Improving Genetic Counseling for BRCA+ Mothers

项目摘要 NIH/NCI对R 01 CA 246589的行政补充的目的是提供支持、指导， 并培训Glynnis McDonnell博士，作为Kenneth Tercyak指导下的博士后研究员， 乔治敦大学伦巴第综合癌症中心的贝丝·佩什金，癌症预防和 控制程序。在两年的时间里，该奖学金将促进申请人/研究员的成长， 癌症控制和预防领域的独立行为科学研究员，重点关注家庭 通过六个主要活动进行交流：1）与家长研究团队一起指导研究经验; 2） 混合方法研究的高级培训（行为数据的定性-定量分析）， 遗传咨询的结果; 3）通过乔治敦大学参与教学机会 医疗中心、隆巴迪综合癌症中心和癌症预防和控制方案; 4） 参加国家科学会议（虚拟会议，或恢复时亲自出席）; 5）编写手稿 在同行评议的期刊上发表，以及; 6）开发和提交NIH/NCI研究生涯 发展奖的应用，以扩大学习。这一补充机会也将允许申请人 通过接触父母，提高她在行为研究理论和方法方面的能力 研究的RCT研究实施，并帮助发展遗传咨询内容领域的专业知识 为乳腺癌高危家庭提供干预措施。与利益的心理社会亲属因素的影响 在整个生命周期的健康行为，申请人的目的是：1）表征母亲的观点， 与儿童沟通BRCA遗传学的社会和心理优势和劣势 检测，遗传性癌症风险和癌症预防，以及2）检查母体BRCA之间的关联 携带者状态和癌症史与母子痛苦，以及社会人口学的调节因素， 痛苦考虑到癌症结果的明显差异，以及遗传学改变的潜力， 癌症风险识别和管理的临床和公共卫生方法， 这是重要的，因为它将告知健康的人2030年的目标，围绕遗传咨询， 乳腺癌，提高癌症幸存者与健康相关的生活质量，并在各个领域公平地这样做。 不同的人群。培训后，申请人将被定位为领导该领域的高影响力研究。

Project Abstract The purpose of this NIH/NCI administrative supplement to R01CA246589 is to provide support, mentorship, and training to Glynnis McDonnell, PhD, as a postdoctoral fellow under the mentorship of Kenneth Tercyak and Beth Peshkin at Georgetown University's Lombardi Comprehensive Cancer Center, Cancer Prevention and Control Program. Over a two-year period, this fellowship will promote the applicant's/fellow's growth as an independent behavioral science researcher in the area of cancer control and prevention with a focus on family communication through six major activities: 1) mentored research experiences with the parent study team; 2) advanced training in mixed-methods research (qualitative-quantitative analysis of behavioral data) to advance outcomes of genetic counseling; 3) participation in didactic opportunities through Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, and the Cancer Prevention and Control Program; 4) attendance at national scientific meetings (virtual, or in-person when resumed); 5) preparation of manuscripts for publication in peer-reviewed journals, and; 6) developing and submitting an NIH/NCI research career development award application to extend the learning. This supplement opportunity will also allow the applicant to enhance her competencies in behavioral research theory and methodology through exposure to the parent study’s RCT research implementation, and help develop expertise in the content area of genetic counseling interventions for families at high breast cancer risk. With interests in psychosocial kinship factors influencing health behaviors across the lifespan, the applicant aims to: 1) characterize mothers’ perspectives about the social and psychological advantages and disadvantages of communicating with children about BRCA genetic testing, inherited cancer risks, and cancer prevention, and 2) examine associations among maternal BRCA carrier status and cancer history with mother-child distress, as well as sociodemographic moderators of distress. Given well-established disparities in cancer outcomes, and the potential for genetics to transform clinical and public health approaches to cancer risk identification and management, the proposed training plan is significant because it will inform Healthy People 2030 goals surrounding genetic counseling for hereditary breast cancer, increasing the health-related quality of life of cancer survivors, and doing so equitably across diverse populations. After training, the applicant will be positioned to lead high-impact research in this area.