Pilot and Exploratory Studies Core

7.项目概要- PESC UM-OAIC试点和探索性研究核心（PESC）的总体目标是提供关键的初始资金 进行试点和探索性研究，与中心的总体目标一致，即建立在 运动和康复的科学和治疗应用：1）提高我们对 针对特定损伤的运动、基于活动的和康复干预机制 影响多个身体系统的功能表现; 2）开发和测试干预措施， 在老年人中恢复功能并尽量减少急性和慢性严重疾病造成的残疾。到 为实现这些目标，我们提出：1）征集和选拔高素质的创新试点和探索性人才， 与UM-OAIC总体目标一致的研究（PES）; 2）支持这些研究的实施 通过利用PESC和UM-OAIC资源，创新和有前途的PES。这些资源 结构，以支持成功的设计和实施PES，包括：研究设计工作室 提供具体的方法专门知识;项目执行支助小组确保及时和 有效启动研究项目;多学科研究工作组提供指导 并指导和协助调查人员进行项目，报告结果，并发展未来 调查事务所试点研究获奖者将进一步利用UM-OAIC资源核心的资源 沿着位于巴尔的摩的马里兰州大学的联合项目和中心， 马里兰州，并通过与其他OAIC的合作在全国范围内开展工作。PES将通过严格的 由研究教育咨询小组领导的同行评审过程，评审员选自外部 顾问委员会成员、其他OAIC的领导人以及核心领导执行委员会成员。输入 还将征求社区咨询委员会的意见，以确保项目与老年人相关 以及来自巴尔的摩和马里兰州不同社区的护理人员。三个创新 项目将在竞争性更新的第一年被选中获得资助，由来自 流行病学和公共卫生，骨科，肺和重症监护医学部门。 这些项目将调查：1）抑郁和疼痛对膝关节功能结果的交叉点 骨关节炎，利用骨关节炎倡议的数据; 2）细胞力学作为生物学机制 年龄，使用平移方法检查微管结构和膀胱镜硬度作为 临床前和人体模型中的生物学年龄;以及3）远程医疗的试点级随机对照试验 老年重症监护室幸存者的功能结果，再住院， 门诊保留。从这些试点和探索性研究中获得的结果将提供关键的 初步数据，以支持赠款申请校外资助更大，更明确的研究- 发起的研究。

7. Project Summary- PESC The overall goal of the UM-OAIC Pilot and Exploratory Studies Core (PESC) is to provide critical initial funding for pilot and exploratory studies that are consistent with the Center’s overall goal, which is to build on the scientific and therapeutic applications of exercise and rehabilitation by: 1) advancing our understanding of the mechanisms by which exercise, activity-based, and rehabilitation interventions directed at specific impairments affect multiple body systems underlying functional performance; and 2) developing and testing interventions to restore function and minimize disability from acute and chronic serious diseases in older adults. To accomplish these goals, we propose: 1) To solicit and select high-quality innovative pilot and exploratory studies (PES) that are consistent with the overall UM-OAIC goal; and 2) support the implementation of these innovative and promising PES through the utilization of PESC and UM-OAIC resources. These resources are structured to support the successful design and implementation of PES and include: Research Design Studios to provide specific methodological expertise; Project Implementation Support Groups to ensure prompt and efficient initiation of research projects; and multidisciplinary Research Working Groups to provide mentoring and guide and assist investigators in conducting their projects, reporting results, and developing future investigations. Pilot study awardees will further leverage the resources from the UM-OAIC Resource Cores along with allied programs and centers at the University of Maryland, Baltimore, the larger University System of Maryland, and nationally through collaboration with other OAICs. PES will be selected through a rigorous peer review process led by the Research Education Advisory Panel, with reviewers selected from the External Advisory Board, leaders from other OAICs, and a member of the Core Leadership Executive Committee. Input will also be solicited from the Community Advisory Board to ensure that projects are relevant in older adults and their caregivers from diverse communities in Baltimore and the State of Maryland. Three innovative projects will be selected for funding in the first year of this competitive renewal, led by PIs from the Departments of Epidemiology and Public Health, Orthopedics, and Pulmonary and Critical Care Medicine. These projects will investigate: 1) The intersection of depression and pain on functional outcomes in knee osteoarthritis, utilizing data from the Osteoarthritis Initiative; 2) cell mechanics as a mechanism of biological age, using translational methods to examine microtubular structure and cystokeletal stiffness as markers of biological age in pre-clinical and human models; and 3) a pilot-level randomized controlled trial of telemedicine and telerehabilitation in older Intensive Care Unit survivors on functional outcomes, rehospitalization, and ambulatory clinic retention. The results obtained from these pilot and exploratory studies will provide key preliminary data to support grant applications for extramural funding for larger, more definitive investigator- initiated studies.