The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans

母体营养在人类酒精致畸中的作用

基本信息

批准号：
8530117
负责人：
ROBERT COLIN CARTER
金额：
$ 16.84万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8530117
关键词：
Adverse effects Affect Alcohol abuse Alcohols Animal Model Animals Area Behavioral Biological Markers Blinking Body Composition Boston Child Child Nutrition Child health care Childhood Choline Chronic Clinical Clinical Investigator Clinical Research Clinical Sciences Cohort Studies Color Communities DNA Data Analyses Development Diet Dietary Intervention Doctor of Philosophy Emergency Medicine Energy Intake Epigenetic Process Exposure to Faculty Fellowship Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Fetal Alcohol Syndrome Fetal Growth Retardation Fetal alcohol effects Fetus Folate Funding Gastroenterology Genetic Polymorphism Goals Growth Heavy Drinking High Prevalence Histones Homocysteine Homocystine Human Infant Iron Iron deficiency anemia Learning Life Light Measures Mental Retardation Mentored Patient-Oriented Research Career Development Award Mentors Methionine Methylation Micronutrients Neurodevelopmental Deficit Neurodevelopmental Impairment Neurosciences Nutritional Nutritional status Outcome Pediatric Hospitals Perinatal Exposure Physiology Play Polychlorinated Biphenyls Positioning Attribute Pregnant Women Prenatal Nutrition Principal Investigator Process Proteins Psychiatry Public Health Public Health Schools Publishing Research Research Activity Research Personnel Resources Role South Africa Structure Supplementation Teratology Testing Training Training Activity Translating United States National Institutes of Health Universities Vitamin B 12 Weight Gain Woman Work alcohol effect alcohol exposure career cohort conditioning design experience fetal infancy iron deficiency medical schools mother nutrition neurotoxic nutrition offspring patient oriented research postnatal pregnant prenatal prenatal risk factor prevent professor programs prospective skeletal skills skills training success

项目摘要

DESCRIPTION (provided by applicant): This application for a K23 Mentored Patient-Oriented Research Career Development Award details a 5-year plan for training and research activities that will provide the skills and experience I need to achieve success as an independent investigator studying the roles of nutrition in fetal alcohol spectrum disorder (FASD). I am currently in my final academic year of a research fellowship in the Scholars in Clinical Science Program at Harvard Medical School and a clinical fellowship in Pediatric Emergency Medicine at Children's Hospital Boston, where I will begin a faculty position at the start of the proposed funding period. This K23 award will provide me with the support necessary to accomplish the following goals: (1) to assess the nutritional status of heavy drinking pregnant; (2) to examine the impact of maternal nutritional status on fetal alcohol-related growth restriction; (3) to gain expertise in nutritional physiology and alcohol-related teratology that will prepare me to conduct studies examining the roles of pre- and postnatal nutrition in FASD; and finally (4) to gain expertise in planning and executing pediatric patient-oriented research, and thereby develop an independent research career. To achieve these goals, I have assembled a mentoring team comprised of a primary mentor, Christopher Duggan, MD, Director of Clinical Research in the Division of Gastroenterology and Nutrition at Children's Hospital Boston, who conducts research in the fields of pediatric nutrition, gastroenterology, and global child health; and co-mentor Sandra Jacobson, PhD, Professor of Psychiatry and Behavioral Neurosciences at Wayne State University School of Medicine, who has expertise in examining the developmental effects of in utero exposure to neurotoxic agents, most notably alcohol and polychlorinated biphenyls (PCBs). Although it has been widely postulated that maternal nutritional status may interact with prenatal alcohol exposure in FASD, to our knowledge, there have been no published studies in humans examining the nutritional status of heavy drinking pregnant woman or the impact of their nutritional status on the teratogenesis of alcohol. The studies proposed here are designed to test the hypotheses that the nutritional status of heavy drinking pregnant women is poorer than that of women who abstain and that poor maternal nutritional status exacerbates alcohol-related prenatal growth restriction. I will use the resources available to me at Children's Hospital Boston, Harvard Medical School, the Harvard School of Public Health and the University of Cape Town to add these studies to a previously planned, NIH-funded prospective cohort study of heavy drinking pregnant women and abstainers/light-drinkers, focusing on 3 nutritional domains: 1) energy intake and gestational weight gain; 2) iron status; 3) methyl donor status (folate, vitamin B12, choline). These research activities in combination with structured coursework and didactics will give me the training, skills, and hands-on experience needed to develop into an independent investigator with an ongoing research program examining the potential roles of pre- and postnatal nutrition in FASD.

描述（由申请人提供）：本申请K23指导了以患者为导向的研究职业发展奖，详细介绍了一项为期5年的培训和研究活动计划，该计划将为我所需的技能和经验提供成功，作为一个独立研究者，研究营养在胎儿酒精谱系中的作用（FASD）。我目前正在哈佛医学院的临床科学学者研究奖学金研究金，以及波士顿儿童医院的儿科急诊医学临床研究金，在拟议的融资期开始时，我将在那里开始教师职位。该K23奖将为我提供实现以下目标所需的支持：（1）评估重饮酒怀孕的营养状况；（2）检查孕产妇营养状况对胎儿酒精相关的生长限制的影响；（3）获得营养生理学和与酒精相关的培训学方面的专业知识，这将使我做好研究，以研究研究产前和产后营养在FASD中的作用；最后（4）在计划和执行以患者为导向的研究方面获得专业知识，从而发展独立的研究职业。为了实现这些目标，我组建了一支由主要导师组成的指导团队，由一位主要导师Christopher Duggan，医学博士，波士顿儿童医院的胃肠病学和营养部临床研究主任，他在儿科植物，胃肠病学和全球儿童健康领域进行研究；韦恩州立大学医学院的精神病学和行为神经科学教授桑德拉·雅各布森（Sandra Jacobson）博士，他们在检查子宫内暴露于神经毒性药物的发育效果方面具有专业知识，最著名的是酒精和多氯氯的双苯基（PCB）。据我们所知，尽管已经广泛假设，孕产妇营养状况可能与FASD中的产前酒精暴露相互作用，但尚无对人类进行的发表研究，研究了重饮用的孕妇的营养状况或营养状况对酒精致病的影响。此处提出的研究旨在检验以下假设，即饮酒孕妇的营养状况比戒除妇女的营养状况差，而孕产妇营养状况不佳的妇女加剧了与酒精相关的产前生长限制。我将使用波士顿儿童医院，哈佛医学院，哈佛大学公共卫生学院和开普敦大学使用的资源，将这些研究添加到先前计划的，NIH资助的预期的前瞻性队列研究中，研究了重型饮用的孕妇和戒酒者/戒烟者/轻饮者，专注于3个营养域：1）能量插入和遗传体重的体重增加； 2）铁状态； 3）甲基供体状态（叶酸，维生素B12，胆碱）。这些研究活动与结构化的课程和教学能力相结合，将为我提供培训，技能和动手经验，并通过正在进行的研究计划中发展为独立研究人员，研究了FASD前后营养的潜在作用。