Role of early motor experience in infants with Down syndrome

项目总结 这是一项为期一年的家长奖的行政补充，题为“婴儿早期运动经验的作用” 患有唐氏综合症(DS)“。患有DS的婴儿与正常婴儿相比，体力活动显著减少 发展中同行。此外，几乎一半患有DS的婴儿患有睡眠问题，如 减少睡眠时间，增加清醒次数。患有DS的儿童睡眠质量差与睡眠迟缓有关 认知功能和语言里程碑的获得较弱。我们的父项目将检查效果 GM和GM FM干预对DS婴儿运动、认知和语言发育的影响。然而， 对体力活动和睡眠模式的评估不包括在父项目中。因此，有一个 非常需要将使用加速度计对体力活动和睡眠模式的评估添加到父母 项目。此外，国立卫生研究院最近发起了联合倡议，以查明和解决国内结构性种族主义问题 NIH的工作人员以及NIH-支持更大的科学界。根据美国国立卫生研究院的联合倡议， 日内瓦排雷中心发起了争取倡议，以继续促进多样性、公平和包容性在其所有方面 研究和劳动力。因此，我们提议在母项目中增加一个额外的多样性部分。 这个补充项目的目标是评估GM、GM FM和GM FM之间的身体活动和睡眠模式 控制群体，促进多样性、公平性和包容性，纳入母项目和补充项目。目标1： 评价GM和GM FM运动体验对婴儿体力活动和睡眠质量的影响 使用DS。我们将使用可穿戴式加速计(Actigraph)来收集来自 所有三组(GM组、GM FM组和对照组)在时间点连续七天的脚踝和手腕 T3(GM干预结束时)和T4(干预后5个月)。我们假设通用汽车和通用汽车 与对照组相比，GM FM组白天的体力活动更多，夜间的睡眠模式更好 在T3和T4两个时间点分组。补充项目将产生重要的物理知识 活动和睡眠质量，并加强对父母健康相关结果的全面评估 项目。目标2：通过增加父项目的公平、多样性和包容性(EDI) 参与者招募和学生辅导。我们将利用NIH联合和NICHD努力的框架 通过指导两名代表性不足的毕业生，使我们研究团队的组成多样化的举措 学生为他们的研究训练和职业发展。指导计划将包括但不限于， 关于以下方面的培训：(A)人类科目征聘和社区外联；(B)数据收集、编码和分析； (C)与私人投资机构每周举行会议，讨论研究进展情况并解决问题和障碍，(D) 以会议陈述的形式传播调查结果，以及(E)手稿写作和文凭。

PROJECT SUMMARY This is a one-year administrative supplement to the parent award titled “Role of early motor experience in infants with Down syndrome (DS)”. Infants with DS show significant lower physical activity compared to their typically developing counterparts. Furthermore, almost half of infants with DS suffer from sleep problems such as decreased sleep time and increased wake bouts. Poor sleep quality in children with DS has been linked to slower and weaker attainment of cognitive function and language milestones. Our parent project will examine the effect of both GM and GM+FM intervention on motor, cognitive, and language development in infants with DS. However, assessment of physical activity and sleep pattern was not included in the parent project. Therefore, there is a significant need to add the assessment of physical activity and sleep pattern using accelerometry to the parent project. In addition, NIH recently launched the UNITE initiative to identify and address structural racism within the NIH workforce as well as the NIH-supported greater scientific community. In line with the NIH UNITE initiative, NICHD launched the STRIVE initiative to continue promoting diversity, equity, and inclusion in all aspects of its research and workforce. We therefore propose to add an additional diversity component to the parent project. The goal of this supplement project is to evaluate physical activity and sleep pattern among GM, GM+FM, and control groups, and promote diversity, equity, and inclusion in the parent and supplement projects. Aim 1: Evaluate the effect of both GM and GM+FM motor experiences on physical activity and sleep quality in infants with DS. We will use wearable accelerometers (Actigraphy) to collect the data of physical activity and sleep from the ankle and the wrist for seven consecutive days in all three groups (GM, GM+FM, and control) at time point T3 (at the conclusion of GM intervention) and T4 (five months post intervention). We hypothesize that both GM and GM+FM groups will show greater daytime physical activity and better nighttime sleep pattern than the control group at both time points T3 and T4. The supplement project will generate important knowledge of physical activity and sleep quality and enhance the comprehensive assessment of health-related outcomes in the parent project. Aim 2: Promote the equity, diversity, and inclusion (EDI) of the parent project by increasing EDI in participant recruitment and student mentoring. We will use the framework of the NIH UNITE and NICHD STRIVE initiatives to diversify the composition of our research team by mentoring two underrepresented graduate students for their research training and career development. The mentoring plan will include, but not limited to, the training on (a) human subject recruitment and community outreach, (b) data collection, coding, and analysis, (c) weekly meetings with the PIs to discuss research progress and address questions and obstacles, (d) disseminating findings in a form of conference presentations, and (e) manuscript writing and grantsmanship.