Biomarker phenotypes of air pollution and cancer risk in India

印度空气污染和癌症风险的生物标志物表型

• 批准号: 10286264
• 负责人: Rajesh Dikshit
• 金额: $ 30.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10286264
• 关键词: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; Aerodigestive Tract; Air; Air Pollutants; Air Pollution; Albumins; Aldehydes; Area; Aromatic Polycyclic Hydrocarbons; Biological Assay; Biological Availability; Biological Markers; Biological Monitoring; Cancer Center; Carcinogens; Case-Control Studies; Chemicals; Cohort Studies; Collaborations; Cotinine; Country; Data; Development; Devices; Epidemiology; Exposure to; Frequencies; Future; Goals; Head and Neck Cancer; High Prevalence; India; Individual; Intervention; Investigation; Knowledge; Laboratories; Laboratory Research; Life Style; Malignant Neoplasms; Malignant neoplasm of larynx; Malignant neoplasm of lung; Measurement; Measures; Metals; Minnesota; Occupational Exposure; Occupations; Oral; Outcome Study; Participant; Plasma; Policies; Population; Populations at Risk; Preventive measure; Questionnaires; Research; Risk; Risk Factors; Role; Sampling; Site; Smokeless Tobacco; Smoker; Smoking; Source; Subgroup; Testing; Tobacco; Tobacco use; Universities; Urine; adduct; air sampling; ambient air pollution; anticancer research; base; biomarker panel; cancer epidemiology; cancer prevention; cancer risk; carcinogenicity; case control; chemical carcinogen; cohort; demographics; design; dietary; disorder risk; expectation; experience; head and neck cancer patient; insight; malignant oropharynx neoplasm; metropolitan; non-smoker; non-smoking; novel; novel marker; oxidative DNA damage; phenotypic biomarker; pollutant; recruit; residence; smokeless tobacco use; smokeless tobacco user; smoking prevalence; specific biomarkers; tool; toxicant; uptake

ABSTRACT Chemical toxicants and carcinogens present in the polluted air are the likely causative agents in the associated cancers of aerodigestive tract in exposed individuals. Understanding the relationship between the level of exposure to these pollutants and the risk of cancer is key to identifying individuals or populations at risk and informing the development of preventive measures. The overarching goal of this study is to advance such understanding through a collaborative research between the Masonic Cancer Center, University of Minnesota and Centre for Cancer Epidemiology (CCE) in Mumbai, India. We will employ a panel of established and novel air pollution-related biomarkers to test our overall hypothesis that the uptake of air pollution-related chemical carcinogens is associated with the risk for LC and HNC in Indian nonsmokers. In Aims 1 and 2, we will conduct case-control studies to assess the association of air pollution-related biomarkers in plasma with LC and HNC, respectively, in Indian nonsmokers. To achieve the goals of these Aims, we will use available biological samples and questionnaire data from the corresponding epidemiological cohorts conducted by the CCE. We will develop capacity for biomarker measurements at CCE by transferring the U.S. team's expertise in this area. In Aim 3, we will recruit healthy nonsmokers with various levels of usual exposures to air pollution, based on their occupation or lifestyle. We will compare a panel of biomarkers of exposure and effect across the groups and correlate to pollutant levels collected through personal air sampling devices worn by a subset of participants. We will use specially designed air samplers to characterize the chemical profile of various air pollution scenarios. This aim will aid in the interpretation of biomarker data generated in Aims 1 and 2, and will inform future biomarker-based studies of air pollution in India. An important outcome of this study is the development of capacity for future biomarker research of cancer risk in India using CCE cohorts. Such research can be further expanded to other population subgroups (e.g., smokers or occupationally exposed individuals) and additional environmental and dietary exposures in India.

摘要 污染空气中存在的化学毒物和致癌物质可能是相关疾病的致病因子。 暴露者的呼吸消化道癌症。理解水平之间的关系 暴露于这些污染物和癌症的风险是识别处于风险中的个人或人群的关键， 为制定预防措施提供信息。这项研究的总体目标是促进这种 通过明尼苏达大学共济会癌症中心和 和印度孟买的癌症流行病学中心（CCE）。我们将聘请一个专家小组， 与空气污染相关的生物标志物来检验我们的总体假设，即与空气污染相关的化学物质的摄入 致癌物与印度非吸烟者的LC和HNC风险相关。在目标1和2中，我们将 病例对照研究，以评估血浆中空气污染相关生物标志物与LC和HNC的相关性， 在不吸烟的印度人中。为了实现这些目标，我们将利用现有的生物技术， 样本和调查问卷数据来自CCE进行的相应流行病学队列。我们 将通过转移美国团队在这方面的专业知识， 区在目标3中，我们将招募健康的非吸烟者，他们通常暴露于不同水平的空气污染， 职业或生活方式。我们将比较一组生物标志物的暴露和影响， 小组和相关的污染物水平收集通过个人空气采样装置佩戴的一个子集， 参与者我们将使用特别设计的空气采样器来表征各种空气的化学成分 污染情景。这一目标将有助于解释目标1和2中生成的生物标志物数据， 为印度未来基于生物标志物的空气污染研究提供信息。这项研究的一个重要成果是， 发展印度未来使用CCE队列进行癌症风险生物标志物研究的能力。等 研究可以进一步扩展到其他人口亚组（例如，吸烟者或职业暴露者 个人）以及印度的其他环境和饮食暴露。