AURA-ALZ: Connecting Audio and Radio Sensing Systems to Improve Care at Home for Persons with Early Alzheimer's Disease Or Related Dementias And Their Caregivers

AURA-ALZ：连接音频和无线电传感系统以改善对患有癌症患者的居家护理 早期阿尔茨海默病或相关痴呆症及其照顾者 摘要 作为对NOT-AG-20-034的回应，建议的针对阿尔茨海默氏症的补充剂将开发连接音频 和无线电传感系统改善对早期阿尔茨海默病或相关患者的家庭护理 痴呆症(ADRD)及其照顾者。本附录中提出的研究与亲本R01一致 研究(R01LM013329)。ADRD患者及其照顾者经常面临各种复杂的挑战 并经历巨大的护理负担。技术辅助护理干预的一种常见做法是引导 通过基于Web和移动电话的培训、至关重要的健康监测、症状 报告，并提供反馈和建议。这些干预计划，虽然已经被证明是 有效，有三大缺点。首先，护理团队的一名成员(患者或家属)必须 主动测量患者数据并将其输入系统，这是容易出错的、主观的，有时 被遗忘了。其次，基于网络或移动设备的交互可能会很麻烦，要求也很高。简单的任务，如 输入数据、评估运行状况或获取和响应警报需要键入和点击 一系列的电子表格。第三，系统和照顾者之间的互动，特别是当 系统需要提醒或确认智能手机/网站上的干预、简单通知和消息 往往是无效的，而且没有人注意到。改进以技术为基础的护理干预措施，更好地为人们提供服务 与ADRD及其照顾者一起，拟议的研究将采用以用户为中心的方法来适应和扩展 我们在正在进行的R01中一直在开发的AURA系统。研究的目的是：1)增加 AURA子系统的健壮性；2)吸引利益相关者(患有早期ADRD的人、护理人员、临床医生) 确定ADRD护理和护理的需求，以帮助为早期ADRD患者联合生产AURA-ALZ 3)确定AURA-ALZ的可用性、可接受性和可行性。 早期ADRD和照顾者二人之家使用混合方法。我们目前的R01旨在开发一种技术- 辅助AURA系统在膀胱癌术后患者中的应用 照顾者。AURA使用WiFi信号被动监控患者在家中的特定活动，定制自然 基于患者状态的语音助手的语言响应，并自动将数据输入到 减轻癌症照顾者负担的系统。AURA与护理团队在自然中进行沟通 用于提醒和确认收集的信息的语言，直观、免提且更少 要求很高。在AURA的基础上，AURA-ALZ将具有类似但增强的功能，以解决独特的护理 ADRD患者和照顾者的需求。这项研究阐述了NLM的使命：使生物医学 研究，支持医疗保健和公共卫生，促进健康行为。

AURA-ALZ: Connecting Audio and Radio Sensing Systems to Improve Care at Home for Persons with Early Alzheimer's Disease Or Related Dementias And Their Caregivers ABSTRACT In response to NOT-AG-20-034, the proposed Alzheimer’s-focused supplement will develop Connecting Audio And Radio Sensing Systems To Improve Care At Home for persons with early Alzheimer's disease or related dementias (ADRD) and their caregivers. The research proposed in this supplement aligns with the parent R01 study (R01LM013329). Persons with ADRD and their caregivers routinely confront various complex challenges and experience huge care burden. A common practice in technology-assisted care intervention is to guide patients and family caregivers through web and mobile phone-based training, health-vital monitoring, symptom reporting, and providing feedback and advice. These intervention programs, while have been shown to be effective, have three major demerits. First, a member of the care team (the patient or a family member) has to actively measure and enter patient data into the system, which is error-prone, subjective, and sometimes, forgotten. Second, web or mobile-based interactions can be cumbersome and demanding. Simple tasks like entering data, assessing health status, or getting and responding to an alert require typing and clicking through a series of electronic forms. Third, interactions between the system and the caregiver, especially when the system needs to remind or confirm an intervention, simple notifications and messages on a smartphone/website is often ineffective and unnoticed. To improve technology-based care interventions and to better serve persons with ADRD and their caregivers, the proposed study will adopt a user-centered approach to adapt and extend the AURA system that we have been developing in our ongoing R01. The research aims are: 1) Increase the robustness of the AURA subsystems; 2) Engage stakeholders (persons with early ADRD, caregivers, clinicians) to identify the needs of ADRD care and caregiving to help co-produce AURA-ALZ for persons with early ADRD and their caregivers; 3) Determine the usability, acceptability, and feasibility of AURA-ALZ in 10 persons with early ADRD and caregiver dyads' homes using mixed methods. Our current R01 aims to develop a technology- assisted AURA system for patients who are post-surgical treatment for bladder cancer and their caregivers. AURA passively monitors specific activities of a patient at home using WiFi signals, tailors natural language responses of voice assistants based on the patient's state, and automates entering data into the system to reduce the burden on the caregivers of cancer. AURA communicates with the care team in natural languages for reminders and confirmation of collected information, which is intuitive, handsfree, and less demanding. Building upon AURA, AURA-ALZ will have similar but enhanced features to address the unique care needs of persons with ADRD and caregivers. This study addresses the NLM’s mission of enabling biomedical research, supporting health care and public health, and promoting healthy behavior.