The Washington University Center for Diabetes Translation Research

项目概要/摘要-概述 这是华盛顿大学糖尿病翻译中心的延续申请 研究（WU-CDTR）。该中心以我们的战略愿景为指导，其中健康公平透镜是 将糖尿病研究转化为行动和影响。这种以股权为导向的愿景 通知我们的中心使命是跨学科团队科学的纽带，在推进 下一代糖尿病翻译研究。我们的目标是推进一个严格的，科学的证据基础， 为风险人群有效干预措施的传播、实施和可持续性提供信息 糖尿病的差异。WU-CDTR是一个杰出的调查人员网络的知识之家， 根据健康的社会决定因素，对糖尿病不平等的根源进行研究， 围绕五个主题领域组织：生物行为发现;生活和工作条件;医疗保健 环境;卫生信息和技术环境;以及社区、政策和系统研究。的 研究基地由87名研究人员（66名正式成员和21名准成员）组成， 华盛顿大学，以及21所不同的大学，其成员通过我们的区域和国家 资源核心（哥伦比亚的密苏里州大学健康管理和信息学系; 和宾夕法尼亚州德雷克塞尔大学黑人健康理事会）。我们的研究基地是 由已建立的（69%）和新的糖尿病研究者（31%）以及代表性不足的研究者定义 少数民族人口（38%）;成员与多部门合作伙伴网络合作（N=73） 包括医疗保健和非医疗保健组织。从2016年至今，WU-CDTR研究人员 直接费用总额为2.432亿美元，年度直接费用为6 680万美元。目前，86 和正在进行的中心支持赠款产生1.733亿美元的直接费用总额和4070万美元的年度 直接成本; 65%的WU-CDTR正式成员获得NIH资助，总资助支持的80%来自联邦 源WU-CDTR围绕五个新颖的翻译研究核心组织，由国家专家领导 在各自领域它们包括核心：糖尿病研究的传播和实施; 政策与系统科学分析;健康传播与社会需求; 糖尿病研究（区域资源）;和解决方案糖尿病在美国黑人（国家资源）。 我们还赞助了一个非常成功的试点和可行性计划，重点是早期阶段和下- 代表少数民族调查人员和一个充满活力的丰富计划，提高教育和 认识糖尿病翻译研究。WU-CDTR提高了效率、生产力和快速 在全国调查人员网络中进行研究翻译，同时促进合作， 糖尿病健康公平

PROJECT SUMMARY/ABSTRACT – Overview This is an application for the continuation of the Washington University Center for Diabetes Translation Research (WU-CDTR). The Center is guided by our strategic vision in which a health equity lens is the foundation for transformative diabetes research translated into action and impact. This equity-driven vision informs our Center mission to be the nexus for transdisciplinary team science in advancing the conduct of the next generation of diabetes translation research. Our goal is to advance a rigorous, scientific evidence base to inform the dissemination, implementation, and sustainability of efficacious interventions for populations at risk for diabetes disparities. The WU-CDTR is the intellectual home to an outstanding network of investigators who conduct research on the root causes of diabetes inequities, informed by social determinants of health and organized around five thematic areas: biobehavioral discovery; living and working conditions; health care context; health information and technology environment; and community, policy and systems research. The research base consists of 87 investigators (66 Full Members and 21 Associate Members) from within Washington University, and 21 different universities with members affiliated through our Regional and National Resource Cores (Department of Health Management and Informatics at the University of Missouri in Columbia; and the Council on Black Health at Drexel University in Pennsylvania, respectively). Our research base is defined by established (69%) and new diabetes investigators (31%), as well as those from underrepresented minority populations (38%); members work in collaboration with a network of multi-sectoral partners (N=73) including healthcare and non-health care organizations. From 2016 to present, WU-CDTR investigators were awarded $243.2 million in total direct costs and $66.8 million in annual direct costs. This includes 86 current and ongoing Center supported grants generating $173.3 million in total direct costs and $40.7 million in annual direct costs; 65% of WU-CDTR Full Members have NIH funding, and 80% of total grant support is from federal sources. The WU-CDTR is organized around five novel Translational Research Cores, led by national experts in their respective fields. They include cores on: Dissemination and Implementation in Diabetes Research; Policy and Systems Science Analysis; Health Communication and Social Needs; Health Informatics in Diabetes Research (Regional Resource); and Solutions to Diabetes in Black Americans (National Resource). We also sponsor a very successful Pilot and Feasibility Program focused on early stage and under- represented minority investigators and a vibrant Enrichment Program, which enhances education and awareness of diabetes translation research. The WU-CDTR enhances efficiency, productivity, and rapid research translation across a national network of investigators while fostering collaborations to achieve diabetes health equity.