Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment
为轻度认知障碍开发基于 ANS 的个性化认知训练
基本信息
- 批准号:10287421
- 负责人:
- 金额:$ 25.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-15 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgingAlzheimer&aposs disease pathologyAutonomic nervous systemBase of the BrainBehavior TherapyBloodBrainCardiacCardiovascular systemCategoriesClinical TrialsCognitiveDataData AnalysesDementiaDevelopmentDissociationDouble-Blind MethodEducational InterventionElderlyFrequenciesFunctional Magnetic Resonance ImagingFutureHealthImpaired cognitionIndividualInterventionInterviewLearningLinkMeasuresMethodsMonitorNerve DegenerationNeuronal PlasticityOrganismPerformancePhasePopulationQuestionnairesRandomizedRandomized Controlled TrialsSeriesSignal TransductionTask PerformancesTestingTimeTrainingTraining ProgramsWorkattentional controlbasecognitive changecognitive enhancementcognitive functioncognitive reservecognitive taskcognitive trainingcomputerizeddesignefficacy trialfeasibility testingflexibilityfollow-upheart rate variabilityimprovedindexinginformation processingintervention refinementmild cognitive impairmentneural circuitpersonalized approachpilot trialprecision medicinepreventprocessing speedprogramsprototyperelating to nervous systemresponsetheoriesusability
项目摘要
Abstract
Speed of processing training (SOPT), practicing to enhance the information processing efficiency while
performing various perceptual and cognitive tasks, is the widest examined type computerized cognitive training
among aging populations, including those with mild cognitive impairment (MCI). However, the efficacy of existing
SOPTs in maintaining or improving older adults' cognitive health greatly varies across individuals. Our
preliminary studies identified that the flexibility of autonomic nervous system (ANS) is associated with learning
and cognitive and neural gains in existing SOPT in older adults with MCI. Our premise is that adaptation capacity,
which is primarily reflected by ANS flexibility, is a key contributor to the neuroplasticity underlying broad and
sustained effects of cognitive interventions. In this proposed study, we will combine this ANS response profile
with the traditional learning index to develop a “personalization engine”, called pSOPT, for better
reflecting individual adaptation capacity, and to test pSOPT's feasibility (R21 phase) and preliminary
effect (R33 phase) in MCI. In R21 phase (intervention refinement, Stage Ia), we will establish a
“personalization engine” for the SOPT by taking advantage of unique information derived from ANS
assessment that links to learning and test the feasibility in MCI. Advanced time-series data analysis
methods (e.g., shapelet analysis) will be used to develop a prototype of pSOPT based on the previously identified
ANS shapelet. Compliance and usability of the pSOPT will be examined using interviews, questionnaires, and
recorded performance data using a single group design in older adults with MCI (n = 10). Specific aims include
(1) Use the identified ANS shapelet to develop a “personalization engine” that can modulate SOPT according to
real-time measures of ANS; (2) Examine the feasibility of administering the pSOPT. In R33 phase (pilot test,
Stage Ib), we will test the preliminary effects of the pSOPT in MCI. A pilot double-blinded randomized
controlled trial (RCT). An MCI group (N = 50) will be randomized into a 6-week pSOPT (n = 25), or attention
control (n = 25). Cardiac monitor-based ANS signals will be recorded throughout training sessions across groups.
Learning is indexed by performing accurately across a consecutive set of trials in training tasks. Cognitive battery
(measuring cognitive gains) and BOLD fMRI-based brain function (measuring neural gains) will be assessed at
baseline, post training (7-week), and short-term follow-up (3-month); neurodegeneration (T1MRI and blood-
based Alzheimer's pathology) assessed at baseline. Specific aims include (1) Compare changes of cognitive
and neural gains between groups; (2) Explore whether pSOPT will enhance ANS flexibility in supporting cognitive
gains against baseline neurodegeneration. This study is a prerequisite to efficiently launch an efficacy trial of
pSOPT in slowing dementia progress.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Feng Vankee Lin其他文献
Shared and unique functional connectivity correlates of geriatric depression subscales
- DOI:
10.1016/j.jagp.2022.12.150 - 发表时间:
2023-03-01 - 期刊:
- 影响因子:
- 作者:
Parnika Saxena;Adam Turnbull;Barbara Sommer;Daniel Kim;Feng Vankee Lin - 通讯作者:
Feng Vankee Lin
14. VALUES AND PRIORITIES OF OLDER ADULTS: CREATING COLLABORATIVE GOALS IN PSYCHIATRIC CARE
老年人的价值观和优先事项:在精神病护理中创建协作目标
- DOI:
10.1016/j.jagp.2025.04.017 - 发表时间:
2025-10-01 - 期刊:
- 影响因子:3.800
- 作者:
Ryan Pate;Christine Gould;Ira Yenko;Maryam Makowski;Oceanna Li;Vanessa Silva;Feng Vankee Lin;Dolores Gallagher-Thompson;Erin Cassidy-Eagle - 通讯作者:
Erin Cassidy-Eagle
13. OPTIMIZING THE DESIGN AND MEASUREMENT OF A MULTI-MODULE GROUP INTERVENTION TO IMPROVE WELL-BEING IN OLDER ADULTS
13. 优化多模块团体干预的设计与测量以改善老年人的幸福感
- DOI:
10.1016/j.jagp.2025.04.016 - 发表时间:
2025-10-01 - 期刊:
- 影响因子:3.800
- 作者:
Ira Yenko;Feng Vankee Lin;Christine Gould;Ryan Pate;Maryam Makowski;Oceanna Li;Vanessa Silva;Dolores Gallagher-Thompsom;Erin Cassidy-Eagle - 通讯作者:
Erin Cassidy-Eagle
The NEW Brain Aging Network – Opening a window on relationships between emotional well-being and the aging brain
- DOI:
10.1016/j.jagp.2022.12.311 - 发表时间:
2023-03-01 - 期刊:
- 影响因子:
- 作者:
Yeates Conwell;Feng Vankee Lin;Kimberly Van Orden;Quincy Samus - 通讯作者:
Quincy Samus
Feng Vankee Lin的其他文献
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{{ truncateString('Feng Vankee Lin', 18)}}的其他基金
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI_The ACT Trial COVID Admin Sup
有氧运动和认知训练相结合在 MCI_The ACT Trial COVID Admin Sup 中的功效和机制
- 批准号:
10747055 - 财政年份:2021
- 资助金额:
$ 25.06万 - 项目类别:
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI
有氧运动与认知训练相结合对 MCI 的疗效及机制
- 批准号:
10368684 - 财政年份:2021
- 资助金额:
$ 25.06万 - 项目类别:
Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment
为轻度认知障碍开发基于 ANS 的个性化认知训练
- 批准号:
10903126 - 财政年份:2021
- 资助金额:
$ 25.06万 - 项目类别:
Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment
为轻度认知障碍开发基于 ANS 的个性化认知训练
- 批准号:
10704837 - 财政年份:2021
- 资助金额:
$ 25.06万 - 项目类别:
Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment
为轻度认知障碍开发基于 ANS 的个性化认知训练
- 批准号:
10488295 - 财政年份:2021
- 资助金额:
$ 25.06万 - 项目类别:
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial)
有氧运动与认知训练相结合对 MCI 的功效和机制(ACT 试验)
- 批准号:
9447813 - 财政年份:2017
- 资助金额:
$ 25.06万 - 项目类别:
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial)
有氧运动与认知训练相结合对 MCI 的功效和机制(ACT 试验)
- 批准号:
9566811 - 财政年份:2017
- 资助金额:
$ 25.06万 - 项目类别:
Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults with Mild Cognitive Impairment
轻度认知障碍老年人基于视觉的认知处理速度的神经生理学方面
- 批准号:
8985335 - 财政年份:2015
- 资助金额:
$ 25.06万 - 项目类别:
Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults with Mild Cognitive Impairment
轻度认知障碍老年人基于视觉的认知处理速度的神经生理学方面
- 批准号:
9529687 - 财政年份:2015
- 资助金额:
$ 25.06万 - 项目类别:
Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults with Mild Cognitive Impairment
轻度认知障碍老年人基于视觉的认知处理速度的神经生理学方面
- 批准号:
9137710 - 财政年份:2015
- 资助金额:
$ 25.06万 - 项目类别:
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