Biomarker phenotypes of air pollution and cancer risk in India

印度空气污染和癌症风险的生物标志物表型

• 批准号: 10286264
• 负责人: Rajesh Dikshit
• 金额: $ 30.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10286264
• 关键词: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; Aerodigestive Tract; Air; Air Pollutants; Air Pollution; Albumins; Aldehydes; Area; Aromatic Polycyclic Hydrocarbons; Biological Assay; Biological Availability; Biological Markers; Biological Monitoring; Cancer Center; Carcinogens; Case-Control Studies; Chemicals; Cohort Studies; Collaborations; Cotinine; Country; Data; Development; Devices; Epidemiology; Exposure to; Frequencies; Future; Goals; Head and Neck Cancer; High Prevalence; India; Individual; Intervention; Investigation; Knowledge; Laboratories; Laboratory Research; Life Style; Malignant Neoplasms; Malignant neoplasm of larynx; Malignant neoplasm of lung; Measurement; Measures; Metals; Minnesota; Occupational Exposure; Occupations; Oral; Outcome Study; Participant; Plasma; Policies; Population; Populations at Risk; Preventive measure; Questionnaires; Research; Risk; Risk Factors; Role; Sampling; Site; Smokeless Tobacco; Smoker; Smoking; Source; Subgroup; Testing; Tobacco; Tobacco use; Universities; Urine; adduct; air sampling; ambient air pollution; anticancer research; base; biomarker panel; cancer epidemiology; cancer prevention; cancer risk; carcinogenicity; case control; chemical carcinogen; cohort; demographics; design; dietary; disorder risk; expectation; experience; head and neck cancer patient; insight; malignant oropharynx neoplasm; metropolitan; non-smoker; non-smoking; novel; novel marker; oxidative DNA damage; phenotypic biomarker; pollutant; recruit; residence; smokeless tobacco use; smokeless tobacco user; smoking prevalence; specific biomarkers; tool; toxicant; uptake

ABSTRACT Chemical toxicants and carcinogens present in the polluted air are the likely causative agents in the associated cancers of aerodigestive tract in exposed individuals. Understanding the relationship between the level of exposure to these pollutants and the risk of cancer is key to identifying individuals or populations at risk and informing the development of preventive measures. The overarching goal of this study is to advance such understanding through a collaborative research between the Masonic Cancer Center, University of Minnesota and Centre for Cancer Epidemiology (CCE) in Mumbai, India. We will employ a panel of established and novel air pollution-related biomarkers to test our overall hypothesis that the uptake of air pollution-related chemical carcinogens is associated with the risk for LC and HNC in Indian nonsmokers. In Aims 1 and 2, we will conduct case-control studies to assess the association of air pollution-related biomarkers in plasma with LC and HNC, respectively, in Indian nonsmokers. To achieve the goals of these Aims, we will use available biological samples and questionnaire data from the corresponding epidemiological cohorts conducted by the CCE. We will develop capacity for biomarker measurements at CCE by transferring the U.S. team's expertise in this area. In Aim 3, we will recruit healthy nonsmokers with various levels of usual exposures to air pollution, based on their occupation or lifestyle. We will compare a panel of biomarkers of exposure and effect across the groups and correlate to pollutant levels collected through personal air sampling devices worn by a subset of participants. We will use specially designed air samplers to characterize the chemical profile of various air pollution scenarios. This aim will aid in the interpretation of biomarker data generated in Aims 1 and 2, and will inform future biomarker-based studies of air pollution in India. An important outcome of this study is the development of capacity for future biomarker research of cancer risk in India using CCE cohorts. Such research can be further expanded to other population subgroups (e.g., smokers or occupationally exposed individuals) and additional environmental and dietary exposures in India.

摘要 污染空气中存在的化学毒物和致癌物质可能是导致 暴露于空气中的人患上消化道癌症。理解不同层次之间的关系 接触这些污染物和患癌症的风险是识别处于危险和 告知预防措施的发展情况。这项研究的总体目标是推进这样的 通过明尼苏达大学共济会癌症中心的合作研究了解 和印度孟买的癌症流行病学中心。我们将聘请一组老牌和新奇的专家 空气污染相关生物标志物来测试我们的总体假设，即空气污染相关化学物质的摄取 在印度非吸烟者中，致癌物质与LC和HNC的风险有关。在目标1和目标2中，我们将进行 评估血浆中与空气污染相关的生物标志物与LC和HNC之间关系的病例对照研究 分别在印度不吸烟者中。为了实现这些目标，我们将利用现有的生物 来自CCE进行的相应流行病学队列的样本和问卷数据。我们 将通过转让美国团队在这方面的专业知识来发展CCE的生物标记物测量能力 区域。在目标3中，我们将招募健康的非吸烟者，他们通常接触不同程度的空气污染，基于 关于他们的职业或生活方式。我们将比较一组暴露和影响的生物标志物 并与通过个人空气采样设备收集的污染物水平相关联，这些设备由 参与者。我们将使用特别设计的空气采样器来表征各种空气的化学特征。 污染场景。这一目标将有助于解释目标1和目标2中产生的生物标记物数据，并将 告知未来基于生物标记物的印度空气污染研究。这项研究的一个重要成果是 利用CCE队列发展未来印度癌症风险生物标记物研究的能力。是这样的 研究可以进一步扩大到其他人口亚群(例如，吸烟者或职业接触者 在印度)以及额外的环境和饮食暴露。