University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)

7. 项目概要：总体 UM-OAIC 的主题是“赋能”，定义为恢复那些有损伤和残疾的人的功能。 预防或延迟那些已经残疾的人的进一步进展。的总体使命 UM-OAIC 旨在制定、实施和评估旨在改善和 恢复患有残疾的老年人的活动能力和功能独立性。这将是 通过以下方式实现： 1) 加深我们对运动和基于活动的机制的理解 针对特定损伤的多模式康复干预会影响多个身体系统； 2） 制定和测试干预措施，以恢复功能并最大限度地减少急性致残事件后的残疾 并预防与严重慢性疾病相关的衰退； 3）培训下一代研究人员 谁将进一步了解衰老过程并制定有助于促进健康和健康的干预措施 患有残疾疾病的老年人的独立性。 老年人发生的功能障碍和残疾是由急性事件引起的，例如 中风、心脏病和髋部骨折，或反映慢性疾病的进展。这条途径如何 疾病导致残疾，即残疾，已被广泛讨论。 UM-OAIC 的使命 残疾知识，重点关注残障人士的功能恢复并预防 或延迟那些已经残疾的人的进一步进展，即启用。 UM-OAIC 的目标是： 1) 进行研究，检查潜在的机制 与急性致残事件（例如中风、髋部骨折）和流行的慢性事件相关的功能障碍 老年人的疾病（例如心力衰竭、癌症）。 2）设计新颖、锻炼活动为主 产生临床相关结果并研究潜在机制的康复干预措施 他们。 3) 将 UM-OAIC 临床实验室和其他地方开发的干预措施转化为实施 以及在家庭和社区环境中进行严格的评估。 4) 支持试点和探索性研究，UM-OAIC 符合 UM-OAIC 的学者研究、开发项目和外部资助项目 主题。 5) 支持多学科青年教师和学者的发展 从事老年人研究方面具有专业知识的独立学术科学家和领导者的职业生涯 通过从实验室到临床到社区的导师式、教学式和体验式培训来消除疾病 转化研究。

7. Project Summary: Overall The theme of the UM-OAIC is enablement defined as the restoration of function in those with impairments and the prevention or delay of further progression in those who are already disabled. The overarching mission of the UM-OAIC is to develop, implement, and evaluate rehabilitative strategies that are designed to improve and restore mobility and functional independence in older persons with disabling conditions. This will be accomplished by 1) advancing our understanding of the mechanisms by which exercise and activity-based and multi-modal rehabilitation interventions directed at specific impairments affect multiple body systems; 2) developing and testing interventions to restore function and minimize disability following acute disabling events and to prevent declines related to serious chronic diseases; and 3) training the next generation of investigators who will further the understanding of the aging process and develop interventions that help promote health and independence in older adults with disabling medical conditions. The functional impairments and disabilities that occur in older people emanate from acute events, such as stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. This pathway of how disease leads to disability, i.e., disablement, has been discussed extensively. The UM-OAIC’s mission builds knowledge of disablement and focuses on the restoration of function in those with impairments and to prevent or delay further progression in those already disabled, i.e. enablement. The aims of the UM-OAIC are to: 1) Conduct research that examines the mechanisms underlying the functional impairments associated with acute disabling events (e.g., stroke, hip fracture) and prevalent chronic diseases (e.g., heart failure, cancer) in older people. 2) Design novel, exercise and activity-based and rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying them. 3) Translate interventions developed in UM-OAIC clinical laboratories and elsewhere for implementation and rigorous evaluation in home and community settings. 4) Support pilot and exploratory studies, UM-OAIC Scholar research, development projects, and externally funded projects that are consistent with the UM-OAIC theme. 5) Support the development of junior faculty and Scholars from multiple disciplines as they pursue careers as independent, academic scientists and leaders with expertise in the study of older persons with disabling diseases through mentor-based, didactic and experiential training in bench-to-bedside-to-community translational research.