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University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)

马里兰大学克劳德·D·佩珀美国老年人独立中心 (OAIC)

基本信息

批准号：
10670247
负责人：
Leslie I. Katzel
金额：
$ 119.68万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670247
关键词：
Academy Acute Aerobic Affect Aging American Animal Model Area Biometry Capsicum Caring Cessation of life Chronic Disease Clinic Clinical Collaborations Communities Degenerative polyarthritis Development Disabled Persons Discipline Disease Pathway Elderly Engineering Enrollment Environment Evaluation Event Exercise Faculty Fatigue Funding Future Geriatrics Health Promotion Heart failure Hip Fractures Home Impaired cognition Impairment Informatics Institutionalization Intervention Knowledge Laboratories Leadership Life Expectancy Maintenance Malignant Neoplasms Maryland Medical Mentors Mission Myocardial Infarction Neuronal Plasticity Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Parkinson Disease Physiological Physiology Prevention Process Rehabilitation therapy Research Research Personnel Research Training Resources Risk Robotics SARS-CoV-2 infection Scientist Services Stroke Technology Testing Training Translating Translational Research Treatment Efficacy Underrepresented Minority Universities Vascular Diseases Work aged bench to bedside body system career clinical center clinically relevant community setting design disability disabling disease education research efficacy testing frailty functional disability functional improvement functional independence functional restoration improved industry partner innovation multimodality new technology next generation novel novel strategies operation pre-clinical prevent programs public health priorities rehabilitation research rehabilitation science rehabilitation technology restoration sarcopenia translational pipeline

项目摘要

7. Project Summary: Overall The theme of the UM-OAIC is enablement defined as the restoration of function in those with impairments and the prevention or delay of further progression in those who are already disabled. The overarching mission of the UM-OAIC is to develop, implement, and evaluate rehabilitative strategies that are designed to improve and restore mobility and functional independence in older persons with disabling conditions. This will be accomplished by 1) advancing our understanding of the mechanisms by which exercise and activity-based and multi-modal rehabilitation interventions directed at specific impairments affect multiple body systems; 2) developing and testing interventions to restore function and minimize disability following acute disabling events and to prevent declines related to serious chronic diseases; and 3) training the next generation of investigators who will further the understanding of the aging process and develop interventions that help promote health and independence in older adults with disabling medical conditions. The functional impairments and disabilities that occur in older people emanate from acute events, such as stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. This pathway of how disease leads to disability, i.e., disablement, has been discussed extensively. The UM-OAIC’s mission builds knowledge of disablement and focuses on the restoration of function in those with impairments and to prevent or delay further progression in those already disabled, i.e. enablement. The aims of the UM-OAIC are to: 1) Conduct research that examines the mechanisms underlying the functional impairments associated with acute disabling events (e.g., stroke, hip fracture) and prevalent chronic diseases (e.g., heart failure, cancer) in older people. 2) Design novel, exercise and activity-based and rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying them. 3) Translate interventions developed in UM-OAIC clinical laboratories and elsewhere for implementation and rigorous evaluation in home and community settings. 4) Support pilot and exploratory studies, UM-OAIC Scholar research, development projects, and externally funded projects that are consistent with the UM-OAIC theme. 5) Support the development of junior faculty and Scholars from multiple disciplines as they pursue careers as independent, academic scientists and leaders with expertise in the study of older persons with disabling diseases through mentor-based, didactic and experiential training in bench-to-bedside-to-community translational research.

7. 项目总结：