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Biomarkers Core RC3

生物标志物核心 RC3

基本信息

批准号：
10294032
负责人：
Laura Haynes
金额：
$ 22.42万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10294032
关键词：
Address Adoption African American Aging American Animal Model Behavior Therapy Biological Biological Aging Biological Assay Biological Markers COVID-19 Capsicum Chronic Disease Clinical Trials Communities Core Facility Data Analyses Data Collection Databases Development Disease Elderly Ensure Experimental Designs Familiarity Funding Future Genomic medicine Genomics Gerontology Goals Health Heterogeneity Human Immunology Individual Intervention Laboratories Lead Major Depressive Disorder Measurement Metabolism Methods Molecular Mus Online Systems Outcome Participant Peripheral Blood Mononuclear Cell Phenotype Physical Function Pilot Projects Postdoctoral Fellow Pre-Clinical Model Protocols documentation Research Research Personnel Research Support Resources Sampling Scientist Services Specialist Systems Biology Techniques Technology The Jackson Laboratory Tissues Translations Validation Work bench to bedside biobank biological heterogeneity biomarker discovery biomarker identification cohort data resource data streams disability experience frailty functional genomics functional outcomes human model human subject immune function improved infectious disease model metabolomics novel pre-clinical professor protocol development ranpirnase resilience single-cell RNA sequencing specific biomarkers success tool transcriptomics

项目摘要

RC3 Project Summary The goal of the RC3 Biomarkers and Preclinical Core is to provide UConn Pepper Center (OAIC) trainees, pilot and developmental project investigators and the broader scientific community with expertise and tools needed to interrogate biomarkers, drivers of aging and underlying mechanisms of chronic diseases in humans and animal models in order to promote function and independence in late life. Research supported by RC3 will advance these UConn OAIC goals by emphasizing approaches derived from precision gerontology, our thematic focus. To that end, RC3 will emphasize approaches and technologies capable of defining biological heterogeneity in a manner that can lead to biomarker discovery and improved targeting of interventions. RC3 will offer investigators guidance with coordinated access to existing UConn Health and Jackson Lab cores and resources. For investigators lacking deep familiarity with specific methods, advice and assistance will be offered in terms of project development to determine best approaches, assays and analyses for their proposed studies. RC3 will also provide biomarker analysis for all human subjects who participate in UConn OAIC studies. The Specific Aims are: (1) Assist investigators in the development of experimental protocols involving biomarkers of aging and related conditions such as chronic diseases, resilience, frailty and disability to achieve the goals of each project; (2) Facilitate interaction between investigators, established core facilities and RC2 Data Resource Core in order to achieve the goals for evaluating biological heterogeneity in each project; (3) Development of a biobank and biomarker discovery.

RC3项目总结