Translational Research Center in Lung Cancer Disparities (TRACER)

肺癌差异转化研究中心 (TRACER)

• 批准号: 10493256
• 负责人: Chanita A. Hughes-Halbert
• 金额: $ 103.56万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493256
• 关键词: Address; African American population; Automobile Driving; Bioinformatics; Biological; Biological Markers; Biometry; Black American; Cancer Center; Cells; Center for Translational Science Activities; Chronic; City of Hope Comprehensive Cancer Center; Clinical; Collaborations; Collection; Communication; Communities; Community Participation; Complex; Data; Development; Diagnostic; Disease; Early Diagnosis; Exposure to; Fostering; Funding; Future; Genetic Markers; Geographic Locations; Goals; Health; Individual; Infrastructure; Intention; Intervention; Leadership; Link; Malignant Neoplasms; Malignant neoplasm of lung; Massey Cancer Center at the Virginia Commonwealth University; Medical; Minority Groups; Molecular Genetics; Morbidity - disease rate; National Cancer Institute; Neighborhoods; Outcome; Outcomes Research; Pathology; Pathway interactions; Prevention; Preventive; Psychosocial Stress; Research; Research Design; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Risk; Risk Factors; Science; Site; Smoking; Smoking Behavior; Societies; South Carolina; Stress; System; Therapeutic; Therapeutic Intervention; Training; Translating; Translational Research; Universities; Violence; Vision; base; cancer health disparity; career development; community engagement; education research; ethnic minority population; health equity; inter-institutional; interdisciplinary collaboration; lung cancer prevention; medically underserved population; mortality; next generation; novel; patient engagement; precision medicine; programs; racial and ethnic; racial discrimination; racial disparity; racial minority; research data dissemination; social; social capital; social determinants; socioeconomics; stressor; symposium; translational study

OVERALL: PROJECT SUMMARY Lung cancer continues to be one of the leading causes of morbidity and mortality among racial/ethnic minorities and individuals from other medically underserved groups. Racial minorities and individuals from other medically underserved groups have greater exposure to socioeconomic, financial, and other types of stressors (e.g., racial discrimination, structural stress because of low social capital and neighborhood violence) that can increase their risk for smoking and make it more difficult to quit. Chronic exposure to stress can trigger and disrupt biological pathways that are important to smoking behaviors and increase risk for lung cancer and other diseases. Therefore, the overarching goal and vision for the Translational Research Center in Lung Cancer Disparities (TRACER) is to address racial disparities in lung cancer morbidity and mortality by developing more precise strategies for lung cancer prevention and early detection. To accomplish this, TRACER will (1) discover cancer- driving biological mechanisms leading to racial disparities in lung cancer morbidity and mortality and analyze these mechanisms within the context of individual, social, and environmental determinants of health; (2) translate research findings into novel prevention, diagnostic, and therapeutic interventions; (3) develop an integrated inter- institutional partnership that promotes transdisciplinary research and leverages the distinct capabilities at each partner site to successfully obtain a P50 Cancer Disparities SPORE; and (4) promote bi-directional communications between AA/Black communities and investigators regarding research priorities, the development of culturally appropriate strategies for community engagement and participation in research, and the dissemination of education and research outcomes. The translational research and related training, patient and community engagement, and biospecimen collection activities in TRACER will focus explicitly on addressing racial disparities in lung cancer morbidity and mortality in order to fulfill a critical need to develop precision strategies for lung cancer prevention and early detection.

总体：项目摘要 肺癌仍然是少数种族/族裔发病和死亡的主要原因之一 以及其他医疗服务不足群体的个人。少数种族和来自其他医疗机构的个人 服务不足的群体更容易受到社会经济、金融和其他类型的压力源（例如，种族 歧视，结构性压力，因为低社会资本和邻里暴力），可以增加他们的 吸烟的风险，使戒烟更加困难。长期暴露在压力下会触发和破坏生物学 这些途径对吸烟行为很重要，并增加肺癌和其他疾病的风险。 因此，肺癌差异转化研究中心的总体目标和愿景 （TRACER）旨在通过开发更精确的 肺癌的预防和早期发现的策略。为了实现这一目标，TRACER将（1）发现癌症- 导致肺癌发病率和死亡率种族差异的生物学机制， 这些机制的背景下，个人，社会和环境的健康决定因素;（2）翻译 研究成果转化为新的预防、诊断和治疗干预措施;（3）制定一个综合性的国际 机构伙伴关系，促进跨学科的研究，并利用不同的能力，在每个 合作伙伴网站成功获得P50癌症差异孢子;和（4）促进双向 AA/黑人社区和研究人员之间关于研究优先事项的沟通， 为社区参与研究制定文化上适当的战略， 传播教育和研究成果。翻译研究和相关培训，患者 和社区参与，TRACER中的生物标本采集活动将明确侧重于解决 肺癌发病率和死亡率的种族差异，以满足发展精确性的关键需求 肺癌的预防和早期发现的策略。