CKD AND BRAIN DISEASE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。美国有800万慢性肾病（CKD）患者，他们患有明显的功能障碍，患痴呆症和认知功能障碍的风险极高。虽然CKD也与血管疾病的发生率增加有关，但脑缺血在导致这种认知障碍中的作用尚不清楚。在没有肾脏疾病的个体中，通过核医学技术检测到的脑血流量（CBF）受损最近已被确定为认知障碍和认知下降的强相关性，并且与流行的心血管危险因素相关。然而，脑灌注不足和认知功能障碍之间的关系尚未在CKD中进行评估。我们建议使用单光子发射计算机断层扫描（SPECT）测量中晚期慢性肾脏病老年人（65岁）的脑血流量。我们将通过与该部门的Shari Waldstein博士合作，将这些测量结果与先前收集的无肾脏疾病的年龄相似的高血压患者的CBF数据进行比较，以检查肾功能和脑灌注不足之间的关联。心理学和医学。此外，我们将联合收割机将这些CBF测量与脑MRI和认知功能数据相结合，这些数据将作为NIH资助的研究职业发展奖的一部分在CKD研究人群中收集，并将身体功能测量作为UMB Pepper中心研究发展核心试点补助金的一部分收集。我们将研究CKD患者的脑灌注、神经认知和身体功能以及MRI定义的缺血性脑损伤之间的相互关系。这些分析是确定CKD患者保留脑功能的机会的第一步。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are 8 million individuals in the US with Chronic Kidney Disease (CKD), who suffer from marked functional impairment and an extraordinarily high risk of dementia and cognitive dysfunction. Although CKD is also associated with an increased rate of vascular disease, the role of brain ischemia in contributing to this cognitive impairment is unknown. In individuals without kidney disease, impaired cerebral blood flow (CBF) - as detected by nuclear medicine techniques - has been recently identified as a strong correlate of cognitive impairment and cognitive decline, and is associated with prevalent cardiovascular risk factors. However, the relationship between cerebral hypoperfusion and cognitive dysfunction has not been assessed in CKD. We are proposing to measure cerebral blood flow in a population of older adults (age65) with moderate-advanced chronic kidney disease using single-photon emission computed tomography (SPECT). We will examine the association between renal function and cerebral hypoperfusion by comparing these measures with previously collected CBF data in age-similar hypertensives without kidney disease, through collaboration with Dr. Shari Waldstein of the Depts. of Psychology and Medicine. Additionally, we will combine these CBF measurements with brain MRI and cognitive function data to be collected in the CKD study population as part of an NIH-funded Research Career Development Award, and measures of physical function to be collected as part of a UMB Pepper Center Research Development Core Pilot Grant. We will examine the inter-relationship among cerebral perfusion, neurocognitive and physical function, and MRI-defined ischemic brain damage in CKD. These analyses are the first steps towards identifying opportunities to preserve brain function in individuals with CKD.