The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank

环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响

• 批准号: 10295994
• 负责人: Audrey Jane Gaskins
• 金额: $ 32.06万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10295994
• 关键词: Address; Adverse effects; Affect; Air Pollution; Antral; Assisted Reproductive Technology; Autologous; Biological; Birth Rate; Carbon; Carbon Monoxide; China; Clinic; Clinical; Couples; Development; Embryo; Embryo Transfer; Embryonic Development; Endometrial; Endometrium; Environment; Environmental Exposure; Europe; Event; Exposure to; Female; Fertility; Fertility Rates; Fertilization; Germ Cells; Gestational Age; Health; Human; Infertility; Knowledge; Link; Live Birth; Mediating; Medical Assistance; Modeling; Motor Vehicles; Nitrogen Dioxide; Nitrogen Oxides; Oocyte Donation; Oocytes; Oogenesis; Outcome; Ovarian Stimulations; Ozone; Paternal Exposure; Patients; Physicians; Population; Pregnancy; Pregnancy Outcome; Pregnancy loss; Premature Birth; Privatization; Probability; Reproduction; Research; Resources; Risk; Sampling; Sex Ratio; Spermatogenesis; Sulfur Dioxide; Time; United States; Uterus; Woman; ambient air pollution; blastocyst; coarse particles; cohort; cost effective; embryo cryopreservation; embryo quality; epidemiology study; global health; human model; implantation; male; men; novel; oocyte quality; ovarian reserve; pollutant; reproductive; reproductive outcome; spatiotemporal; sperm cell; traffic-related air pollution

PROJECT SUMMARY/ABSTRACT Air pollution, particularly due to motor vehicles, is a ubiquitous exposure and a significant global health threat, responsible for many adverse health outcomes. Emerging evidence also suggests that traffic-related air pollution may be related to lower fecundity and fertility among couples attempting to conceive both with and without medical assistance. However, the specific pollutants, exposure windows, and biological mechanisms underlying these associations remain understudied. To address these important knowledge gaps, this proposal will use a novel and emerging model of human fertility- vitrified donor oocyte assisted reproductive technology (ART)- to evaluate how air pollution influences human reproduction using a large cohort of oocyte donors and oocyte recipient couples attending a private fertility clinic in Atlanta, GA (2008- 2019). Residential exposure to traffic-related air pollution will be derived during multiple biologically relevant windows of exposure in the female donor, female recipient, and male recipient partner using fine-scale spatiotemporal models of nitrogen oxides, carbon monoxide, fine particular matter (PM), and elemental carbon as well as sulfur dioxide, ozone, nitrogen dioxide, PM10 , and PM constituents. Vitrified donor oocyte ART represents an ideal population to investigate the mechanisms underlying any associations between air pollution and fertility as exposures to the oocyte and uterine environment are uncorrelated in time or space and exposures to the oocyte and sperm are uncorrelated during the relevant exposure windows for fertilization and embryo development. Furthermore, by studying patients undergoing ART, it is possible to determine exact periods of air pollution exposure and directly observe early reproductive outcomes, such as fertilization and early embryo development that would never be observed in couples conceiving without assistance. This research will determine the independent effects of air pollution exposure during oogenesis and spermatogenesis on fertilization and early embryo development, the independent effects of air pollution on pregnancy outcomes as mediated through the oocyte and the endometrium, and the extent to which air pollution affects fertility potential in young, healthy women. Findings from this proposal will have major

项目摘要/摘要 空气污染，尤其是由于汽车，是无处不在的暴露和全球巨大的健康状况 威胁，负责许多不良健康结果。新兴证据也表明与交通有关 空气污染可能与试图怀孕的夫妇之间的繁殖力和生育能力降低有关 没有医疗援助。但是，特定的污染物，曝光窗和生物学 这些关联的基础机制仍在研究。解决这些重要知识 差距，该提案将使用人类生育能力的新颖而新兴的玻璃体供体卵母细胞的辅助模型 生殖技术（ART） - 评估空气污染如何使用大型 在亚特兰大，乔治亚州私人生育诊所的卵母细胞供体和卵母细胞的队列夫妇（2008-- 2019）。在多个生物学相关的过程中，将引发与交通相关的空气污染的住宅暴露 女性捐助者，女性接受者和男性接收者伴侣使用细尺度的曝光窗口 氮氧化物，一氧化碳，精细物质（PM）和元素的时空模型 碳以及二氧化硫，臭氧，二氧化氮，PM10和PM成分。玻璃化供体卵母细胞 艺术代表了调查空气之间任何关联机制的理想人群 随着卵母细胞和子宫环境暴露的污染和生育能力在时间或空间中不相关 在相关的曝光窗口中，对卵母细胞和精子的暴露是不相关的 受精和胚胎发育。此外，通过研究接受ART的患者，可以 确定空气污染的确切周期，并直接观察到早期生殖结果，例如 受精和早期胚胎发育，在没有受孕的夫妇中永远不会观察到 协助。这项研究将确定卵子发生过程中空气污染的独立影响 以及精子发生对施肥和早期胚胎发育，空气污染的独立影响 关于通过卵母细胞和子宫内膜介导的怀孕结局以及空气的程度 污染会影响年轻，健康女性的生育潜力。该提议的发现将有很大的