MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis

项目摘要 软骨下骨髓水肿病变是一个特征性的磁共振成像（MRI）发现 中轴型脊柱关节炎（SpA）患者骶髂关节炎的发生率。组织病理学上相当于骨髓 轴位SpA水肿未知。基于对类风湿性关节炎的研究，我们假设 轴位SpA的骨髓水肿病变代表炎性浸润。在这项初步研究中， SpA和健康对照将接受MRI引导的骨髓活检，以确定 在MRI上检测到骨髓水肿病变，并确定这些病变中存在的主要免疫细胞亚群。 病变这些实验的结果将确定可行性并指导更大规模的调查 轴性SpA的发病机制。在运动水平上理解SpA的发病机制 患病组织是开发治疗或预防该疾病的策略的关键要求。

Project Summary Subchondral bone marrow edema lesions are a characteristic magnetic resonance imaging (MRI) finding of sacroiliitis in patients with axial spondyloarthritis (SpA). The histopathological equivalent of bone marrow edema in axial SpA is unknown. Based on studies in rheumatoid arthritis, we hypothesize that the bone marrow edema lesions in axial SpA represent inflammatory infiltrates. In this pilot study, patients with axial SpA and healthy controls will undergo MRI-guided bone marrow biopsy to determine the histopathology of bone marrow edema lesions detected on MRI and identify major immune cell subsets present in these lesions. The results from these experiments will determine feasibility and guide larger scale investigations into the pathogenesis of axial SpA in the future. Understanding SpA pathogenesis at the level of the diseased tissue is a key requirement for the development of strategies to cure or prevent this disease.