Biomarkers Core RC3

生物标志物核心 RC3

• 批准号: 10294032
• 负责人: Laura Haynes
• 金额: $ 22.42万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294032
• 关键词: Address; Adoption; African American; Aging; American; Animal Model; Behavior Therapy; Biological; Biological Aging; Biological Assay; Biological Markers; COVID-19; Capsicum; Chronic Disease; Clinical Trials; Communities; Core Facility; Data Analyses; Data Collection; Databases; Development; Disease; Elderly; Ensure; Experimental Designs; Familiarity; Funding; Future; Genomic medicine; Genomics; Gerontology; Goals; Health; Heterogeneity; Human; Immunology; Individual; Intervention; Laboratories; Lead; Major Depressive Disorder; Measurement; Metabolism; Methods; Molecular; Mus; Online Systems; Outcome; Participant; Peripheral Blood Mononuclear Cell; Phenotype; Physical Function; Pilot Projects; Postdoctoral Fellow; Pre-Clinical Model; Protocols documentation; Research; Research Personnel; Research Support; Resources; Sampling; Scientist; Services; Specialist; Systems Biology; Techniques; Technology; The Jackson Laboratory; Tissues; Translations; Validation; Work; bench to bedside; biobank; biological heterogeneity; biomarker discovery; biomarker identification; cohort; data resource; data streams; disability; experience; frailty; functional genomics; functional outcomes; human model; human subject; immune function; improved; infectious disease model; metabolomics; novel; pre-clinical; professor; protocol development; ranpirnase; resilience; single-cell RNA sequencing; specific biomarkers; success; tool; transcriptomics

RC3 Project Summary The goal of the RC3 Biomarkers and Preclinical Core is to provide UConn Pepper Center (OAIC) trainees, pilot and developmental project investigators and the broader scientific community with expertise and tools needed to interrogate biomarkers, drivers of aging and underlying mechanisms of chronic diseases in humans and animal models in order to promote function and independence in late life. Research supported by RC3 will advance these UConn OAIC goals by emphasizing approaches derived from precision gerontology, our thematic focus. To that end, RC3 will emphasize approaches and technologies capable of defining biological heterogeneity in a manner that can lead to biomarker discovery and improved targeting of interventions. RC3 will offer investigators guidance with coordinated access to existing UConn Health and Jackson Lab cores and resources. For investigators lacking deep familiarity with specific methods, advice and assistance will be offered in terms of project development to determine best approaches, assays and analyses for their proposed studies. RC3 will also provide biomarker analysis for all human subjects who participate in UConn OAIC studies. The Specific Aims are: (1) Assist investigators in the development of experimental protocols involving biomarkers of aging and related conditions such as chronic diseases, resilience, frailty and disability to achieve the goals of each project; (2) Facilitate interaction between investigators, established core facilities and RC2 Data Resource Core in order to achieve the goals for evaluating biological heterogeneity in each project; (3) Development of a biobank and biomarker discovery.

RC 3项目摘要 RC 3生物标志物和临床前核心的目标是为康州大学胡椒中心（OAIC）的学员，试点 和发展项目调查人员以及更广泛的科学界提供所需的专业知识和工具 询问生物标志物，衰老的驱动因素和人类慢性疾病的潜在机制， 动物模型，以促进晚年的功能和独立性。RC 3支持的研究将 通过强调来自精确老年学的方法来推进这些康州大学OAIC目标，我们的主题 专心点为此，RC 3将强调能够界定生物多样性的方法和技术， 在某些情况下，可以以可以导致生物标志物发现和改善干预的靶向的方式来检测异质性。RC3 将为研究人员提供指导，协调访问现有的康州大学健康和杰克逊实验室核心， 资源对于不太熟悉具体方法的调查人员，将提供咨询和协助 在项目开发方面，为拟议的研究确定最佳方法、化验和分析。 RC 3还将为参与UConn OAIC研究的所有人类受试者提供生物标志物分析。的 具体目的是：（1）协助研究者开发涉及以下生物标志物的实验方案： 老龄化和慢性病、复原力、虚弱和残疾等相关状况，以实现 每个项目;（2）促进研究人员、既定核心设施和RC 2数据资源之间的互动 核心，以实现评价生物异质性的目标，在每个项目中;（3）开发一个 生物库和生物标志物发现。