Analyzing Disease Mechanisms in a Mouse Model of Spondyloarthritis

分析小鼠脊柱关节炎模型的疾病机制

基本信息

  • 批准号:
    8825664
  • 负责人:
  • 金额:
    $ 7.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-12 至 2017-08-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Spondyloarthritis encompasses a group of inflammatory disorders with shared genetic risk factors and overlapping clinical features. Data from genome-wide association studies point toward a central role for IL-23 in spondyloarthritis pathogenesis. A recent report (Sherlock et al. Nature Medicine 2012) described a spondyloarthritis-like illness in mice induced by IL-23 overexpression in adult animals and identified a CD4-CD8- double negative T cell subset that mediated disease development by secreting IL-17A and IL- 22 in response to IL-23. The proposed project is built on the premise that the IL-23 minicircle-induced spondyloarthritis model has enormous potential for elucidating the pathogenesis of spondyloarthritis. Specific Aim 1 analyzes factors controlling the development and function of the disease-mediating IL-23 receptor positive DN T cells. Using a panel of knockout mice we will test the hypothesis that these cells are MHC class I restricted αβTCR positive cells that may represent a link between HLA-B27 disease association, IL-23 and the development of spondyloarthritis. We will further explore the function of the transcription factors T-bet and Ahr in these cells. In Specific Aim 2 we begin to interrogate the mechanism of osteoproliferation induced by the downstream mediator IL-22 and identify candidate pathways for future more detailed analysis.


项目成果

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Joerg Ermann其他文献

Joerg Ermann的其他文献

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{{ truncateString('Joerg Ermann', 18)}}的其他基金

MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis
MRI引导下中轴型脊柱关节炎盆腔骨髓水肿病变活检
  • 批准号:
    10288006
  • 财政年份:
    2021
  • 资助金额:
    $ 7.49万
  • 项目类别:
MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis
MRI引导下中轴型脊柱关节炎盆腔骨髓水肿病变活检
  • 批准号:
    10455004
  • 财政年份:
    2021
  • 资助金额:
    $ 7.49万
  • 项目类别:
Analyzing Disease Mechanisms in a Mouse Model of Spondyloarthritis
分析小鼠脊柱关节炎模型的疾病机制
  • 批准号:
    8926851
  • 财政年份:
    2014
  • 资助金额:
    $ 7.49万
  • 项目类别:

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