The Washington University Center for Diabetes Translation Research

项目摘要/摘要--概览 这是华盛顿大学糖尿病翻译中心的续展申请 研究(WU-CDTR)。该中心以我们的战略愿景为指导，在战略愿景中，健康公平镜头是 变革性糖尿病研究基金会转化为行动和影响。这一股权驱动的愿景 告知我们的中心使命是跨学科团队科学的纽带，推动 下一代糖尿病翻译研究。我们的目标是推进严谨、科学的证据基础，以 宣传对高危人群有效干预措施的传播、实施和可持续性 糖尿病的差异。WU-CDTR是一个杰出的调查人员网络的智力家园 研究糖尿病不平等的根本原因，了解健康和社会决定因素 围绕五个主题领域组织：生物行为发现；生活和工作条件；卫生保健 环境；卫生信息和技术环境；以及社区、政策和系统研究。这个 研究基地由来自内部的87名调查人员(66名正式成员和21名准成员)组成 华盛顿大学，以及21所不同的大学，其成员通过我们的地区和国家 资源核心(哥伦比亚密苏里大学健康管理和信息学系； 和宾夕法尼亚州德雷克塞尔大学黑人健康委员会)。我们的研究基础是 由既有糖尿病研究人员(69%)和新糖尿病研究人员(31%)以及代表不足的人定义 少数群体(38%)；成员与多部门伙伴网络合作(N=73) 包括医疗保健和非医疗保健组织。从2016年到现在，吴-CDTR调查人员 直接费用总额为2.432亿美元，年度直接费用为6680万美元。这包括86电流 持续的中心支持的赠款产生了1.733亿美元的总直接成本和4070万美元的年度 直接成本；WU-CDTR正式成员的65%有NIH资金，总赠款支持的80%来自联邦 消息来源。WU-CDTR由五个新的翻译研究核心组成，由国家专家领导 在各自的领域。它们包括核心：糖尿病研究中的传播和实施； 政策和系统科学分析；健康传播和社会需求；健康信息学 糖尿病研究(地区资源)；美国黑人糖尿病解决方案(国家资源)。 我们还赞助了一个非常成功的试点和可行性计划，重点放在早期和以下阶段- 有代表性的少数族裔调查人员和充满活力的充实计划，该计划加强了教育和 有糖尿病翻译研究的意识。WU-CDTR提高了效率、生产力和快速 在全国研究人员网络中进行研究翻译，同时促进合作以实现 糖尿病健康公平。

PROJECT SUMMARY/ABSTRACT – Overview This is an application for the continuation of the Washington University Center for Diabetes Translation Research (WU-CDTR). The Center is guided by our strategic vision in which a health equity lens is the foundation for transformative diabetes research translated into action and impact. This equity-driven vision informs our Center mission to be the nexus for transdisciplinary team science in advancing the conduct of the next generation of diabetes translation research. Our goal is to advance a rigorous, scientific evidence base to inform the dissemination, implementation, and sustainability of efficacious interventions for populations at risk for diabetes disparities. The WU-CDTR is the intellectual home to an outstanding network of investigators who conduct research on the root causes of diabetes inequities, informed by social determinants of health and organized around five thematic areas: biobehavioral discovery; living and working conditions; health care context; health information and technology environment; and community, policy and systems research. The research base consists of 87 investigators (66 Full Members and 21 Associate Members) from within Washington University, and 21 different universities with members affiliated through our Regional and National Resource Cores (Department of Health Management and Informatics at the University of Missouri in Columbia; and the Council on Black Health at Drexel University in Pennsylvania, respectively). Our research base is defined by established (69%) and new diabetes investigators (31%), as well as those from underrepresented minority populations (38%); members work in collaboration with a network of multi-sectoral partners (N=73) including healthcare and non-health care organizations. From 2016 to present, WU-CDTR investigators were awarded $243.2 million in total direct costs and $66.8 million in annual direct costs. This includes 86 current and ongoing Center supported grants generating $173.3 million in total direct costs and $40.7 million in annual direct costs; 65% of WU-CDTR Full Members have NIH funding, and 80% of total grant support is from federal sources. The WU-CDTR is organized around five novel Translational Research Cores, led by national experts in their respective fields. They include cores on: Dissemination and Implementation in Diabetes Research; Policy and Systems Science Analysis; Health Communication and Social Needs; Health Informatics in Diabetes Research (Regional Resource); and Solutions to Diabetes in Black Americans (National Resource). We also sponsor a very successful Pilot and Feasibility Program focused on early stage and under- represented minority investigators and a vibrant Enrichment Program, which enhances education and awareness of diabetes translation research. The WU-CDTR enhances efficiency, productivity, and rapid research translation across a national network of investigators while fostering collaborations to achieve diabetes health equity.