Effects of abnormal early experience on IT circuitry

早期异常经历对 IT 电路的影响

• 批准号: 10296415
• 负责人: MARGARET S LIVINGSTONE
• 金额: $ 203.91万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10296415
• 关键词: Acute; Adolescent; Adult; Age; Amblyopia; Animal Testing; Animals; Area; Augmented Reality; Behavior; Behavioral; Birth; Blinking; Body part; Brain; Categories; Cells; Chronic; Cognitive; Color; Complex; Coupled; Development; Devices; Electrophysiology (science); Equilibrium; Eye; Eye Movements; Face; Felis catus; Functional Magnetic Resonance Imaging; Goals; Goggles; Helmet; Histocytochemistry; Human; Image; Individual; Infant; Left; Life Experience; Light; Lighting; Macaca; Microcomputers; Monkeys; Neurological observations; Neurons; Ocular Dominance; Optics; Pattern; Positioning Attribute; Primates; Reading; Research; Sensory; Shapes; Site; Social Behavior; Spottings; Strabismus; System; Temporal Lobe; Testing; Tetrodotoxin; Text; Vision; Visual; Visual Pathways; White Spots; Work; contrast imaging; cytochrome c oxidase; deprivation; early experience; experience; extrastriate visual cortex; inferotemporal cortex; lens; light weight; liquid crystal; luminance; monocular; neural network; novel; object perception; object recognition; orientation selectivity; relating to nervous system; skills; statistics; visual information; visual process

Project Summary The goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific manipulations of early visual experience. In adult humans and monkeys discrete regions of the temporal lobe are specialized for processing particular object categories, such as faces, text, bodies, or places. These domains underlie complex object recognition. Visual experience of these categories is both necessary and sufficient to produce domains, and the goal is to explore how specific abnormal early visual experience changes neuronal selectivity.

项目摘要 这项研究的目的是通过特定的方法来探测颞下皮层的物体识别回路。 早期视觉经验的操纵。在成年人和猴子的颞叶离散区域 专门用于处理特定的对象类别，如面部、文本、身体或位置。These domains 是复杂物体识别的基础。这些类别的视觉体验是必要的，也是足够的， 产生域，目标是探索特定的异常早期视觉体验如何改变神经元 选择性