MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis

项目摘要 软骨下骨髓水肿性病变是核磁共振成像(MRI)的典型表现。 轴性脊柱炎(SpA)患者中的骶髂炎。骨髓的组织病理学等价物 轴性水疗中心的水肿症尚不清楚。基于对类风湿性关节炎的研究，我们假设骨骼 轴性SpA的骨髓水肿性病变表现为炎性浸润性病变。在这项先导性研究中，轴性心脏病患者 SpA和健康对照组将在MRI引导下进行骨髓活检，以确定其组织病理学。 在MRI上检测到骨髓水肿性病变，并确定这些细胞中存在的主要免疫细胞亚群 损伤。这些实验的结果将决定可行性，并指导更大规模的调查 探讨轴性温泉的发病机制。从分子水平认识SpA的发病机制 病变组织是制定治疗或预防这种疾病的策略的关键要求。

Project Summary Subchondral bone marrow edema lesions are a characteristic magnetic resonance imaging (MRI) finding of sacroiliitis in patients with axial spondyloarthritis (SpA). The histopathological equivalent of bone marrow edema in axial SpA is unknown. Based on studies in rheumatoid arthritis, we hypothesize that the bone marrow edema lesions in axial SpA represent inflammatory infiltrates. In this pilot study, patients with axial SpA and healthy controls will undergo MRI-guided bone marrow biopsy to determine the histopathology of bone marrow edema lesions detected on MRI and identify major immune cell subsets present in these lesions. The results from these experiments will determine feasibility and guide larger scale investigations into the pathogenesis of axial SpA in the future. Understanding SpA pathogenesis at the level of the diseased tissue is a key requirement for the development of strategies to cure or prevent this disease.