Role of early motor experience in infants with Down syndrome

项目概要 这是对家长奖的为期一年的行政补充，题为“早期运动经验对婴儿的作用” 患有唐氏综合症（DS）”。与正常情况相比，患有 DS 的婴儿表现出明显较低的体力活动 发展同行。此外，几乎一半患有 DS 的婴儿患有睡眠问题，例如 睡眠时间减少，觉醒次数增加。 DS 儿童睡眠质量差与行动迟缓有关 认知功能和语言里程碑的实现较弱。我们的父项目将检查效果 GM 和 GM FM 干预对 DS 婴儿运动、认知和语言发展的影响。然而， 父项目中未包括对身体活动和睡眠模式的评估。因此，有一个 非常需要向家长添加使用加速度计对身体活动和睡眠模式的评估 项目。此外，美国国立卫生研究院最近发起了“UNITE”倡议，旨在识别和解决内部结构性种族主义。 NIH 的工作人员以及 NIH 支持的更大的科学界。根据 NIH UNITE 倡议， NICHD 发起了 STRIVE 倡议，继续促进其各方面的多样性、公平性和包容性 研究和劳动力。因此，我们建议在父项目中添加额外的多样性组件。 该补充项目的目标是评估 GM、GM FM 和 GM 的体力活动和睡眠模式 控制组，并促进母项目和补充项目的多样性、公平性和包容性。目标 1： 评估 GM 和 GM FM 运动体验对婴儿身体活动和睡眠质量的影响 与DS。我们将使用可穿戴式加速度计（Actigraphy）来收集身体活动和睡眠的数据 在所有三组（GM、GM FM 和对照）中连续 7 天在时间点测量脚踝和手腕 T3（GM 干预结束时）和 T4（干预后五个月）。我们假设 GM 与对照组相比，GM FM 组将表现出更多的白天体力活动和更好的夜间睡眠模式 在时间点 T3 和 T4 进行分组。补充项目将产生重要的身体知识 活动和睡眠质量，加强对父母健康相关结果的综合评估 项目。目标 2：通过增加 EDI 来促进母项目的公平、多样性和包容性 (EDI) 参与者招募和学生指导。我们将使用 NIH UNITE 和 NICHD STRIVE 的框架 通过指导两名代表性不足的毕业生来实现研究团队的多元化 学生的研究培训和职业发展。辅导计划将包括但不限于： 关于 (a) 人类受试者招募和社区外展，(b) 数据收集、编码和分析的培训， (c) 每周与 PI 举行会议，讨论研究进展并解决问题和障碍，(d) 以会议演讲的形式传播研究结果，以及 (e) 手稿撰写和资助。

PROJECT SUMMARY This is a one-year administrative supplement to the parent award titled “Role of early motor experience in infants with Down syndrome (DS)”. Infants with DS show significant lower physical activity compared to their typically developing counterparts. Furthermore, almost half of infants with DS suffer from sleep problems such as decreased sleep time and increased wake bouts. Poor sleep quality in children with DS has been linked to slower and weaker attainment of cognitive function and language milestones. Our parent project will examine the effect of both GM and GM+FM intervention on motor, cognitive, and language development in infants with DS. However, assessment of physical activity and sleep pattern was not included in the parent project. Therefore, there is a significant need to add the assessment of physical activity and sleep pattern using accelerometry to the parent project. In addition, NIH recently launched the UNITE initiative to identify and address structural racism within the NIH workforce as well as the NIH-supported greater scientific community. In line with the NIH UNITE initiative, NICHD launched the STRIVE initiative to continue promoting diversity, equity, and inclusion in all aspects of its research and workforce. We therefore propose to add an additional diversity component to the parent project. The goal of this supplement project is to evaluate physical activity and sleep pattern among GM, GM+FM, and control groups, and promote diversity, equity, and inclusion in the parent and supplement projects. Aim 1: Evaluate the effect of both GM and GM+FM motor experiences on physical activity and sleep quality in infants with DS. We will use wearable accelerometers (Actigraphy) to collect the data of physical activity and sleep from the ankle and the wrist for seven consecutive days in all three groups (GM, GM+FM, and control) at time point T3 (at the conclusion of GM intervention) and T4 (five months post intervention). We hypothesize that both GM and GM+FM groups will show greater daytime physical activity and better nighttime sleep pattern than the control group at both time points T3 and T4. The supplement project will generate important knowledge of physical activity and sleep quality and enhance the comprehensive assessment of health-related outcomes in the parent project. Aim 2: Promote the equity, diversity, and inclusion (EDI) of the parent project by increasing EDI in participant recruitment and student mentoring. We will use the framework of the NIH UNITE and NICHD STRIVE initiatives to diversify the composition of our research team by mentoring two underrepresented graduate students for their research training and career development. The mentoring plan will include, but not limited to, the training on (a) human subject recruitment and community outreach, (b) data collection, coding, and analysis, (c) weekly meetings with the PIs to discuss research progress and address questions and obstacles, (d) disseminating findings in a form of conference presentations, and (e) manuscript writing and grantsmanship.