Quantifying and Understanding Indirect Genetic Effects on Alzheimer's Disease

量化和理解遗传对阿尔茨海默病的间接影响

• 批准号: 10289068
• 负责人: Jason Michael Fletcher
• 金额: $ 32.38万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10289068
• 关键词: Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; American; Amyloid; Architecture; Atlases; Awareness; Behavioral; Biological; Biological Markers; Biological Process; Biomedical Research; Cerebrospinal Fluid; Child; Clinical; Cognition; Cognitive; Communities; Complex; Data; Data Analytics; Data Collection; Demography; Development; Disease; Disease Outcome; Ecology; Economics; Educational workshop; Environment; Etiology; Family; Family member; Generations; Genetic; Genetic Determinism; Genetic Diseases; Genetic Processes; Genetic Research; Genetic Risk; Genome; Genotype; Goals; Health; Health Sciences; Health Services Research; Health and Retirement Study; Hippocampus (Brain); Individual; Joints; Knowledge; Lead; Leadership; Letters; Life Cycle Stages; Light; Link; Mediating; Methods; Neurodegenerative Disorders; Parents; Persons; Phenotype; Policies; Population; Process; Program Development; Recording of previous events; Research; Research Activity; Research Assistant; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Respondent; Role; Science; Secure; Siblings; Social Sciences; Spouses; Statistical Methods; Techniques; Technology; Testing; Training Programs; United States National Institutes of Health; Universities; Use of New Techniques; Visit; Wisconsin; Work; amyloid imaging; base; biobank; biodemography; care delivery; college; data archive; data centers; data enclave; data resource; design; epidemiology study; faculty support; gene environment interaction; genetic association; genetic variant; genome sciences; genome wide association study; genome-wide; genome-wide analysis; genomic locus; high risk; improved; innovation; insight; interest; microbiome; multiple data sources; novel; offspring; phenome; phenotypic data; social; social genomics; sociodemographics; socioeconomics; statistics; symposium; tau Proteins; trait

Contact PD/PI: Fletcher, Jason M Project Summary This is a proposal for continuing support of the Center for Demography of Health and Aging (CDHA) at the University of Wisconsin-Madison. The overall goal of CDHA is to sustain and improve a major research and training program in the demography of health and aging. The institutional architecture of CDHA is designed to create links between social demography, economics, biomedical and epidemiological research on health and aging. Major themes of ongoing and developmental research activities within CDHA include 1) Aging and the Life Course; (2) Biodemography, including data collection and analytical work with biomarkers, gene-environment interactions and the microbiome; (3) Determinants of sociodemographic disparities of aging trajectories; (4) Assessing the organization, technology, policy, and delivery of care; and (5) Place-based impacts on health and aging. CDHA is an autonomous research unit within the College of Letters and Science where it coexists with the Center for Demography and Ecology. It thus shares and extends a well-developed research infrastructure in administration, computing facilities and data library, and dissemination capacity. CDHA’s Administrative Core (A) provides leadership and administrative support for the Center as a whole, particularly for activities of Core B. The Program Development Core (B) supports faculty, staff, and research assistants engaged in innovative, high-risk pilot research projects that are likely to lead to major NIA support. The External Innovative Network Core (C) will continue a highly successful and popular, networked current awareness service for research in the demography of health and aging and support regular workshops, conferences, and visits. The External Research Resources Core (D) supports the analysis of large-scale public and restricted-use data resources in the demography of health and aging and disseminates important research findings. The Remote Data Enclave (E) supports the analysis of sensitive data under secure conditions and integrates with a state-of-the art Federal Statistical Research Data Center facility on the UW-Madison campus. Page 324 Project Summary/Abstract

联系PD/PI：弗莱彻、Jason M 项目摘要 这是一项关于继续支持健康和老龄人口统计学中心（CDHA）的建议， 威斯康星大学麦迪逊分校CDHA的总体目标是维持和改善一项重大研究， 健康和老龄人口学培训方案。CDHA的体制结构是 旨在建立社会人口学、经济学、生物医学和流行病学研究之间的联系 关于健康和老龄化。CDHA内正在进行和发展的研究活动的主要主题包括 1)（2）生物人口学，包括数据收集和分析工作， 生物标志物，基因-环境相互作用和微生物组;（3）社会人口统计学的决定因素 老龄化轨迹的差异;（4）评估组织，技术，政策和护理的提供;以及 (5)基于地点的对健康和老龄化的影响。CDHA是学院内的一个自主研究单位， 它与人口与生态中心共存。因此，它分享和 在行政、计算设施和数据库方面扩展了一个发展良好的研究基础设施， 传播能力。CDHA的行政核心（A）提供领导和行政 支持整个中心，特别是核心B的活动。程序开发核心（B） 支持教师，工作人员和研究助理从事创新，高风险的试点研究项目， 可能会得到NIA的大力支持。外部创新网络核心（C）将继续高度 成功和流行的，网络化的当前认识服务，用于健康人口学研究， 老龄化和支持定期讲习班，会议和访问。外部研究资源核心（D） 支持分析卫生人口统计学中的大规模公共和限制使用的数据资源 并传播重要的研究成果。远程数据飞地（E）支持 在安全的条件下分析敏感数据，并与最先进的联邦统计 研究数据中心设施在威斯康星大学麦迪逊分校校园。 页324 项目总结/摘要