TCF-1 in antagonizing malignancy

TCF-1对抗恶性肿瘤的作用

• 批准号: 10435550
• 负责人: Zuoming Sun
• 金额: $ 26.4万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10435550
• 关键词: Acute; Adverse effects; Affect; Autoimmunity; B-Cell Antigen Receptor; CD3 Antigens; Cancer Cell Growth; Cells; Collaborations; Development; Environment; Experimental Autoimmune Encephalomyelitis; Frequencies; Gene Mutation; Generations; Genes; Growth; Health; Helper-Inducer T-Lymphocyte; Hematopoietic; Human; Immune; Immune checkpoint inhibitor; Immune response; Immune system; Immunity; Immunization; Immunotherapy; Induced Mutation; Interleukin-17; Investments; Laboratories; Lead; Learning; Light; Lymphoblastic lymphoma; Lymphoma; Lymphomagenesis; Malignant Neoplasms; Mediating; Meridians; Mus; Mutation; Nobel Prize; Play; Prevention; Proliferating; Relapse; Research; Role; Serum; Signal Transduction; T cell transcription factor 1; T-Cell Development; T-Cell Receptor; T-Lymphocyte; Testing; Therapeutic; Thymic Lymphoma; Thymocyte Development; Thymus Gland; Treatment Failure; Work; cancer cell; cancer immunotherapy; cytokine; effective therapy; gene network; high risk; in vivo; innovation; novel; prevent; response; therapy development; thymocyte; transcription factor; tumorigenesis

The human immune system is naturally capable of killing cancer cells. But mutations and other abnormalities handicap or neutralize it, making the immune system insufficient and ineffective. Currently there is a lot of investment being made to study how to stimulate the immune system to kill cancer cells. However, there is evidence that in certain circumstances boosting the immune system actually encourages cancer cell growth. We’re trying to understand how this phenomenon works. Particularly, under the circumstances when a TCF-1 gene mutation is involved — the immune system, when stimulated, actually promotes the growth of lymphoma. We expect to learn how TCF-1 gene regulates the immune responses to affect the lymphoma development.

人体免疫系统自然能够杀死癌细胞。但是突变和其他 异常会阻碍或抵消它，使免疫系统不足和无效。 目前有大量的投资正在研究如何刺激免疫系统， 杀死癌细胞。然而，有证据表明，在某些情况下， 系统实际上鼓励癌细胞生长。我们试图了解这种现象 工程.特别是，在涉及TCF-1基因突变的情况下， 免疫系统，当刺激，实际上促进淋巴瘤的生长。我们希望了解 TCF-1基因是如何调节免疫反应从而影响淋巴瘤的发展。