Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications.
Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications.
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DOI：
10.3389/fbioe.2022.793945
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发表时间：
2022
影响因子：
5.7
通讯作者：
Poore SO
中科院分区：
文献类型：
--
作者：
Nicksic PJ;Donnelly DT;Hesse M;Bedi S;Verma N;Seitz AJ;Shoffstall AJ;Ludwig KA;Dingle AM;Poore SO
自1957年发现骨的压电特性以来，科学家们一直在应用外源性电刺激来治疗。尽管在过去的60年里做出了努力，但电子骨生长刺激器并没有在临床上普遍使用。其原因包括高成本和临床医生对骨生长刺激剂的疗效缺乏信心。本叙述性综述的目的是检查支持电刺激及其对骨特性影响的临床前文献，并阐明临床翻译中的差距，重点是器械规格和作用机制。在研究这些研究时，趋势变得明显。体外和小动物研究成功地诱导成骨与所有电刺激模式：直流电，脉冲电磁场，电容耦合。然而，大型动物研究在很大程度上是不成功的非侵入性方式。这可能是由于具有不同电阻率水平的组织平面的尺度和厚度的问题，在小动物模型中不存在。此外，由于刺激强度和刺激方案的单位不同以及器械规格报告不完整，因此难以从研究中得出结论。为了更好地理解大型和小型动物模型之间的脱节，作者建议增加这些研究的科学严谨性，并根据刺激方式报告一组新的最小参数。
Since the piezoelectric quality of bone was discovered in 1957, scientists have applied exogenous electrical stimulation for the purpose of healing. Despite the efforts made over the past 60 years, electronic bone growth stimulators are not in common clinical use. Reasons for this include high cost and lack of faith in the efficacy of bone growth stimulators on behalf of clinicians. The purpose of this narrative review is to examine the preclinical body of literature supporting electrical stimulation and its effect on bone properties and elucidate gaps in clinical translation with an emphasis on device specifications and mechanisms of action. When examining these studies, trends become apparent. In vitro and small animal studies are successful in inducing osteogenesis with all electrical stimulation modalities: direct current, pulsed electromagnetic field, and capacitive coupling. However, large animal studies are largely unsuccessful with the non-invasive modalities. This may be due to issues of scale and thickness of tissue planes with varying levels of resistivity, not present in small animal models. Additionally, it is difficult to draw conclusions from studies due to the varying units of stimulation strength and stimulation protocols and incomplete device specification reporting. To better understand the disconnect between the large and small animal model, the authors recommend increasing scientific rigor for these studies and reporting a novel minimum set of parameters depending on the stimulation modality.
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影响因子：
1.9
作者：
Escobar, Juan Felipe;Vaca-Gonzalez, Juan Jairo;Garzon-Alvarado, Diego Alexander
通讯作者：
Garzon-Alvarado, Diego Alexander
DOI：
10.1097/00002517-199407010-00005
发表时间：
1994-02-01
期刊：
JOURNAL OF SPINAL DISORDERS
影响因子：
--
作者：
GUIZZARDI, S;DISILVESTRE, M;SCANDROGLIO, R
通讯作者：
SCANDROGLIO, R
DOI：
10.1097/00003086-199603000-00036
发表时间：
1996-03-01
影响因子：
4.2
作者：
Brumback, R J
通讯作者：
Brumback, R J
DOI：
10.2147/dddt.s89669
发表时间：
2015
期刊：
Drug design, development and therapy
影响因子：
--
作者：
Atalay Y;Gunes N;Guner MD;Akpolat V;Celik MS;Guner R
通讯作者：
Guner R
影响因子：
2.8
作者：
BRIGHTON, CT;HUNT, RM
通讯作者：
HUNT, RM