Validating a Scalable, Open Science Framework for Collecting Laboratory-Grade Data Remotely in Specialized Populations

验证可扩展的开放科学框架,用于在特殊人群中远程收集实验室级数据

基本信息

  • 批准号:
    10289016
  • 负责人:
  • 金额:
    $ 23.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-01 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The limited repertoire of clinical outcome measures suitable for children with intellectual and developmental disabilities (IDD) is compromising the promise of clinical trials. Non-standardized laboratory techniques that capture “spectral” signals – such as psychophysiological assays – are increasingly recognized as promising methods for monitoring patient responses over time. However these tools require specialized equipment and personnel to administer and are not easily deployed via telehealth, biasing spectral studies toward patients who are able and willing to travel to clinics. Thus, there is a significant gap in available telehealth-based protocols for collecting laboratory-grade data remotely in IDD populations. The present study addresses this gap by developing a comprehensive training protocol for PANDABox (Parent Assisted Neurodevelopmental Assessment), an open-science, telehealth-based assessment protocol that PI Kelleher developed for remotely collecting high quality, integrated clinical, behavioral, and spectral assays from participants with IDD. Published findings indicate that PANDABox is highly feasible and acceptable to caregivers and generates high quality, integrated, “laboratory-grade” data at low cost. Already, PANDABox is being deployed in a variety of treatment and natural history studies across IDD populations and is being translated to Spanish to promote accessibility. The present study aims to enhance the scalability of PANDABox by accomplishing two specific aims. First, we will develop and validate an open-science training protocol and peer-to-peer reliability network to facilitate standardized, cross-laboratory implementation of the PANDABox protocol in IDD. This protocol will include both a virtual training hub for self-paced training, as well as a reliability network to facilitate cross-site calibration. Second, we will create user-friendly software program to support users to efficiently process the PANDABox attention assay, which has produced promising outcomes in clinical trials but requires computational expertise to analyze, limiting its scalability. Addressing these gaps would shift the status quo of clinical science in IDD by (1) providing a scalable, accessible protocol for collecting laboratory- grade data remotely in IDD populations and (2) producing standardized data outputs necessary for large scale, multi-site, collaborative science.
项目总结

项目成果

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Bridgette Lynne Kelleher其他文献

Bridgette Lynne Kelleher的其他文献

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{{ truncateString('Bridgette Lynne Kelleher', 18)}}的其他基金

Optimizing a Personalized Health Approach for Virtually Treating High-Risk Caregivers During COVID-19 and Beyond
优化个性化健康方法,以虚拟方式治疗 COVID-19 期间及之后的高风险护理人员
  • 批准号:
    10363469
  • 财政年份:
    2022
  • 资助金额:
    $ 23.05万
  • 项目类别:
Optimizing a Personalized Health Approach for Virtually Treating High-Risk Caregivers During COVID-19 and Beyond
优化个性化健康方法,以虚拟方式治疗 COVID-19 期间及之后的高风险护理人员
  • 批准号:
    10709470
  • 财政年份:
    2022
  • 资助金额:
    $ 23.05万
  • 项目类别:
Telehealth Assessment of Syndromic Autism Risk in Infants
婴儿综合症自闭症风险的远程医疗评估
  • 批准号:
    10181077
  • 财政年份:
    2017
  • 资助金额:
    $ 23.05万
  • 项目类别:
Telehealth Assessment of Syndromic Autism Risk in Infants
婴儿综合症自闭症风险的远程医疗评估
  • 批准号:
    9386578
  • 财政年份:
    2017
  • 资助金额:
    $ 23.05万
  • 项目类别:
Predicting Autism through Behavioral and Biomarkers of Attention in Infants
通过婴儿注意力的行为和生物标志物预测自闭症
  • 批准号:
    8575340
  • 财政年份:
    2011
  • 资助金额:
    $ 23.05万
  • 项目类别:
Predicting Autism through Behavioral and Biomarkers of Attention in Infants
通过婴儿注意力的行为和生物标志物预测自闭症
  • 批准号:
    8254642
  • 财政年份:
    2011
  • 资助金额:
    $ 23.05万
  • 项目类别:
Predicting Autism through Behavioral and Biomarkers of Attention in Infants
通过婴儿注意力的行为和生物标志物预测自闭症
  • 批准号:
    8391338
  • 财政年份:
    2011
  • 资助金额:
    $ 23.05万
  • 项目类别:

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