Physiologically relevant modelling of the aerodigestive tract as a delivery and screening platform for drugs and bioactives

呼吸消化道的生理相关模型作为药物和生物活性物质的输送和筛选平台

• 批准号: BB/R019657/1
• 负责人: Jeff Pearson
• 金额: $ 70.25万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR019657%2F1
• 关键词: Physiologically; relevant; modelling; aerodigestive; tract

We have previously developed and made commericaly available a model of the upper digestive tract. This project will expand our modelling capability throughout the aerodigestive tract, specifically to include a lung airway model, and develop the first integrated model of the large intestine including the microbiome, mucus layer and large intestinal epithelia. In vitro systems with improved predictability allow the pharmaceutical industry to make data driven decisions early in their development pipeline, and the commercial applications for these systems are widespread and supported by the letters attached. We envisage that the first applications of these systems would be for colon and lung specific drug delivery studies, pre- and pro- biotics research, faecal transplantation studies, reflux, and host-microbiome studies.These systems will provide platforms for modelling organ specific drug delivery, disease states and interactions between these systems.

我们以前已经开发并提供了一个上消化道模型。该项目将扩大我们在整个呼吸消化道的建模能力，特别是包括肺气道模型，并开发包括微生物组，粘液层和大肠上皮细胞在内的第一个大肠综合模型。具有改进的可预测性的体外系统允许制药行业在其开发管道的早期做出数据驱动的决策，并且这些系统的商业应用是广泛的，并得到所附信件的支持。我们设想这些系统的第一个应用将是结肠和肺特异性药物递送研究、益生菌和益生菌研究、粪便移植研究、反流和宿主微生物组研究。这些系统将为模拟器官特异性药物递送、疾病状态和这些系统之间的相互作用提供平台。

项目成果

The rheological properties of an alginate satiety formulation in a physiologically relevant human model gut system

生理相关人体模型肠道系统中海藻酸盐饱腹感配方的流变特性

• DOI: 10.21037/aoe-20-89
• 发表时间: 2022
• 期刊: Annals of Esophagus
• 作者: Wilcox M

A Pilot Pre and Post 4 Week Intervention Evaluating the Effect of a Proprietary, Powdered, Plant Based Food on Micronutrient Status, Dietary Intake, and Markers of Health in a Healthy Adult Population.

• DOI: 10.3389/fnut.2022.945622
• 发表时间: 2022
• 期刊: FRONTIERS IN NUTRITION
• 影响因子: 5
• 作者: Wilcox, Matthew D.;Chater, Peter I.;Stanforth, Kyle J.;Williams, Rebecca;Brownlee, Iain A.;Pearson, Jeffrey P.
• 通讯作者: Pearson, Jeffrey P.

Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection.

• DOI: 10.1038/s41522-018-0057-2
• 发表时间: 2018
• 期刊: NPJ biofilms and microbiomes
• 影响因子: 9.2
• 作者: Bakshani CR;Morales-Garcia AL;Althaus M;Wilcox MD;Pearson JP;Bythell JC;Burgess JG
• 通讯作者: Burgess JG

The effect of seaweed enriched bread on carbohydrate digestion and the release of glucose from food.

• DOI: 10.1016/j.jff.2021.104747
• 发表时间: 2021-12
• 期刊: Journal of functional foods
• 影响因子: 5.6
• 作者: Wilcox MD;Cherry P;Chater PI;Yang X;Zulali M;Okello EJ;Seal CJ;Pearson JP
• 通讯作者: Pearson JP

In vitro modelling of the mucosa of the oesophagus and upper digestive tract: narrative review

食管和上消化道粘膜的体外建模：叙述回顾

• DOI: 10.21037/aoe-20-90
• 发表时间: 2022
• 期刊: Annals of Esophagus
• 作者: Stanforth K