Biomarker phenotypes of air pollution and cancer risk in India
印度空气污染和癌症风险的生物标志物表型
基本信息
- 批准号:10286264
- 负责人:
- 金额:$ 30.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-23 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolAerodigestive TractAirAir PollutantsAir PollutionAlbuminsAldehydesAreaAromatic Polycyclic HydrocarbonsBiological AssayBiological AvailabilityBiological MarkersBiological MonitoringCancer CenterCarcinogensCase-Control StudiesChemicalsCohort StudiesCollaborationsCotinineCountryDataDevelopmentDevicesEpidemiologyExposure toFrequenciesFutureGoalsHead and Neck CancerHigh PrevalenceIndiaIndividualInterventionInvestigationKnowledgeLaboratoriesLaboratory ResearchLife StyleMalignant NeoplasmsMalignant neoplasm of larynxMalignant neoplasm of lungMeasurementMeasuresMetalsMinnesotaOccupational ExposureOccupationsOralOutcome StudyParticipantPlasmaPoliciesPopulationPopulations at RiskPreventive measureQuestionnairesResearchRiskRisk FactorsRoleSamplingSiteSmokeless TobaccoSmokerSmokingSourceSubgroupTestingTobaccoTobacco useUniversitiesUrineadductair samplingambient air pollutionanticancer researchbasebiomarker panelcancer epidemiologycancer preventioncancer riskcarcinogenicitycase controlchemical carcinogencohortdemographicsdesigndietarydisorder riskexpectationexperiencehead and neck cancer patientinsightmalignant oropharynx neoplasmmetropolitannon-smokernon-smokingnovelnovel markeroxidative DNA damagephenotypic biomarkerpollutantrecruitresidencesmokeless tobacco usesmokeless tobacco usersmoking prevalencespecific biomarkerstooltoxicantuptake
项目摘要
ABSTRACT
Chemical toxicants and carcinogens present in the polluted air are the likely causative agents in the associated
cancers of aerodigestive tract in exposed individuals. Understanding the relationship between the level of
exposure to these pollutants and the risk of cancer is key to identifying individuals or populations at risk and
informing the development of preventive measures. The overarching goal of this study is to advance such
understanding through a collaborative research between the Masonic Cancer Center, University of Minnesota
and Centre for Cancer Epidemiology (CCE) in Mumbai, India. We will employ a panel of established and novel
air pollution-related biomarkers to test our overall hypothesis that the uptake of air pollution-related chemical
carcinogens is associated with the risk for LC and HNC in Indian nonsmokers. In Aims 1 and 2, we will conduct
case-control studies to assess the association of air pollution-related biomarkers in plasma with LC and HNC,
respectively, in Indian nonsmokers. To achieve the goals of these Aims, we will use available biological
samples and questionnaire data from the corresponding epidemiological cohorts conducted by the CCE. We
will develop capacity for biomarker measurements at CCE by transferring the U.S. team's expertise in this
area. In Aim 3, we will recruit healthy nonsmokers with various levels of usual exposures to air pollution, based
on their occupation or lifestyle. We will compare a panel of biomarkers of exposure and effect across the
groups and correlate to pollutant levels collected through personal air sampling devices worn by a subset of
participants. We will use specially designed air samplers to characterize the chemical profile of various air
pollution scenarios. This aim will aid in the interpretation of biomarker data generated in Aims 1 and 2, and will
inform future biomarker-based studies of air pollution in India. An important outcome of this study is the
development of capacity for future biomarker research of cancer risk in India using CCE cohorts. Such
research can be further expanded to other population subgroups (e.g., smokers or occupationally exposed
individuals) and additional environmental and dietary exposures in India.
摘要
污染空气中存在的化学毒物和致癌物质可能是相关疾病的致病因子。
暴露者的呼吸消化道癌症。理解水平之间的关系
暴露于这些污染物和癌症的风险是识别处于风险中的个人或人群的关键,
为制定预防措施提供信息。这项研究的总体目标是促进这种
通过明尼苏达大学共济会癌症中心和
和印度孟买的癌症流行病学中心(CCE)。我们将聘请一个专家小组,
与空气污染相关的生物标志物来检验我们的总体假设,即与空气污染相关的化学物质的摄入
致癌物与印度非吸烟者的LC和HNC风险相关。在目标1和2中,我们将
病例对照研究,以评估血浆中空气污染相关生物标志物与LC和HNC的相关性,
在不吸烟的印度人中。为了实现这些目标,我们将利用现有的生物技术,
样本和调查问卷数据来自CCE进行的相应流行病学队列。我们
将通过转移美国团队在这方面的专业知识,
区在目标3中,我们将招募健康的非吸烟者,他们通常暴露于不同水平的空气污染,
职业或生活方式。我们将比较一组生物标志物的暴露和影响,
小组和相关的污染物水平收集通过个人空气采样装置佩戴的一个子集,
参与者我们将使用特别设计的空气采样器来表征各种空气的化学成分
污染情景。这一目标将有助于解释目标1和2中生成的生物标志物数据,
为印度未来基于生物标志物的空气污染研究提供信息。这项研究的一个重要成果是,
发展印度未来使用CCE队列进行癌症风险生物标志物研究的能力。等
研究可以进一步扩展到其他人口亚组(例如,吸烟者或职业暴露者
个人)以及印度的其他环境和饮食暴露。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rajesh Dikshit其他文献
Rajesh Dikshit的其他文献
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{{ truncateString('Rajesh Dikshit', 18)}}的其他基金
Biomarker phenotypes of air pollution and cancer risk in India
印度空气污染和癌症风险的生物标志物表型
- 批准号:
10493190 - 财政年份:2021
- 资助金额:
$ 30.32万 - 项目类别:
Biomarker phenotypes of air pollution and cancer risk in India
印度空气污染和癌症风险的生物标志物表型
- 批准号:
10665050 - 财政年份:2021
- 资助金额:
$ 30.32万 - 项目类别:
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