Extreme heat events and fertility: a national study
极端高温事件与生育率:一项全国性研究
基本信息
- 批准号:10613567
- 负责人:
- 金额:$ 23.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:Adverse effectsAffectAgeAnimalsAntralArtificial InseminationAssisted Reproductive TechnologyBirthBirth RateCharacteristicsClinicalCommunitiesCompetenceCountryCouplesDataData SetDatabasesDevelopmentEmbryoEmbryo TransferEmbryonic DevelopmentEndometrialEthnic OriginEventExposure toFemaleFertilityFirst BirthsFrequenciesFutureGoalsGrowthHealthHeat Stress DisordersHeat WavesHormonesHumanHumidityImpairmentIndividualInduced HyperthermiaInfertilityInterventionLinkLiteratureLive BirthMammalsMaternal AgeMediatingMethodologyModelingOocytesOutcomeOvarian StimulationsOvaryOvulationPathway interactionsPatientsPhasePhysiciansPoliciesPopulation SizesPregnancyProbabilityProductionPublic HealthRaceRegulationReproductionResearchResolutionRoleSpermatogenesisStressStructureSurfaceSystemTemperatureTestingWeatherWomanclimate changeclimate zonecommunity-level factorcorpus luteumearly pregnancy lossembryo cryopreservationexperienceextreme heatextreme weatherfailure Implantationfolliculogenesisfollow-uphazardhealth warninghigh riskhuman modelimplantationmalemeteorological datamotherhoodoocyte maturationoocyte qualityoocyte retrievalovulation timereproductivereproductive outcomesperm cellsuccesstrend
项目摘要
PROJECT SUMMARY/ABSTRACT
The frequency and intensity of heatwaves and other extreme weather events is increasing rapidly owing to
climate change and is only projected to escalate in the coming decades. While the hazards of extreme heat on
human health are widely recognized, including adverse effects on pregnancy and birth outcomes, little is
known regarding ambient temperature and human fertility. Demographic studies suggest that hot weather
causes a significant decline in birth rates 8 to 10 months later, yet the drivers of this association are unclear.
The animal literature has also long documented a link between maternal hyperthermia induced by high
ambient temperatures and reduced fertility, largely mediated through effects on oocyte developmental
capacity; however, whether heat stress has a similar impact on follicular development in women is less clear.
The proposed research seeks to use a large existing database and robust methodological approaches to test
the overarching hypothesis that women exposed to extreme heat during folliculogenesis will have
compromised oocyte quality and embryo development, higher risk of implantation failure, and lower probability
of live birth. We also hypothesize that stronger effects will be observed following heat events of longer duration
and greater intensity and that effects will vary by temporal-, spatial-, and individual-level attributes. To test this
hypothesis, we will utilize data from over 2 million non-donor assisted reproductive technology (ART) cycles
initiated in the US from 1996 to 2016 that are collected as part of the National ART Surveillance System.
National weather data will be integrated using publicly available data from the High Resolution Land Data
Assimilation System– a national 1 km resolution dataset of near-surface temperature and humidity that spans
1981-2016. Women undergoing ART represent an ideal setting to investigate the hypothesis that extreme heat
affects fertility through adverse effects on the ovary as we can determine exact periods of extreme heat
exposure and directly observe early reproductive outcomes that would never be observed in couples
conceiving without assistance. By restricting our analysis to cycles using donor sperm and frozen embryo
transfers, we can also uniquely examine the effects of extreme heat exposure during folliculogenesis on ART
outcomes independent from heat exposures to the male partner and during the implantation window. Given the
parallel trends of rising temperatures and the increasing number of women delaying motherhood until 35 years
and older, understanding the effects of extreme heat on fertility is becoming increasingly important. Our
findings can greatly inform targeted regulations, policies, public health warning systems, and interventions with
the ultimate goal of reducing infertility and early pregnancy loss.
项目总结/摘要
热浪和其他极端天气事件的频率和强度正在迅速增加,
气候变化,预计在未来几十年内只会加剧。虽然极端高温的危害
人类健康,包括对怀孕和分娩结果的不利影响,
关于环境温度和人类生育能力的已知信息。人口统计学研究表明炎热的天气
导致出生率在8到10个月后显著下降,但这种关联的驱动因素尚不清楚。
长期以来,动物文献也记录了高血压引起的母体体温过高与高脂血症之间的联系。
环境温度和生育力降低,主要通过对卵母细胞发育的影响介导
然而,热应激是否对女性卵泡发育有类似的影响尚不清楚。
拟议的研究旨在利用现有的大型数据库和强大的方法来测试
最重要的假设是,在卵泡形成过程中暴露于极端高温的妇女将有
卵母细胞质量和胚胎发育受损,植入失败的风险较高,
活产。我们还假设,在持续时间较长的热事件后,将观察到更强的影响
和更大的强度,影响将因时间、空间和个人水平的属性而异。为了验证这一
假设,我们将利用来自200多万个非供体辅助生殖技术(ART)周期的数据
从1996年到2016年在美国发起,作为国家ART监测系统的一部分收集。
国家气象数据将使用高分辨率陆地数据的公开数据进行整合
同化系统-一个全国性的近地面温度和湿度的1公里分辨率数据集,
1981-2016.接受抗逆转录病毒治疗的妇女是研究极端高温
通过对卵巢的不利影响来影响生育能力,因为我们可以确定极端高温的确切时期
直接观察在夫妇中永远不会观察到的早期生殖结果
在没有帮助的情况下怀孕。通过将我们的分析限制在使用供体精子和冷冻胚胎的周期中,
转移,我们还可以独特地检查卵泡发生期间极端热暴露对ART的影响。
结果独立于男性伴侣和植入窗口期间的热暴露。鉴于
气温上升和越来越多的妇女推迟到35岁才生育的平行趋势
随着年龄的增长,了解极端高温对生育能力的影响变得越来越重要。我们
调查结果可以为有针对性的法规、政策、公共卫生预警系统和干预措施提供重要信息,
最终目标是减少不孕症和早孕丢失。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Audrey Jane Gaskins其他文献
NEIGHBORHOOD DEPRIVATION AND BLACK-WHITE DIFFERENCES IN IN VITRO FERTILIZATION OUTCOMES
- DOI:
10.1016/j.fertnstert.2022.08.258 - 发表时间:
2022-10-01 - 期刊:
- 影响因子:
- 作者:
Kerri E. Andre;Robert Hood;Audrey Jane Gaskins;Jennifer F. Kawwass;Rebecca Garland Almquist;Michael R. Kramer;Heather S. Hipp - 通讯作者:
Heather S. Hipp
BEHAVIORAL SYMPTOMS OF EATING DISORDERS AND RISK OF ENDOMETRIOSIS: A PROSPECTIVE COHORT STUDY
- DOI:
10.1016/j.fertnstert.2022.08.637 - 发表时间:
2022-10-01 - 期刊:
- 影响因子:
- 作者:
Sarah Thornburgh;Ariella R. Tabaac;Leslie V. Farland;Holly R. Harris;Kendrin R. Sonneville;Alison E. Field;Jorge E. Chavarro;Stacey A. Missmer;Audrey Jane Gaskins - 通讯作者:
Audrey Jane Gaskins
EFFECTS OF GREEN SPACE ON DONOR OOCYTE OUTCOMES
- DOI:
10.1016/j.fertnstert.2024.08.253 - 发表时间:
2024-10-01 - 期刊:
- 影响因子:
- 作者:
Kerri E. Andre;Robert Hood;Zsolt Peter Nagy;Daniel B. Shapiro;Jacqueline C. Lee;Audrey Jane Gaskins;Heather S. Hipp - 通讯作者:
Heather S. Hipp
IMPACT OF AMBIENT TEMPERATURE ON OVARIAN RESERVE AMONG WOMEN FROM A FERTILITY CLINIC
- DOI:
10.1016/j.fertnstert.2020.09.074 - 发表时间:
2020-09-01 - 期刊:
- 影响因子:
- 作者:
Audrey Jane Gaskins;Lidia Mínguez-Alarcón;Trang M. VoPham;Jaime E. Hart;Jorge E. Chavarro;Joel David Schwartz;Irene Souter;Russ Hauser;Francine Laden - 通讯作者:
Francine Laden
Audrey Jane Gaskins的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Audrey Jane Gaskins', 18)}}的其他基金
Extreme heat events and fertility: a national study
极端高温事件与生育率:一项全国性研究
- 批准号:
10429519 - 财政年份:2022
- 资助金额:
$ 23.51万 - 项目类别:
The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank
环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响
- 批准号:
10457007 - 财政年份:2021
- 资助金额:
$ 23.51万 - 项目类别:
The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank
环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响
- 批准号:
10624827 - 财政年份:2021
- 资助金额:
$ 23.51万 - 项目类别:
The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank
环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响
- 批准号:
10295994 - 财政年份:2021
- 资助金额:
$ 23.51万 - 项目类别:
Maternal Exposure to Air Pollution and Early Pregnancy Outcomes
母亲接触空气污染和早期妊娠结果
- 批准号:
10094056 - 财政年份:2019
- 资助金额:
$ 23.51万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 23.51万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 23.51万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 23.51万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 23.51万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 23.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 23.51万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 23.51万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 23.51万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 23.51万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 23.51万 - 项目类别:
Miscellaneous Programs