Biomarker phenotypes of air pollution and cancer risk in India

印度空气污染和癌症风险的生物标志物表型

• 批准号: 10665050
• 负责人: Rajesh Dikshit
• 金额: $ 30.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665050
• 关键词: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; Aerodigestive Tract; Air Pollutants; Air Pollution; Albumins; Aldehydes; Area; Aromatic Polycyclic Hydrocarbons; Biological; Biological Assay; Biological Markers; Biological Monitoring; Cancer Center; Carcinogens; Case/Control Studies; Chemicals; Cohort Studies; Collaborations; Cotinine; Country; Data; Development; Devices; Epidemiology; Exposure to; Frequencies; Future; Goals; Head and Neck Cancer; High Prevalence; India; Individual; Indoor Air Pollution; Intervention; Investigation; Knowledge; Laboratories; Laboratory Research; Life Style; Malignant Neoplasms; Malignant neoplasm of larynx; Malignant neoplasm of lung; Measurement; Measures; Metals; Minnesota; Occupational Exposure; Occupations; Oral; Outcome Study; Participant; Plasma; Policies; Population; Populations at Risk; Preventive measure; Questionnaires; Research; Risk; Risk Factors; Role; Sampling; Site; Smokeless Tobacco; Smoker; Smoking; Source; Subgroup; Testing; Tobacco; Tobacco use; Universities; University of Minnesota Cancer Center; Urine; adduct; air sampler; air sampling; ambient air pollution; anticancer research; biomarker panel; cancer epidemiology; cancer prevention; cancer risk; carcinogenicity; case control; chemical carcinogen; cohort; demographics; design; dietary; disorder risk; expectation; experience; head and neck cancer patient; insight; malignant oropharynx neoplasm; metropolitan; non-smoker; non-smoking; novel; novel marker; oxidative DNA damage; phenotypic biomarker; pollutant; recruit; residence; smokeless tobacco use; smokeless tobacco user; smoking prevalence; specific biomarkers; tool; toxicant; uptake

ABSTRACT Chemical toxicants and carcinogens present in the polluted air are the likely causative agents in the associated cancers of aerodigestive tract in exposed individuals. Understanding the relationship between the level of exposure to these pollutants and the risk of cancer is key to identifying individuals or populations at risk and informing the development of preventive measures. The overarching goal of this study is to advance such understanding through a collaborative research between the Masonic Cancer Center, University of Minnesota and Centre for Cancer Epidemiology (CCE) in Mumbai, India. We will employ a panel of established and novel air pollution-related biomarkers to test our overall hypothesis that the uptake of air pollution-related chemical carcinogens is associated with the risk for LC and HNC in Indian nonsmokers. In Aims 1 and 2, we will conduct case-control studies to assess the association of air pollution-related biomarkers in plasma with LC and HNC, respectively, in Indian nonsmokers. To achieve the goals of these Aims, we will use available biological samples and questionnaire data from the corresponding epidemiological cohorts conducted by the CCE. We will develop capacity for biomarker measurements at CCE by transferring the U.S. team's expertise in this area. In Aim 3, we will recruit healthy nonsmokers with various levels of usual exposures to air pollution, based on their occupation or lifestyle. We will compare a panel of biomarkers of exposure and effect across the groups and correlate to pollutant levels collected through personal air sampling devices worn by a subset of participants. We will use specially designed air samplers to characterize the chemical profile of various air pollution scenarios. This aim will aid in the interpretation of biomarker data generated in Aims 1 and 2, and will inform future biomarker-based studies of air pollution in India. An important outcome of this study is the development of capacity for future biomarker research of cancer risk in India using CCE cohorts. Such research can be further expanded to other population subgroups (e.g., smokers or occupationally exposed individuals) and additional environmental and dietary exposures in India.

摘要