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Project 2: Smokers

项目 2：吸烟者

基本信息

批准号：
10290162
负责人：
Chanita A. Hughes-Halbert
金额：
$ 15.87万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10290162
关键词：
Acute Address Adult Africa African American American Behavior Behavioral Belief Bioinformatics Biological Biological Markers Biological Process Biometry Center for Translational Science Activities Chronic Chronic stress Cigarette Collection Communities Counseling Data Dose Evidence based treatment Exposure to FDA approved Hydrocortisone Individual Intervention Laboratories Leadership Maintenance Malignant neoplasm of lung Measures Medicine Metabolism Modeling Morbidity - disease rate Neighborhoods Nicotine Nicotine Dependence Observational Study Outcome Pathway interactions Pattern Pharmacotherapy Physiological Population Prevention strategy Process Production Reaction Relapse Research Resource Sharing Risk Risk Factors Smoke Smoker Smoking Smoking Behavior Stress Structure Sympathetic Nervous System Tobacco Work acute stress base biological adaptation to stress cancer health disparity cancer risk cigarette craving cigarette smoke cigarette smoking community engagement hypothalamic-pituitary-adrenal axis insight lung cancer prevention male men mortality nicotine cessation nicotine exposure nicotine replacement nicotine use novel perceived stress physiologic stressor psychologic psychosocial psychosocial stressors racial difference racial disparity racial minority response smoking cessation smoking initiation social stressor success tobacco control translational study

项目摘要

PROJECT 2: PROJECT SUMMARY Physiological stress responses are among the multilevel determinants of cancer health disparities that need to be examined within the context of other SES, psychosocial, and structural factors. Project 2 will be the first to examine racial differences in HPA-axis functioning between African American/Black and white male smokers at increased risk for lung cancer morbidity and mortality by measuring acute cortisol responses to a laboratory stressor and evaluating racial disparities in daily cortisol patterns among these men in their neighborhoods and communities. Together with contextualized data on acute and chronic stress responses based on SES, psychosocial, and structural factors, Project 2 will generate novel empirical data that can be leveraged into precision strategies for lung cancer prevention through smoking cessation and other intervention approaches.

项目2：项目总结生理应激反应是癌症健康差异的多水平决定因素之一，需要在其他社会经济地位、心理社会和结构性因素的背景下进行审查。项目2将是第一个检查非裔美国人/黑人和白人男性吸烟者HPA轴功能的种族差异通过测量实验室的急性皮质醇反应来增加肺癌发病率和死亡率的风险应激源和评估这些社区和社区男性皮质醇日常模式的种族差异社区。与基于SES的急性和慢性应激反应的背景数据一起，心理社会和结构性因素，项目2将产生新的经验数据，可以利用这些数据通过戒烟和其他干预方法预防肺癌的精确策略。