Improving Genetic Counseling for BRCA+ Mothers

改善 BRCA 母亲的遗传咨询

• 批准号: 10292670
• 负责人: BETH N PESHKIN
• 金额: $ 6.08万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-02 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292670
• 关键词: Academic Medical Centers; Administrative Supplement; Area; Behavioral; Behavioral Research; Behavioral Sciences; Breast Cancer Risk Factor; Cancer Control; Cancer Control Research; Cancer Survivor; Child; Clinical; Communication; Competence; Comprehensive Cancer Center; Data; Disadvantaged; Distress; Doctor of Philosophy; Exposure to; Family; Fellowship; Genetic; Genetic Counseling; Goals; Growth; Health; Health behavior; Hereditary Breast Carcinoma; Inherited; Intervention; Journals; K-Series Research Career Programs; Lead; Learning; Longevity; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Methodology; Mothers; Outcome; Parents; Peer Review; Personal Satisfaction; Persons; Population Heterogeneity; Positioning Attribute; Postdoctoral Fellow; Preparation; Public Health; Publications; Recording of previous events; Research; Research Methodology; Research Personnel; Testing; Training; United States National Institutes of Health; Universities; behavioral outcome; behavioral study; cancer health disparity; cancer prevention; cancer risk; carrier status; experience; genetic testing; health related quality of life; improved; interest; meetings; professor; programs; psychologic; psychosocial; social; sociodemographics; theories; virtual

Project Abstract The purpose of this NIH/NCI administrative supplement to R01CA246589 is to provide support, mentorship, and training to Glynnis McDonnell, PhD, as a postdoctoral fellow under the mentorship of Kenneth Tercyak and Beth Peshkin at Georgetown University's Lombardi Comprehensive Cancer Center, Cancer Prevention and Control Program. Over a two-year period, this fellowship will promote the applicant's/fellow's growth as an independent behavioral science researcher in the area of cancer control and prevention with a focus on family communication through six major activities: 1) mentored research experiences with the parent study team; 2) advanced training in mixed-methods research (qualitative-quantitative analysis of behavioral data) to advance outcomes of genetic counseling; 3) participation in didactic opportunities through Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, and the Cancer Prevention and Control Program; 4) attendance at national scientific meetings (virtual, or in-person when resumed); 5) preparation of manuscripts for publication in peer-reviewed journals, and; 6) developing and submitting an NIH/NCI research career development award application to extend the learning. This supplement opportunity will also allow the applicant to enhance her competencies in behavioral research theory and methodology through exposure to the parent study’s RCT research implementation, and help develop expertise in the content area of genetic counseling interventions for families at high breast cancer risk. With interests in psychosocial kinship factors influencing health behaviors across the lifespan, the applicant aims to: 1) characterize mothers’ perspectives about the social and psychological advantages and disadvantages of communicating with children about BRCA genetic testing, inherited cancer risks, and cancer prevention, and 2) examine associations among maternal BRCA carrier status and cancer history with mother-child distress, as well as sociodemographic moderators of distress. Given well-established disparities in cancer outcomes, and the potential for genetics to transform clinical and public health approaches to cancer risk identification and management, the proposed training plan is significant because it will inform Healthy People 2030 goals surrounding genetic counseling for hereditary breast cancer, increasing the health-related quality of life of cancer survivors, and doing so equitably across diverse populations. After training, the applicant will be positioned to lead high-impact research in this area.

项目摘要 R01CA246589的NIH/NCI行政补充的目的是提供支持，Mentalship， 并在肯尼斯·泰西克（Kenneth Tercyak）的指导下训练了Glynnis McDonnell博士，作为博士后研究员 乔治敦大学伦巴第综合癌症中心的贝丝·佩什金（Beth Peshkin），癌症预防和 控制程序。在两年的时间内，该奖学金将促进申请人/同伴的成长 独立的行为科学研究人员在癌症控制和预防领域，重点是家庭 通过六项主要活动进行沟通：1）与家长学习团队一起指导研究经验； 2） 混合方法研究的高级培训（对行为数据的定性定量分析） 遗传咨询的结果； 3）通过乔治敦大学参加教学机会 医疗中心，伦巴第综合癌症中心以及癌症预防和控制计划； 4） 参加国家科学会议（恢复时虚拟或面对面）； 5）手稿的准备 用于在同行评审期刊上出版； 6）开发和提交NIH/NCI研究生涯 开发奖的应用程序扩展学习。这种补充机会也将允许申请 通过接触父母，以增强她在行为研究理论和方法论中的能力 研究的RCT研究实施，并帮助发展遗传咨询内容领域的专业知识 对高乳腺癌风险的家庭干预措施。对影响的社会心理亲属因素的兴趣 整个生命周期的健康行为，申请人的目的是：1）表征母亲对 与儿童交流有关BRCA遗传的社会和心理优势和缺点 测试，遗传的癌症风险和预防癌症，以及2）孕产妇BRCA的检查关联 带有母子困扰的载体状况和癌症历史，以及社会人口统计学主持人 困扰。鉴于癌症结局的公认差异，以及遗传学转化的潜力 临床和公共卫生方法用于癌症风险识别和管理，拟议的培训计划 之所以重要，是因为它将为健康的人2030目标提供围绕遗传咨询的目标的目标 乳腺癌，增加与健康相关的癌症生存质量，并在整个 多样化的人口。训练后，申请人将被定位为在该领域进行高影响研究。