Role of early motor experience in infants with Down syndrome

早期运动经验对唐氏综合症婴儿的作用

• 批准号: 10284690
• 负责人: Seyda Ozcaliskan
• 金额: $ 42.9万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-08 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10284690
• 关键词: Address; Age-Months; Area; Body Weight; Child; Child Development; Clinical Trials; Cognitive; Control Groups; Custom; Development; Down Syndrome; Early Intervention; Face; Family; Fingers; Future; Genetic Diseases; Gestures; Goals; Health; Home; Individual; Infant; Infant Development; Intellectual functioning disability; Intervention; Investigation; Knowledge; Language; Language Development; Life; Longevity; Modeling; Motor; Motor Skills; Parent-Child Relations; Parents; Performance; Population; Procedures; Production; Quality of life; Research; Role; Speech; Thumb structure; Toddler; Touch sensation; Toy; Walking; Work; base; clinical outcome measures; clinical trial readiness; cognitive development; cognitive function; design; early onset; effective intervention; effectiveness clinical trial; experience; grasp; improved; indexing; infancy; learning outcome; motor control; patient oriented; recruit; scaffold; skills; treadmill

PROJECT SUMMARY Down syndrome (DS) is the most common genetic condition and causes significant development delays and weaknesses in the motor, cognitive, and language domains. It is important to study these co-occurring developmental challenges and develop effective intervention strategies for positive learning outcomes in multiple domains simultaneously. It was found that motor development is closely associated with cognitive and language development in typically developing infants and advances in motor development have developmental cascade effects on other domains. However, this interrelation has not been studied in infants with DS. Our prior work has shown that gross motor experience through body-weight-supported treadmill stepping leads to an earlier onset of walking and improves subsequent locomotor ability in infants with DS. However, we do not yet know the extent to which this motor experience advances cognitive and language development in infants with DS. Research also suggests that grasping, a major fine motor skill emerging in infancy, provides the needed scaffolding for subsequent gesture and speech production. However, research on grasping and its potential effects on other domains in infants with DS remains scarce. The objectives of this proposal are to understand: the role of (a) specific gross motor experience and (b) specific fine motor experience on the motor, cognitive and language development of infants with DS. Our central hypothesis is that motor (both gross and fine) experience will help advance cognitive and language development in infants with DS. We will recruit 45 infants with DS from the greater Atlanta area and beyond. There will be three groups: (a) gross motor (GM) group (n=15), entering the study at about 10 months of age; (b) gross motor plus fine motor (GM+FM) group (n=15), entering the study at about 10 months; and (c) control group (n=15), entering the study at about 20 months. Aim 1: Determine the effects of gross motor experience on cognitive and language development in infants with DS, comparing the GM and control groups. Only the GM group will receive a home-based, parent-guided practice of treadmill stepping from 10 months of age (T1) until onset of walking. We hypothesize that the GM group will show higher Bayley scores and better gesture and word production at termination of the GM intervention (T3) and five months thereafter (T4) than the control group. Aim 2: Determine the effects of fine motor experience on cognitive and language development in infants with DS who receive the GM intervention, particularly in gesture and word production, comparing the GM and GM+FM groups. Only the GM+FM group will receive fine motor experience in practice of grasping using “sticky mittens” from 10 months of age for about five months. We hypothesize that the GM+FM group will show further improvements in motor, cognitive and language domains, particularly in gesture and word production, than the GM group at termination of the FM intervention (T2) and again at T3 and T4. Our study will gain an in-depth understanding of the cascading effects of motor experience on cognitive and language development and lay the groundwork for future clinical trials in infants with DS.

项目摘要 唐氏综合征（DS）是最常见的遗传疾病，会导致严重的发育迟缓， 运动、认知和语言领域的弱点。研究这些共同发生的 发展的挑战，并制定有效的干预战略，积极的学习成果，在多种 域同时。研究发现，运动发育与认知和语言密切相关 典型发育婴儿的发育和运动发育的进展具有发育级联 影响其他领域。然而，这种相互关系尚未在DS婴儿中进行研究。我们之前的工作 显示通过体重支撑的跑步机步进的粗大运动体验导致较早的发作 并改善DS婴儿随后的运动能力。然而，我们还不知道 这种运动体验促进了DS婴儿的认知和语言发育。研究还 表明，抓握，一个主要的精细运动技能出现在婴儿期，提供了所需的脚手架， 随后手势和语音产生。然而，关于抓握及其对其他人的潜在影响的研究， 在患有DS的婴儿中的结构域仍然很少。本建议的目的是了解：（a） 特定的粗大运动体验和（B）特定的精细运动体验，包括运动、认知和语言 患有DS的婴儿的发展。我们的中心假设是，运动（包括粗和细）的经验将有助于 促进DS婴儿的认知和语言发育。我们将招募45名患有DS的婴儿， 大亚特兰大地区和更远的地方。将有三组：（a）粗大运动（GM）组（n=15），进入 （B）粗大运动加精细运动（GM+FM）组（n=15），在大约10个月大时进入研究; 约10个月;和（c）对照组（n=15），在约20个月时进入研究。目标1：确定 粗大运动体验对DS婴儿认知和语言发育的影响，比较GM 与对照组只有通用汽车集团将收到一个家庭为基础，家长指导的做法跑步机步进 从10个月龄（T1）开始，直至开始行走。我们假设，通用汽车集团将显示更高的贝利 在GM干预结束时（T3）和5个月时， 此后（T4），比对照组。目的2：确定精细运动体验对认知和 接受GM干预的DS婴儿的语言发育，特别是手势和单词 生产，比较GM和GM+FM组。只有GM+FM组将获得精细运动体验 从10个月大开始使用“粘性手套”抓握约5个月。我们假设 GM+FM组将在运动、认知和语言领域显示出进一步的改善，特别是在 手势和文字的生产，比GM组在终止FM干预（T2），并再次在T3和 T4我们的研究将深入了解运动体验对认知和行为的级联效应， 语言发展，并为未来的临床试验在婴儿与DS奠定基础。