Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.

胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。

基本信息

项目摘要

In the U.S. maternal alcohol use during pregnancy remains an important problem with approximately 10% of women consuming alcohol and 3% reporting binge drinking [1]. Fetal alcohol spectrum disorders (FASD) are the most common preventable cause of birth defects and neurodevelopmental disorders [2]. This problem is accentuated in heavily exposed populations like the Cape Coloured in South Africa, which has one of highest prevalence of FASD in the world [3]. Given the important consequences to child development of this prevalent exposure, it is imperative to identify early-life biomarkers that help identify children with FASD as early as possible so they can receive prompt targeted interventions [4]. This is the aim of the parent R01 study “Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment” (PI Dr. Carter). In Aim 1, the parent study will characterize imprinted gene expression biomarkers in blood and placental tissues from children prenatally exposed to alcohol and controls from the Cape Town longitudinal Cohort Study using RNA-seq. However, placental RNA-seq data to be generated from the parent study are composed of a mix of gene profiles from distinct cell- subtypes within a heterogenous tissue and to date there are no studies addressing this. The aim of the research in this supplement is to leverage recent placenta single-cell RNA-seq to construct a panel of cell-type specific gene makers to disentangle bulk placenta RNAs-seq data from the parent study and assess alcohol-related cell-type specific effects in these data.
在美国,母亲在怀孕期间饮酒仍然是一个重要的问题, 大约10%的女性饮酒,3%的女性报告酗酒[1]。胎儿 酒精谱系障碍(FASD)是出生缺陷最常见的可预防原因 和神经发育障碍[2]。这一问题在严重暴露于 像南非的开普有色人种, 世界上的FASD [3]。考虑到这种流行病对儿童发展的重要影响, 因此,必须确定早期生命生物标志物,以帮助识别FASD儿童 尽早采取有针对性的干预措施[4]。这是我们的目标。 母体R 01研究“胎儿酒精影响儿童的识别:印记基因的改变 表达和甲基化作为神经行为和生长障碍的生物标志物”(PI Dr. Carter)。在目标1中,母研究将表征以下中的印迹基因表达生物标志物: 产前暴露于酒精的儿童的血液和胎盘组织, 使用RNA-seq的开普敦纵向队列研究。然而,胎盘RNA-seq数据将被 从母体研究中产生的基因图谱由来自不同细胞的基因图谱组成, 在异质组织内的亚型,并且迄今为止没有研究解决这个问题。 本补充研究的目的是利用最近的胎盘单细胞RNA-seq, 构建一组细胞类型特异性基因标记以解开大量胎盘RNAs-seq数据 并评估这些数据中酒精相关的细胞类型特异性效应。

项目成果

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ROBERT COLIN CARTER其他文献

ROBERT COLIN CARTER的其他文献

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{{ truncateString('ROBERT COLIN CARTER', 18)}}的其他基金

Fetal Neuroprotection by choline supplementation in heavy drinking pregnant women
大量饮酒孕妇补充胆碱对胎儿神经的保护
  • 批准号:
    10583742
  • 财政年份:
    2023
  • 资助金额:
    $ 6万
  • 项目类别:
A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation during Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development
怀孕期间补充胆碱以减轻产前酒精暴露对生长和认知发展的不利影响的随机、双盲、安慰剂对照临床试验
  • 批准号:
    10625834
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation during Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development
怀孕期间补充胆碱以减轻产前酒精暴露对生长和认知发展的不利影响的随机、双盲、安慰剂对照临床试验
  • 批准号:
    10421048
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10443791
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10212186
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    9913250
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10529064
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.
胎儿酒精影响儿童的鉴定:印记基因表达和甲基化的改变作为神经行为和生长障碍的生物标志物。
  • 批准号:
    10023145
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Mediating and Moderating Effects of Fetal Alcohol-Related Iron Deficiency in FASD
胎儿酒精相关缺铁对胎儿酒精谱系障碍 (FASD) 的介导和调节作用
  • 批准号:
    8798553
  • 财政年份:
    2014
  • 资助金额:
    $ 6万
  • 项目类别:
The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans
母体营养在人类酒精致畸中的作用
  • 批准号:
    8530117
  • 财政年份:
    2011
  • 资助金额:
    $ 6万
  • 项目类别:

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