Nickel Catalyzed Electrochemical C-C Cross-Coupling Reactions
Nickel Catalyzed Electrochemical C-C Cross-Coupling Reactions
批准号:
10291901
负责人:
Tianbiao Liu
金额:
$43.7万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-01 至 2024-07-31
关键词:
AdoptionAirAminesAmino AcidsAnodesBromidesCarbonCatalysisCathodesCellsChemicalsChemistryChloridesCouplingDevelopmentEconomicsEducationElectron TransportFutureGoalsGrantHealthHealth SciencesHumanIndustrializationKineticsKnowledgeLigandsLiteratureMediatingMentorsMetalsModificationNative AmericansNickelOrganic SynthesisOxidation-ReductionPalladiumPharmacologic SubstanceReactionReagentResearchResearch ActivitySocietiesStudentsSustainable DevelopmentTechnologyTestingThermodynamicsTrainingTransition ElementsUnited States National Institutes of HealthVisionaryl halidebasecarboxylatecareercatalystcomputer studiescostexperimental studygraduate studentinterfacialoperationoxidationscale upsuccessundergraduate research experienceundergraduate student
中文摘要
项目总结。本计划书描述Liu (PI)和Ess (co-PI)的合作研究活动。
英文摘要
Project Summary. This proposal describes the collaborative research activities by Liu (PI) and Ess (co-PI)
towards developing highly effective, sustainable, green Nickel (Ni) catalyzed electrochemical cross-coupling
reactions for synthetic applications in making pharmaceuticals and bioactive molecules, and integrated education
activities aimed at promoting research experiences of undergraduate, and graduate students. Special emphases
will be placed on attracting and training underrepresented Native American students. The new knowledge
obtained from this proposed research will provide guidance in developing competent and atomically economic
electrosynthesis approaches for their utilization in developing pharmaceuticals and bioactive molecules, thereby
enhancing human health and enabling the sustainable development of our society.
Herein, we propose that redox neutral electrochemical C?C cross-coupling reactions can be accomplished
in an undivided cell configuration using bench-stable electrophiles (aryl halide, alkenyl halides, and alkynyl
halides) and nucleophiles (organic trifluoroborate, carboxylates, and amines), non-precious, bench-stable
catalysts consisting of a NiII pre-catalyst and polypyridine ligands under ambient conditions. Preliminary studies
have confirmed the broad reaction scope and good yields of the Ni-catalyzed electrochemical coupling reactions
by 50 examples of aryl/β-styrenyl chloride/bromide and benzyl trifluoroborates. Their potential applications were
demonstrated by electrosynthesis and late-stage functionalization of pharmaceuticals, natural amino acid
modification, and scalable synthesis using a flow-cell electrolyzer.
In the future, we plan to expand the substrate scopes of both electrophiles and nucleophiles and further
develop the flow-cell electrolyzer technology to achieve optimal reaction efficiency and scalable synthesis. In
addition, we will conduct comprehensive experimental and computational studies to gain in-depth mechanistic
understandings. This electrochemical C?C cross-coupling paradigm is expected to be highly productive and
atomically economic and will find wide-spread applications in developing pharmaceuticals and bioactive
molecules. The knowledge gained will have broad impacts on developing other metal based (e.g. Fe, and Co)
and even metal free electrochemical C-C, C-N, and C-O, and C-S coupling reactions and other electrochemical
organic transformations. In addition, this proposal will provide rich research opportunities for undergraduate
students (particularly for Native American undergraduate students) that will enlarge their career vision in health
sciences. This AREA grant is essential to the PI’s lab and to providing research and mentoring opportunities for
undergraduate and graduate students.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Chloride-mediated electrochemical synthesis of oxazolines.
氯化物介导的恶唑啉电化学合成。
DOI:
10.1016/j.checat.2021.10.003
发表时间:
2021
期刊:
Chem catalysis
影响因子:
--
作者:
[Wu,Wenda, Li,Gang, Liu,TLeo]
通讯作者:
Liu,TLeo
国内基金
海外基金
湍流和化学交互作用对H2-Air-H2O微混燃烧中NO生成的影响研究
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批准号:51976048
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项目类别:面上项目
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资助金额:61.0万元
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批准年份:2019
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负责人:邱朋华
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依托单位: