The Injectrode - A Truly Injectable Electrode for Dorsal Root Ganglion Stimulation to Treat Pain

Injectrode——真正的可注射电极，用于刺激背根神经节来治疗疼痛

• 批准号: 10286333
• 负责人: Kip A Ludwig
• 金额: $ 31.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2023-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10286333
• 关键词: Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease related dementia; Amyloid beta-Protein; Anatomy; Animal Model; Animal Testing; Animals; Astrocytes; Automobile Driving; Autopsy; Award; Brain; Cerebrospinal Fluid; Cerebrovascular Circulation; Chronic; Clinical Research; Clinical Trials; Complex; Cranial Nerves; Data; Development; Disease; Electrodes; Elements; Energy Transfer; Failure; Family suidae; Future; Generations; Human; Impaired cognition; Impairment; Inflammatory; Injectable; Injections; Intercellular Fluid; Intervention; Intracranial Pressure; Liquid substance; Measures; Modeling; Movement; Neurobehavioral Manifestations; Neurodegenerative Disorders; Neurofibrillary Tangles; Operative Surgical Procedures; Opioid; Output; Pain; Parents; Patients; Pattern; Penetration; Permeability; Physiological; Polymers; Process; Production; Protocols documentation; Publishing; Pump; Risk; Rodent; Route; Safety; Solid; Spinal Ganglia; Structure of choroid plexus; Symptoms; Syringes; System; Technology; Testing; Tissues; Transcutaneous Electric Nerve Stimulation; Ultrasonography; Validation; abeta deposition; base; brain parenchyma; cerebral artery; cerebral hemodynamics; combat; cost efficient; experimental study; first-in-human; foot; hyperphosphorylated tau; implantation; improved; middle cerebral artery; minimally invasive; misfolded protein; novel; pressure; prevent; prophylactic; safety study; wasting

Project Summary/Abstract: Clinical trials targeting the reduction of amyloid-β and hyperphosphorylated tau load have been largely unsuccessful against neurodegenerative diseases including Alzheimer’s (AD) and AD-related dementias (ADRD). This may be due to the relatively late stage at which they are deployed, wherein cognitive symptoms are already manifest and the underlying inflammatory and degenerative processes are well underway. Conversely, prophylactic intervention aims to prevent or mitigate initiation of harmful, self-propagating disease processes before they become uncontrollable. For a treatment to be used prophylactically, ie before the presence of significant symptoms, it must be ‘trivially invasive’, simple to use, and inexpensive. This is critical for the expected benefits when deployed before symptoms to outweigh the potential risks. In this supplement, we propose a novel application of the minimally invasive InjectrodeTM technology outlined in the parent award to treat pain, to target brain waste clearance and cerebral hemodynamics through cranial nerve stimulation as a potential prophylactic strategy to combat AD. The Injectrode consists of a polymer matrix which is liquid in a syringe but quickly cures into a solid form when injected into the body. This technology offers many advantages over traditionally made electrodes amenable to prophylactic use including minimally invasive implantation (a simple injection). The successful completion of these aims would provide pilot data demonstrating the Injectrode concept can be utilized to improve the clearance of molecules within the brain, while identifying likely physiological components driving CSF/ISF interchange for future optimization.

项目概要/摘要： 针对减少淀粉样蛋白-β和过度磷酸化的tau负载的临床试验已经在很大程度上进行。 对神经退行性疾病，包括阿尔茨海默氏症（AD）和AD相关痴呆， （ADRD）.这可能是由于他们部署的相对较晚的阶段，其中认知症状 已经很明显，潜在的炎症和退化过程正在进行中。 相反，预防性干预旨在预防或减轻有害的、自我传播的疾病的发生 在它们变得无法控制之前。用于治疗的药物（在治疗前） 如果存在显著的症状，则它必须是“轻微侵入性的”，使用简单且便宜。这对于以下方面至关重要： 在出现症状前展开的预期受益超过潜在风险。 在本补充中，我们提出了微创InjectrodeTM技术的新应用 概述了在父母奖，以治疗疼痛，以针对脑废物清除和脑血流动力学，通过 颅神经刺激作为对抗AD的潜在预防策略。注射电极由聚合物组成， 基质，其在注射器中为液体，但当注射到体内时迅速固化成固体形式。这项技术 提供了许多优于传统制造的适于预防性使用的电极的优点， 侵入性植入（简单注射）。这些目标的成功实现将提供试点数据， 证明了注射电极概念可用于改善脑内分子的清除， 同时识别驱动CSF/ISF互换的可能的生理成分以用于将来的优化。

项目成果

Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications.

• DOI: 10.3389/fbioe.2022.793945
• 发表时间: 2022
• 期刊: Frontiers in bioengineering and biotechnology
• 影响因子: 5.7
• 作者: Nicksic PJ;Donnelly DT;Hesse M;Bedi S;Verma N;Seitz AJ;Shoffstall AJ;Ludwig KA;Dingle AM;Poore SO
• 通讯作者: Poore SO

Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode.

• DOI: 10.1109/ner49283.2021.9441420
• 发表时间: 2021-05
• 期刊: International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering
• 作者: Dalrymple AN;Ting JE;Bose R;Nieuwoudt S;Franke M;Ludwig KA;Shoffstall AJ;Fisher LE;Weber DJ
• 通讯作者: Weber DJ