Chronic Renal Dysfunction and Ischemic Brain Disease

超出提供的空间。与普通人群相比，认知障碍的部分原因是血管疾病加速。虽然大多数报告都集中在与evxatsrcauolradrinadrisileyasheighonracterseborfovmaosrctauliatyr相关的危险因素和结果上，但对其他患者的定义不明确，可能会显著导致他们的明显认知障碍。尽管有少数研究报道肾功能不全患者发生中风的风险增加，但与临床和亚临床中风相关的危险因素和结果尚未确定。我们假设，通过促进加速血管疾病的因素，肾功能障碍患者患临床和亚临床中风的风险更高，这导致肾脏疾病患者认知功能障碍和痴呆的高患病率。本研究的总体目标是确定肾功能障碍与临床和亚临床卒中风险之间的关系，确定特定的卒中危险因素，并量化慢性肾功能不全(CRI)和终末期肾病(ESRD)患者的相关认知功能障碍。拟议的研究将涉及一系列观察性研究。首先，将利用多中心前瞻性队列研究的数据，评估肾功能障碍与临床卒中之间的联系，并确定CRI和ESRD患者中的卒中危险因素。接下来，使用作为这些研究的一部分收集的MRI和神经精神病学数据，我们将确定CRI患者是否有更高的亚临床脑梗塞风险，以及这是否导致更高的痴呆症风险。最后，将对血液透析患者进行MRI成像和认知功能纵向测量，以确定亚临床脑梗塞的危险因素，并确定这些脑梗塞与认知功能下降之间的关系。这些研究通过阐明中风的相关危险因素和不良后果，可能导致开发新的策略来诊断和预防肾病患者的缺血性脑病，最终改善这些患者的预后。表演网站========================================Section End===========================================

EXCEED THE SPACE PROVIDED. and cognitive impairment compared to the general population, in part due to accelerated vascular disease. Although the majority of reports have focused on risk factors and outcomes associated with cPartdieiancts dwisiethasre,nathl edyismfupnactioonf ascucfefelerrafrtoemd evxatsrcauolradrinadrisileyasheighonracterseborfovmaosrctauliatyr aonudtcomaerksedamfuonncgtionthaelse patients are not well defined and may contribute significantly to their marked cognitive impairment. Although a few studies have reported an increased risk of stroke among patients with renal dysfunction, risk factors and outcomes associated with clinical and subclinical stroke have not been identified. We hypothesize that patients with renal dysfunction, through factors which promote accelerated vascular disease, are at a higher risk of clinical and subclinical stroke, which contributes to a high prevalence of cognitive dysfunction and dementia in patients with renal disease. The overall objectives of this study are to determine the association between renal dysfunction and risk of clinical and subclinical stroke, identify specific stroke risk factors, and quantify the associated cognitive dysfunction among patients with chronic renal insufficiency (CRI) and end-stage renal disease (ESRD). The proposed research will involve a series of observational studies. First, the association between renal dysfunction and clinical stroke will be estimated and stroke risk factors among CRI and ESRD pts will be identified, using data from multicenter prospective cohort studies. Next, using MRI and neuropsychiatric data collected as part of one these studies, we will determine whether patients with CRI are at higher risk for subclinical brain infarcts, and whether this contributes to a higher risk of dementia. Finally, MRI imaging and longitudinal measurements of cognitive function will be performed on hemodialysis patients, to determine risk factors for subclinical brain infarcts and define the relationship between these infarcts and cognitive decline. These studies, by clarifying associated risk factors and adverse outcomes of stroke, could result in the development of new strategies to diagnose and prevent ischemic brain disease in patients with renal disease, ultimately leading to an improved prognosis for these patients. PERFORMANCE SITE ========================================Section End===========================================