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Anticipating ethical challenges and disparities in the dissemination of novel neurotechnologies

预测新型神经技术传播中的伦理挑战和差异

基本信息

批准号：
10283140
负责人：
Winston Chiong
金额：
$ 44.85万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-10 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10283140
关键词：
Address Adoption Affect Attention Attitude BRAIN initiative Base of the Brain Brain Brain Diseases COVID-19 pandemic Caring Clinic Clinical Collaborations Communities Complex Consensus Consent Development Devices Ensure Epilepsy Ethics Ethnic Origin Ethnography FDA approved Face Funding Future Geography Goals Health Promotion Housing Implant Information Dissemination Institution Institutional Racism International Internet Intervention Interview Investments Justice Leadership Methods Mind Mission Neurology Neurosciences Participant Pathway interactions Patient Care Patients Population Privacy Psychiatry Public Health Race Recording of previous events Religion Reporting Research Research Methodology Research Personnel Risk Role Sampling Science Social Problems Social Sciences Socioeconomic Status Specialized Center Structure Surveys Techniques Technology Underserved Population United States National Institutes of Health Universities Victimization Work base community engaged research community engagement comparative compliance behavior disability family burden health equity improved individual patient innovation insight member neglect neural implant neuroethics neuropsychiatric disorder neuropsychiatry neuroregulation neurotechnology new technology novel novel strategies novel therapeutics prospective racial and ethnic recruit science and society side effect social socioeconomics tool

项目摘要

PROJECT SUMMARY/ABSTRACT A central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for brain diseases. However, improving care for neuropsychiatric illness will require not only discovering interventions, but also ensuring that research products meet patients’ needs and are accessible to underserved groups. While neuroethics to date has largely examined individualistic concerns (such as privacy, consent and identity), this application uses closed-loop neuromodulation as a circuit-based treatment paradigm for examining neuroethical challenges at a societal level such as equity/access and the democratization of research methods. To address challenging topics including socioeconomic, racial/ethnic, and geographic disparities will require special expertise in rigorous social science and in community engagement, to include perspectives missing in academic neuroethical discourse. Applying principles of community-engaged research, a Community Advisory Board will be recruited to meet quarterly with project leaders and advise on preliminary findings, research methods and the dissemination of results. Nationwide collaborations have been developed to facilitate research pursuing three specific aims: 1) Compare ethical concerns about novel neurotechnology among diverse groups; 2) Examine practice and patient factors in access to closed-loop neuromodulation in varied clinical settings; and 3) Investigate ethical and practical challenges in reducing barriers to closed-loop neuromodulation research. Aim 1 will address the views of prospective patients/users about neurotechnology in a nationally-representative sample with a focus on underserved groups. Aim 2 will examine the clinic setting via comparative ethnographic research in epilepsy centers using NeuroPace RNS treatment, which is currently the only FDA-approved and commercially available closed-loop brain implant, and therefore can be used to anticipate broader challenges in psychiatry and neurology with future applications of closed-loop approaches. Aim 3 will utilize a novel opportunity for studying ethical concerns in research through a new NIH-funded international collaboration to disseminate expertise and best practices in closed-loop neuromodulation. The approach is innovative, in the applicants’ view, addressing societal-level neuroethical concerns with advanced social scientific and community engagement methods not widely applied in neuroethics. The proposed research is significant because it addresses considerations of equity and democratization that are critical to future neurotechnology and neuroscience. Ultimately, this work will broaden the scope of normative issues addressed in neuroethics, such as distributive justice and tensions in broadening research. In neurotechnology, the work will contribute to fuller engagement with ethical challenges in the adoption of new techniques and the early integration of neuroethics in efforts to lower research barriers.

项目总结/文摘