Rapid detection of infectious viral particles by cluster induced exhaustive reaction
通过簇诱导穷举反应快速检测感染性病毒颗粒
基本信息
- 批准号:10282122
- 负责人:
- 金额:$ 19.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-02 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAddressAerosolsAffinityAirAmericanAntibodiesAntigensBindingBiological AssayBloodBreathingCOVID-19COVID-19 detectionCOVID-19 pandemicCessation of lifeCommunicable DiseasesCommunitiesCoronavirusCoughingDepositionDetectionDevicesDiagnosisDiagnosticEnsureEnvironmentEnzyme-Linked Immunosorbent AssayEpitopesEvaluationExhalationExhibitsGoalsGoldGovernmentHealthHorseradish PeroxidaseHospitalsHumanImmigrationImmunoglobulin GImmunoglobulin MIndividualInfectionLengthLifeLiftingLocationMeasuresMethodsNebulizerPaperPatientsPersonsPoliciesPolymerase Chain ReactionPopulationRapid diagnosticsReactionRecording of previous eventsResourcesSafetySamplingSensitivity and SpecificitySignal TransductionSiteSneezingSocietiesSpecificitySpeedSpottingsSurfaceSymptomsTannic AcidTechniquesTechnologyTestingTimeVariantViralVirionVirusVisualizationbaseclinical Diagnosiscostdesigndetection limitdiagnostic technologiesexhaustionfluinfluenzavirusinnovationinstrumentmultiplex detectionnanoparticlepandemic diseaseparticlepathogenrapid detectionrapid testreconstitutionrespiratoryrespiratory virusscreeningsensortooltransmission processwastingyoung adult
项目摘要
Summary
The COVID-19 pandemic has posed enormous challenges to health, economy, environment and immigration in
the US. Enhancement of diagnosis capacity together with restriction policies has been widely implemented to
contain the virus spreading. However, there are still over 200,000 deaths and half million hospitalized in the US
alone. The virus, Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), is highly contagious while
early infection particularly in young adults often exhibits no symptoms when they are actively transmitting viruses
in the community through speaking and breathing. These two transmission approaches normally emit much
lower number of virus particles in aerosols than coughing and sneezing, and thus are difficult to detect. Despite
many types of diagnostic tools available, current on-site diagnostic technologies do not have the sufficient
sensitivity and speed to detect low number of virus particles in aerosols emitted by infected people. The gold
standard method, polymerase chain reaction (PCR), and its variants are only ultrasensitive in the lab setting to
detect low copy number of viruses. Emitted aerosols are attractive target for clinical diagnosis because sampling
is not invasive, and the detection results directly determine whether a person is spreading viruses or not. To
address the above challenge, we will develop a rapid diagnostic technology based on cluster induced exhaustive
reaction (CIER) with the few virus sensitivity and disposable device with the cost of pennies, so that this kind of
paper device can be used frequently anywhere to identify an infectious individual immediately before he/she
further spreads SARS-CoV-2 to the community. CIER enables theoretically unlimited amplification of signal while
maintaining high specificity, and thus is highly applicable to detect SARS-CoV-2 particles where only the compact
cluster of antigens can trigger the CIER sensor. Two specific aims are proposed: (1) Construct CIER sensor by
assembling antibodies, spacer and HRP moieties, and optimize CIER’s design for detecting of SARS-CoV-2
virus particles with ultra-high sensitivity, and (2) Rapidly quantify SARS-CoV-2 virus particles in breath and on
surface for POC diagnosis, and distinguish influenza virus from SARS-CoV-2 by multiplexed detection. This
transformative diagnostic technology will possess ultrahigh sensitivity and specificity to detect SARS-CoV-2
viruses in exhaled air while in low cost and simple to use by any person. The use of CIER paper will not only
immediately identify virus spreading people, but also save huge waste of resources to contain pandemic by a
small percentage of contagious individuals.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jun Wang其他文献
Spiking Neural Systems with Weights
带权重的尖峰神经系统
- DOI:
- 发表时间:
- 期刊:
- 影响因子:2.9
- 作者:
Jun Wang;Hendrik Jan Hoogeboom;Gheorghe Paun;Linqiang Pan - 通讯作者:
Linqiang Pan
Jun Wang的其他文献
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- 批准号:
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Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals
开发针对病毒主要蛋白酶和宿主组织蛋白酶 L 的双重抑制剂作为 SARS-CoV-2 抗病毒药物
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CCL5/CCR5轴在抑郁症中的性别特异性作用及其治疗意义
- 批准号:
10364861 - 财政年份:2022
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Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals
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Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals
开发针对病毒主要蛋白酶和宿主组织蛋白酶 L 的双重抑制剂作为 SARS-CoV-2 抗病毒药物
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10693823 - 财政年份:2022
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$ 19.6万 - 项目类别:
Sex-specific role of CCL5/CCR5 axis in depression and its therapeutic implication
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- 资助金额:
$ 19.6万 - 项目类别:
Rapid detection of infectious viral particles by cluster induced exhaustive reaction
通过簇诱导穷举反应快速检测感染性病毒颗粒
- 批准号:
10443877 - 财政年份:2021
- 资助金额:
$ 19.6万 - 项目类别:
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