University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)

7.项目总结：总体 UM-OAIC的主题是赋能，其定义为恢复那些有残疾和 阻止或延缓那些已经残疾的人的进一步进展。的首要任务是 UM-OAIC是开发、实施和评估旨在改善和 恢复患有残疾的老年人的行动能力和功能独立。这将是 通过1)促进我们对运动和以活动为基础和 针对特定损伤的多模式康复干预影响多个身体系统；2) 制定和测试干预措施，以恢复功能并最大限度地减少急性致残事件后的残疾 防止与严重慢性病有关的下降；以及3)培训下一代调查人员 世卫组织将加深对老龄化过程的了解，并制定有助于促进健康和 患有致残疾病的老年人的独立性。 老年人发生的功能障碍和残疾是由急性事件引起的，例如 中风、心脏病发作和髋部骨折，或反映慢性病的进展。这条道路是如何 疾病导致残疾，即残疾，已被广泛讨论。UM-OAIC的使命是建立 残障知识，重点是残障人士的功能恢复和预防 或者延迟那些已经被禁用的设备的进一步进展，即启用。 UM-OAIC的目标是：1)进行研究，检查潜在的机制 与急性致残事件(如中风、髋部骨折)和普遍存在的慢性疾病相关的功能障碍 老年人的疾病(如心力衰竭、癌症)。2)设计新颖、锻炼和以活动为基础的 产生临床相关结果并研究潜在机制的康复干预措施 他们。3)翻译在UM-OAIC临床实验室和其他地方制定的干预措施，以便实施 在家庭和社区环境中进行严格的评估。4)支持试点和探索性研究，UM-OAIC 符合UM-OAIC的学者研究、开发项目和外部资助项目 主题。5)支持初级教师和多学科学者的发展 作为独立的、学术科学家和在老年人研究方面具有专门知识的领导人的职业生涯 通过以导师为基础、指导性和体验式的从板凳到床边到社区的培训来消除疾病 翻译研究。

7. Project Summary: Overall The theme of the UM-OAIC is enablement defined as the restoration of function in those with impairments and the prevention or delay of further progression in those who are already disabled. The overarching mission of the UM-OAIC is to develop, implement, and evaluate rehabilitative strategies that are designed to improve and restore mobility and functional independence in older persons with disabling conditions. This will be accomplished by 1) advancing our understanding of the mechanisms by which exercise and activity-based and multi-modal rehabilitation interventions directed at specific impairments affect multiple body systems; 2) developing and testing interventions to restore function and minimize disability following acute disabling events and to prevent declines related to serious chronic diseases; and 3) training the next generation of investigators who will further the understanding of the aging process and develop interventions that help promote health and independence in older adults with disabling medical conditions. The functional impairments and disabilities that occur in older people emanate from acute events, such as stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. This pathway of how disease leads to disability, i.e., disablement, has been discussed extensively. The UM-OAIC’s mission builds knowledge of disablement and focuses on the restoration of function in those with impairments and to prevent or delay further progression in those already disabled, i.e. enablement. The aims of the UM-OAIC are to: 1) Conduct research that examines the mechanisms underlying the functional impairments associated with acute disabling events (e.g., stroke, hip fracture) and prevalent chronic diseases (e.g., heart failure, cancer) in older people. 2) Design novel, exercise and activity-based and rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying them. 3) Translate interventions developed in UM-OAIC clinical laboratories and elsewhere for implementation and rigorous evaluation in home and community settings. 4) Support pilot and exploratory studies, UM-OAIC Scholar research, development projects, and externally funded projects that are consistent with the UM-OAIC theme. 5) Support the development of junior faculty and Scholars from multiple disciplines as they pursue careers as independent, academic scientists and leaders with expertise in the study of older persons with disabling diseases through mentor-based, didactic and experiential training in bench-to-bedside-to-community translational research.