Developing an ultrafast fluorescence lifetime imaging ophthalmoscopy system for retinal imaging

开发用于视网膜成像的超快荧光寿命成像检眼镜系统

• 批准号: 10288094
• 负责人: Hsin-Chih Yeh
• 金额: $ 22.22万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10288094
• 关键词: Acute; Adopted; Affect; Age related macular degeneration; Algorithms; American; Animal Model; Biochemistry; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Computer software; Consumption; Data; Development; Diagnosis; Engineering; Eye; Eye diseases; Fluorescence; Frequencies; Functional Imaging; Fundus; Ganglion Cell Layer; Generations; Glaucoma; Goals; Gold; Hour; Hypoxia; Image; Impairment; Joints; Lead; Lighting; Measures; Metabolic; Methods; Microscopy; Modeling; Motivation; Nerve Degeneration; Ophthalmoscopy; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Photons; Photoreceptors; Physiologic pulse; Process; Publications; Reporting; Research; Retina; Retinal Diseases; Retinal Ganglion Cells; Role; Scanning; Scheme; Structure; System; Testing; Texas; Time; Universities; Vision; austin; base; biomarker identification; curve fitting; deep learning; deep learning algorithm; design; digital; experience; experimental study; fluorescence lifetime imaging; fluorophore; functional loss; in vivo; instrumentation; interest; microscopic imaging; next generation; reconstruction; retinal imaging; technology development; tool

PROJECT SUMMARY Age-related macular degeneration (AMD) is an eye disease that affects the central part of the retina and leads to impairments in central vision and sharp vision. According to the report from Centers for Disease Control and Prevention, AMD affects ~0.8% of people in US between 50 and 60, 1.5% between 60 and 70, ~4.8% between 70 and 80, and nearly 12% over 80 years old. Fluorescence lifetime imaging ophthalmoscopy (FLIO) has become an important tool in retinal diagnosis as it provides critical information about retina that the traditional fundus autofluorescence microscopy cannot provide. Whereas more demonstrations of FLIO in retina diagnosis at different stages of AMD have been shown in recent years, FLIO has not reached widespread use in clinics due to a number of fundamental limitations. Here we are developing an ultrafast fluorescence lifetime imaging ophthalmoscopy (uFLIO) system for rapid acquisition of retinal fundus autofluorescence and reconstruction of fluorescence lifetime images around the posterior pole of retina. The acquired autofluorescence lifetime information will help us understand the states of the endogenous fluorophores within the retina, and their roles and changes during the development of retinal diseases.

项目总结 老年性黄斑变性(AMD)是一种影响视网膜中央部分并导致 中心视力和敏锐视力受损。根据美国疾病控制和预防中心的报告 预防，AMD在美国50岁至60岁之间的人中影响约0.8%，60至70岁之间的人占1.5%，60岁至70岁的人中约4.8% 70岁和80岁，近12%的人超过80岁。荧光寿命成像眼底镜(Flio)已经成为 视网膜诊断的重要工具，因为它提供了关于视网膜的关键信息，而不是传统的眼底 自体荧光显微镜无法提供。鉴于Flio在视网膜诊断中的更多演示，请访问 近年来，AMD的不同阶段都被显示出来，Flio由于 一些根本性的限制。在这里我们正在开发一种超快荧光寿命成像 眼底镜(UFLIO)系统用于视网膜眼底自体荧光的快速获取和重建 视网膜后极周围的荧光寿命图像。获得的自体荧光寿命 信息将帮助我们了解视网膜内内源性荧光团的状态及其作用 以及视网膜疾病发展过程中的变化。