Quantifying and Understanding Indirect Genetic Effects on Alzheimer's Disease

联系PD/PI：Fletcher，Jason M 项目摘要 这是一项继续支持健康和老龄人口统计中心(CDHA)的提案 威斯康星大学麦迪逊分校。CDHA的总体目标是维持和改进一项重大研究和 健康和老龄化人口统计学方面的培训方案。CDHA的机构架构是 旨在建立社会人口学、经济学、生物医学和流行病学研究之间的联系 关于健康和衰老。CDHA正在进行的和发展中的研究活动的主要主题包括 1)老龄化与生命历程；(2)生物人口学，包括数据收集和分析工作 生物标志物、基因-环境相互作用和微生物组；(3)社会人口学的决定因素 老龄化轨迹的差异；(4)评估护理的组织、技术、政策和提供情况；以及 (5)场所对健康和老龄化的影响。CDHA是麻省理工学院内的一个独立研究单位 与人口学和生态学中心共存的字母和科学。因此，它共享和 在行政、计算设施和数据库方面扩展完善的研究基础设施， 和传播能力。CDHA的行政核心(A)提供领导和行政 对整个中心的支持，特别是对核心B的活动的支持。方案开发核心(B) 支持从事创新、高风险先导研究项目的教职员工和研究助理 很可能会得到NIA的重大支持。外部创新网络核心(C)将继续高度 成功和流行的、联网的当前认识服务，用于健康和人口统计学研究 老龄化和支持定期的研讨会、会议和访问。外部研究资源核心(D) 支持对卫生人口统计中的大规模公共和受限使用数据资源进行分析 并传播重要的研究成果。远程数据飞地(E)支持 在安全条件下分析敏感数据，并与最先进的联邦统计局集成 威斯康星大学麦迪逊分校的研究数据中心设施。 第324页 项目摘要/摘要

Contact PD/PI: Fletcher, Jason M Project Summary This is a proposal for continuing support of the Center for Demography of Health and Aging (CDHA) at the University of Wisconsin-Madison. The overall goal of CDHA is to sustain and improve a major research and training program in the demography of health and aging. The institutional architecture of CDHA is designed to create links between social demography, economics, biomedical and epidemiological research on health and aging. Major themes of ongoing and developmental research activities within CDHA include 1) Aging and the Life Course; (2) Biodemography, including data collection and analytical work with biomarkers, gene-environment interactions and the microbiome; (3) Determinants of sociodemographic disparities of aging trajectories; (4) Assessing the organization, technology, policy, and delivery of care; and (5) Place-based impacts on health and aging. CDHA is an autonomous research unit within the College of Letters and Science where it coexists with the Center for Demography and Ecology. It thus shares and extends a well-developed research infrastructure in administration, computing facilities and data library, and dissemination capacity. CDHA’s Administrative Core (A) provides leadership and administrative support for the Center as a whole, particularly for activities of Core B. The Program Development Core (B) supports faculty, staff, and research assistants engaged in innovative, high-risk pilot research projects that are likely to lead to major NIA support. The External Innovative Network Core (C) will continue a highly successful and popular, networked current awareness service for research in the demography of health and aging and support regular workshops, conferences, and visits. The External Research Resources Core (D) supports the analysis of large-scale public and restricted-use data resources in the demography of health and aging and disseminates important research findings. The Remote Data Enclave (E) supports the analysis of sensitive data under secure conditions and integrates with a state-of-the art Federal Statistical Research Data Center facility on the UW-Madison campus. Page 324 Project Summary/Abstract