Biomarkers Core RC3

生物标志物核心 RC3

• 批准号: 10294032
• 负责人: Laura Haynes
• 金额: $ 22.42万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294032
• 关键词: Address; Adoption; African American; Aging; American; Animal Model; Behavior Therapy; Biological; Biological Aging; Biological Assay; Biological Markers; COVID-19; Capsicum; Chronic Disease; Clinical Trials; Communities; Core Facility; Data Analyses; Data Collection; Databases; Development; Disease; Elderly; Ensure; Experimental Designs; Familiarity; Funding; Future; Genomic medicine; Genomics; Gerontology; Goals; Health; Heterogeneity; Human; Immunology; Individual; Intervention; Laboratories; Lead; Major Depressive Disorder; Measurement; Metabolism; Methods; Molecular; Mus; Online Systems; Outcome; Participant; Peripheral Blood Mononuclear Cell; Phenotype; Physical Function; Pilot Projects; Postdoctoral Fellow; Pre-Clinical Model; Protocols documentation; Research; Research Personnel; Research Support; Resources; Sampling; Scientist; Services; Specialist; Systems Biology; Techniques; Technology; The Jackson Laboratory; Tissues; Translations; Validation; Work; bench to bedside; biobank; biological heterogeneity; biomarker discovery; biomarker identification; cohort; data resource; data streams; disability; experience; frailty; functional genomics; functional outcomes; human model; human subject; immune function; improved; infectious disease model; metabolomics; novel; pre-clinical; professor; protocol development; ranpirnase; resilience; single-cell RNA sequencing; specific biomarkers; success; tool; transcriptomics

RC3 Project Summary The goal of the RC3 Biomarkers and Preclinical Core is to provide UConn Pepper Center (OAIC) trainees, pilot and developmental project investigators and the broader scientific community with expertise and tools needed to interrogate biomarkers, drivers of aging and underlying mechanisms of chronic diseases in humans and animal models in order to promote function and independence in late life. Research supported by RC3 will advance these UConn OAIC goals by emphasizing approaches derived from precision gerontology, our thematic focus. To that end, RC3 will emphasize approaches and technologies capable of defining biological heterogeneity in a manner that can lead to biomarker discovery and improved targeting of interventions. RC3 will offer investigators guidance with coordinated access to existing UConn Health and Jackson Lab cores and resources. For investigators lacking deep familiarity with specific methods, advice and assistance will be offered in terms of project development to determine best approaches, assays and analyses for their proposed studies. RC3 will also provide biomarker analysis for all human subjects who participate in UConn OAIC studies. The Specific Aims are: (1) Assist investigators in the development of experimental protocols involving biomarkers of aging and related conditions such as chronic diseases, resilience, frailty and disability to achieve the goals of each project; (2) Facilitate interaction between investigators, established core facilities and RC2 Data Resource Core in order to achieve the goals for evaluating biological heterogeneity in each project; (3) Development of a biobank and biomarker discovery.

RC3项目摘要 RC3生物标志物和临床前核心的目标是提供UConn Pepper Center（OAIC）受训者，飞行员 以及开发项目调查人员和更广泛的科学界，具有所需的专业知识和工具 询问生物标志物，衰老的驱动因素和人类慢性疾病的潜在机制 动物模型以促进后期的功能和独立性。 RC3支持的研究将 通过强调从精密老年病（我们的主题）得出的方法来推进这些UConn OAIC 重点。为此，RC3将强调能够定义生物学的方法和技术 异质性以可能导致生物标志物发现并改善干预措施的靶向靶向的方式。 RC3 将为调查人员提供指导，并协调访问现有的UConn Health和Jackson Lab核心以及 资源。对于缺乏对特定方法的调查人员，将提供建议和帮助 在项目开发方面，以确定其拟议研究的最佳方法，测定和分析。 RC3还将为参加UConn OAIC研究的所有人类受试者提供生物标志物分析。这 具体目的是：（1）协助研究人员制定涉及生物标志物的实验方案 衰老和相关疾病，例如慢性疾病，韧性，脆弱和残疾，以实现目标 每个项目； （2）促进研究人员，既定设施和RC2数据资源之间的互动 为了实现评估每个项目生物异质性的目标的核心； （3）发展 生物库和生物标志物发现。