Analyzing Disease Mechanisms in a Mouse Model of Spondyloarthritis
分析小鼠脊柱关节炎模型的疾病机制
基本信息
- 批准号:8825664
- 负责人:
- 金额:$ 7.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-12 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAllelesAnkylosing spondylitisAntibodiesAortitisApplications GrantsArthritisBiologicalBiologyCD3 AntigensCD8B1 geneCell Differentiation processCellsCellular ImmunologyClinicalColitisCollaborationsDataDevelopmentDiseaseDisease AssociationFactor AnalysisFutureGene ExpressionGene Expression ProfilingGenerationsGenesGenetic PolymorphismHLA-B27 AntigenHealthHistologyHistopathologyImmuneIn VitroInflammationInflammatoryInflammatory Bowel DiseasesInjection of therapeutic agentInterleukin-17InvestigationKnockout MiceLinkLiverLymphocyteLymphoid CellMHC Class I GenesMHC Class II GenesMediatingMediator of activation proteinMedicineModelingModificationMusNatureOsteogenesisOther GeneticsPaperPathogenesisPathway interactionsPhenotypePlant RootsPlasmidsProstaglandinsPsoriasisPsoriatic ArthritisReportingResearchRoleSignal TransductionSpondylarthritisSpondylitisSystemT-LymphocyteT-Lymphocyte SubsetsT-bet proteinTNF geneTailTestingTimeVeinsWorkarthropathiesbasebonecytokinedisease phenotypeexperiencegenetic risk factorgenome wide association studyhuman diseaseinflammatory markerinhibitor/antagonistinterleukin-22interleukin-23mature animalmeloxicammouse modelnano-stringoverexpressionreceptorresearch studyresponseskeletalskin disordersmall moleculetooltranscription factor
项目摘要
DESCRIPTION (provided by applicant): Spondyloarthritis encompasses a group of inflammatory disorders with shared genetic risk factors and overlapping clinical features. Data from genome-wide association studies point toward a central role for IL-23 in spondyloarthritis pathogenesis. A recent report (Sherlock et al. Nature Medicine 2012) described a spondyloarthritis-like illness in mice induced by IL-23 overexpression in adult animals and identified a CD4-CD8- double negative T cell subset that mediated disease development by secreting IL-17A and IL- 22 in response to IL-23. The proposed project is built on the premise that the IL-23 minicircle-induced spondyloarthritis model has enormous potential for elucidating the pathogenesis of spondyloarthritis. Specific Aim 1 analyzes factors controlling the development and function of the disease-mediating IL-23 receptor positive DN T cells. Using a panel of knockout mice we will test the hypothesis that these cells are MHC class I restricted αβTCR positive cells that may represent a link between HLA-B27 disease association, IL-23 and the development of spondyloarthritis. We will further explore the function of the transcription
factors T-bet and Ahr in these cells. In Specific Aim 2 we begin to interrogate the mechanism of osteoproliferation induced by the downstream mediator IL-22 and identify candidate pathways for future more detailed analysis.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joerg Ermann其他文献
Joerg Ermann的其他文献
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{{ truncateString('Joerg Ermann', 18)}}的其他基金
MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis
MRI引导下中轴型脊柱关节炎盆腔骨髓水肿病变活检
- 批准号:
10288006 - 财政年份:2021
- 资助金额:
$ 7.49万 - 项目类别:
MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis
MRI引导下中轴型脊柱关节炎盆腔骨髓水肿病变活检
- 批准号:
10455004 - 财政年份:2021
- 资助金额:
$ 7.49万 - 项目类别:
Analyzing Disease Mechanisms in a Mouse Model of Spondyloarthritis
分析小鼠脊柱关节炎模型的疾病机制
- 批准号:
8926851 - 财政年份:2014
- 资助金额:
$ 7.49万 - 项目类别:
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