ANIMAL BREEDING

老鼠提供了一个经过充分研究的同质种群，可以很容易地被操纵，用于测试年龄对免疫系统的影响的实验。通过使用小鼠模型来研究衰老，我们可以很容易地检查免疫系统的不同成分。此外，基因操纵的小鼠模型的可获得性将使我们能够一次研究年龄对单个参数的影响。这个核心设施将提供特鲁多研究所动物设施目前没有提供的服务。核心B的具体目标将是：(1)产生一群健康的老年小鼠-核心将确保老年小鼠保持在通风架上，并进行每月健康筛查；(2)产生新的近交系 转基因小鼠-核心将根据每个研究人员的需要，将基因敲除和转基因小鼠回交到适当的遗传背景。该核心还将确保该计划中的调查人员所需的所有老鼠都得到及时的筛查。然后，每个研究人员都可以购买这些小鼠。

Mice provide a well-studied homogeneous population that can be manipulated readily for experiments examining the effect of age on the immune system. By using murine models to study aging, we can easily examine different components of the immune system. Furthermore, the availability of genetically manipulated mouse models will allow us to study the effect of age on a single parameter at a time. This Core Facility will provide services not currently provided by the Trudeau Institute animal facility. The specific aims of Core B will be: (1) generation of a colony of healthy aged mice - the Core will ensure that aged mice are maintained on ventilated racks and that monthly health screenings are performed; (2) generation of new inbred strains of genetically altered mice - the Core will backcross knockout and transgenic mice onto appropriate genetic backgrounds, as needed by each investigator. This Core will also ensure that all mice needed by the investigators in the Program are screened in a timely manner. These mice can then be purchased by each investigator.