The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank

环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响

基本信息

  • 批准号:
    10624827
  • 负责人:
  • 金额:
    $ 24.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-01 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Air pollution, particularly due to motor vehicles, is a ubiquitous exposure and a significant global health threat, responsible for many adverse health outcomes. Emerging evidence also suggests that traffic-related air pollution may be related to lower fecundity and fertility among couples attempting to conceive both with and without medical assistance. However, the specific pollutants, exposure windows, and biological mechanisms underlying these associations remain understudied. To address these important knowledge gaps, this proposal will use a novel and emerging model of human fertility- vitrified donor oocyte assisted reproductive technology (ART)- to evaluate how air pollution influences human reproduction using a large cohort of oocyte donors and oocyte recipient couples attending a private fertility clinic in Atlanta, GA (2008- 2019). Residential exposure to traffic-related air pollution will be derived during multiple biologically relevant windows of exposure in the female donor, female recipient, and male recipient partner using fine-scale spatiotemporal models of nitrogen oxides, carbon monoxide, fine particular matter (PM), and elemental carbon as well as sulfur dioxide, ozone, nitrogen dioxide, PM10 , and PM constituents. Vitrified donor oocyte ART represents an ideal population to investigate the mechanisms underlying any associations between air pollution and fertility as exposures to the oocyte and uterine environment are uncorrelated in time or space and exposures to the oocyte and sperm are uncorrelated during the relevant exposure windows for fertilization and embryo development. Furthermore, by studying patients undergoing ART, it is possible to determine exact periods of air pollution exposure and directly observe early reproductive outcomes, such as fertilization and early embryo development that would never be observed in couples conceiving without assistance. This research will determine the independent effects of air pollution exposure during oogenesis and spermatogenesis on fertilization and early embryo development, the independent effects of air pollution on pregnancy outcomes as mediated through the oocyte and the endometrium, and the extent to which air pollution affects fertility potential in young, healthy women. Findings from this proposal will have major
项目总结/文摘

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Audrey Jane Gaskins其他文献

NEIGHBORHOOD DEPRIVATION AND BLACK-WHITE DIFFERENCES IN IN VITRO FERTILIZATION OUTCOMES
  • DOI:
    10.1016/j.fertnstert.2022.08.258
  • 发表时间:
    2022-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kerri E. Andre;Robert Hood;Audrey Jane Gaskins;Jennifer F. Kawwass;Rebecca Garland Almquist;Michael R. Kramer;Heather S. Hipp
  • 通讯作者:
    Heather S. Hipp
BEHAVIORAL SYMPTOMS OF EATING DISORDERS AND RISK OF ENDOMETRIOSIS: A PROSPECTIVE COHORT STUDY
  • DOI:
    10.1016/j.fertnstert.2022.08.637
  • 发表时间:
    2022-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sarah Thornburgh;Ariella R. Tabaac;Leslie V. Farland;Holly R. Harris;Kendrin R. Sonneville;Alison E. Field;Jorge E. Chavarro;Stacey A. Missmer;Audrey Jane Gaskins
  • 通讯作者:
    Audrey Jane Gaskins
EFFECTS OF GREEN SPACE ON DONOR OOCYTE OUTCOMES
  • DOI:
    10.1016/j.fertnstert.2024.08.253
  • 发表时间:
    2024-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kerri E. Andre;Robert Hood;Zsolt Peter Nagy;Daniel B. Shapiro;Jacqueline C. Lee;Audrey Jane Gaskins;Heather S. Hipp
  • 通讯作者:
    Heather S. Hipp
IMPACT OF AMBIENT TEMPERATURE ON OVARIAN RESERVE AMONG WOMEN FROM A FERTILITY CLINIC
  • DOI:
    10.1016/j.fertnstert.2020.09.074
  • 发表时间:
    2020-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Audrey Jane Gaskins;Lidia Mínguez-Alarcón;Trang M. VoPham;Jaime E. Hart;Jorge E. Chavarro;Joel David Schwartz;Irene Souter;Russ Hauser;Francine Laden
  • 通讯作者:
    Francine Laden

Audrey Jane Gaskins的其他文献

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{{ truncateString('Audrey Jane Gaskins', 18)}}的其他基金

Extreme heat events and fertility: a national study
极端高温事件与生育率:一项全国性研究
  • 批准号:
    10613567
  • 财政年份:
    2022
  • 资助金额:
    $ 24.65万
  • 项目类别:
Extreme heat events and fertility: a national study
极端高温事件与生育率:一项全国性研究
  • 批准号:
    10429519
  • 财政年份:
    2022
  • 资助金额:
    $ 24.65万
  • 项目类别:
The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank
环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响
  • 批准号:
    10457007
  • 财政年份:
    2021
  • 资助金额:
    $ 24.65万
  • 项目类别:
The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank
环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响
  • 批准号:
    10295994
  • 财政年份:
    2021
  • 资助金额:
    $ 24.65万
  • 项目类别:
Maternal Exposure to Air Pollution and Early Pregnancy Outcomes
母亲接触空气污染和早期妊娠结果
  • 批准号:
    10094056
  • 财政年份:
    2019
  • 资助金额:
    $ 24.65万
  • 项目类别:

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