Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.

胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。

基本信息

项目摘要

In the U.S. maternal alcohol use during pregnancy remains an important problem with approximately 10% of women consuming alcohol and 3% reporting binge drinking [1]. Fetal alcohol spectrum disorders (FASD) are the most common preventable cause of birth defects and neurodevelopmental disorders [2]. This problem is accentuated in heavily exposed populations like the Cape Coloured in South Africa, which has one of highest prevalence of FASD in the world [3]. Given the important consequences to child development of this prevalent exposure, it is imperative to identify early-life biomarkers that help identify children with FASD as early as possible so they can receive prompt targeted interventions [4]. This is the aim of the parent R01 study “Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment” (PI Dr. Carter). In Aim 1, the parent study will characterize imprinted gene expression biomarkers in blood and placental tissues from children prenatally exposed to alcohol and controls from the Cape Town longitudinal Cohort Study using RNA-seq. However, placental RNA-seq data to be generated from the parent study are composed of a mix of gene profiles from distinct cell- subtypes within a heterogenous tissue and to date there are no studies addressing this. The aim of the research in this supplement is to leverage recent placenta single-cell RNA-seq to construct a panel of cell-type specific gene makers to disentangle bulk placenta RNAs-seq data from the parent study and assess alcohol-related cell-type specific effects in these data.
在美国,孕妇在怀孕期间饮酒仍然是一个重要的问题 大约10%的女性饮酒,3%的女性报告酗酒[1]。胎儿 酒精谱系障碍(FASD)是导致出生缺陷的最常见的可预防原因 和神经发育障碍[2]。这个问题在被大量曝光的情况下被突出了 像开普省这样的有色人种在南非是发病率最高的国家之一 世界上的FASD[3]。鉴于这种流行的疾病对儿童发展的重要后果 暴露后,必须确定有助于确定患有FASD儿童的早期生物标记物 越早越好,这样他们就能得到及时、有针对性的干预[4]。这就是 父母R01研究《胎儿酒精影响儿童的鉴定:印记基因的改变》 表达和甲基化是神经行为和生长障碍的生物标记物“(PiDr。 卡特)。在目标1中,父母的研究将表征印记基因表达的生物标记物 产前接触酒精的儿童和对照儿童的血液和胎盘组织 开普敦纵向队列研究使用RNA-SEQ。然而,胎盘RNA-seq数据有待于 从父母的研究中产生的基因图谱由不同细胞的基因图谱组成- 异种组织中的亚型,到目前为止还没有研究解决这一问题。 本附录的研究目的是利用最近的胎盘单细胞rna-seq来 构建一组细胞类型特异性基因标记物以解开大量胎盘rna-seq数据 从父母那里研究并评估这些数据中与酒精相关的细胞类型的特定影响。

项目成果

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ROBERT COLIN CARTER其他文献

ROBERT COLIN CARTER的其他文献

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{{ truncateString('ROBERT COLIN CARTER', 18)}}的其他基金

Fetal Neuroprotection by choline supplementation in heavy drinking pregnant women
大量饮酒孕妇补充胆碱对胎儿神经的保护
  • 批准号:
    10583742
  • 财政年份:
    2023
  • 资助金额:
    $ 6万
  • 项目类别:
A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation during Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development
怀孕期间补充胆碱以减轻产前酒精暴露对生长和认知发展的不利影响的随机、双盲、安慰剂对照临床试验
  • 批准号:
    10625834
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation during Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development
怀孕期间补充胆碱以减轻产前酒精暴露对生长和认知发展的不利影响的随机、双盲、安慰剂对照临床试验
  • 批准号:
    10421048
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10443791
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10212186
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    9913250
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10529064
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10023145
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Mediating and Moderating Effects of Fetal Alcohol-Related Iron Deficiency in FASD
胎儿酒精相关缺铁对胎儿酒精谱系障碍 (FASD) 的介导和调节作用
  • 批准号:
    8798553
  • 财政年份:
    2014
  • 资助金额:
    $ 6万
  • 项目类别:
The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans
母体营养在人类酒精致畸中的作用
  • 批准号:
    8530117
  • 财政年份:
    2011
  • 资助金额:
    $ 6万
  • 项目类别:

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