Improving Genetic Counseling for BRCA+ Mothers

改善 BRCA 母亲的遗传咨询

• 批准号: 10292670
• 负责人: BETH N PESHKIN
• 金额: $ 6.08万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-02 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292670
• 关键词: Academic Medical Centers; Administrative Supplement; Area; Behavioral; Behavioral Research; Behavioral Sciences; Breast Cancer Risk Factor; Cancer Control; Cancer Control Research; Cancer Survivor; Child; Clinical; Communication; Competence; Comprehensive Cancer Center; Data; Disadvantaged; Distress; Doctor of Philosophy; Exposure to; Family; Fellowship; Genetic; Genetic Counseling; Goals; Growth; Health; Health behavior; Hereditary Breast Carcinoma; Inherited; Intervention; Journals; K-Series Research Career Programs; Lead; Learning; Longevity; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Methodology; Mothers; Outcome; Parents; Peer Review; Personal Satisfaction; Persons; Population Heterogeneity; Positioning Attribute; Postdoctoral Fellow; Preparation; Public Health; Publications; Recording of previous events; Research; Research Methodology; Research Personnel; Testing; Training; United States National Institutes of Health; Universities; behavioral outcome; behavioral study; cancer health disparity; cancer prevention; cancer risk; carrier status; experience; genetic testing; health related quality of life; improved; interest; meetings; professor; programs; psychologic; psychosocial; social; sociodemographics; theories; virtual

Project Abstract The purpose of this NIH/NCI administrative supplement to R01CA246589 is to provide support, mentorship, and training to Glynnis McDonnell, PhD, as a postdoctoral fellow under the mentorship of Kenneth Tercyak and Beth Peshkin at Georgetown University's Lombardi Comprehensive Cancer Center, Cancer Prevention and Control Program. Over a two-year period, this fellowship will promote the applicant's/fellow's growth as an independent behavioral science researcher in the area of cancer control and prevention with a focus on family communication through six major activities: 1) mentored research experiences with the parent study team; 2) advanced training in mixed-methods research (qualitative-quantitative analysis of behavioral data) to advance outcomes of genetic counseling; 3) participation in didactic opportunities through Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, and the Cancer Prevention and Control Program; 4) attendance at national scientific meetings (virtual, or in-person when resumed); 5) preparation of manuscripts for publication in peer-reviewed journals, and; 6) developing and submitting an NIH/NCI research career development award application to extend the learning. This supplement opportunity will also allow the applicant to enhance her competencies in behavioral research theory and methodology through exposure to the parent study’s RCT research implementation, and help develop expertise in the content area of genetic counseling interventions for families at high breast cancer risk. With interests in psychosocial kinship factors influencing health behaviors across the lifespan, the applicant aims to: 1) characterize mothers’ perspectives about the social and psychological advantages and disadvantages of communicating with children about BRCA genetic testing, inherited cancer risks, and cancer prevention, and 2) examine associations among maternal BRCA carrier status and cancer history with mother-child distress, as well as sociodemographic moderators of distress. Given well-established disparities in cancer outcomes, and the potential for genetics to transform clinical and public health approaches to cancer risk identification and management, the proposed training plan is significant because it will inform Healthy People 2030 goals surrounding genetic counseling for hereditary breast cancer, increasing the health-related quality of life of cancer survivors, and doing so equitably across diverse populations. After training, the applicant will be positioned to lead high-impact research in this area.

项目摘要 NIH/NCI 对 R01CA246589 的行政补充的目的是提供支持、指导、 并在 Kenneth Tercyak 的指导下接受 Glynnis McDonnell 博士的博士后培训 Beth Peshkin，乔治城大学隆巴迪综合癌症中心，癌症预防和 控制程序。在两年的时间内，该奖学金将促进申请人/研究员作为一名 癌症控制和预防领域的独立行为科学研究人员，重点关注家庭 通过六大活动进行沟通：1）与家长研究团队指导研究经验； 2） 混合方法研究（行为数据的定性定量分析）的高级培训，以推进 遗传咨询的结果； 3）通过乔治城大学参与教学机会 医疗中心、隆巴迪综合癌症中心和癌症预防和控制计划； 4） 出席国家科学会议（虚拟会议，或恢复后亲自参加）； 5）稿件准备 在同行评审期刊上发表，以及； 6) 开发并提交 NIH/NCI 研究生涯 申请发展奖以扩展学习。这个补充机会也将使申请人 通过接触家长来提高她在行为研究理论和方法方面的能力 研究的随机对照试验研究实施，并帮助发展遗传咨询内容领域的专业知识 针对乳腺癌高风险家庭的干预措施。对影响心理社会亲缘因素的兴趣 整个生命周期的健康行为，申请人的目标是：1）描述母亲对 与儿童沟通 BRCA 遗传的社会和心理优势和劣势 检测、遗传性癌症风险和癌症预防，2) 检查母亲 BRCA 之间的关联 携带者状况和癌症病史以及母子痛苦，以及社会人口学调节因素 苦恼。鉴于癌症结果的明显差异以及遗传学改变的潜力 癌症风险识别和管理的临床和公共卫生方法、拟议的培训计划 意义重大，因为它将为“健康人 2030”围绕遗传性遗传咨询的目标提供信息 乳腺癌，提高癌症幸存者的健康相关生活质量，并在各个领域公平地这样做 不同的人群。培训结束后，申请人将负责领导该领域的高影响力研究。