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Quantifying the energetic cost of support and stabilization during walking in children with cerebral palsy

量化脑瘫儿童行走过程中支撑和稳定的能量消耗

基本信息

批准号：
10301594
负责人：
Max Donelan
金额：
$ 24.22万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10301594
关键词：
Activities of Daily Living Adult Balance training Biomechanics Carbon Dioxide Cerebral Palsy Child Communities Development Device Designs Devices Eating Fatigue Food Energy Foundations Future Gait Goals Human Impairment Indirect Calorimetry Individual Intervention Jogging Knowledge Lateral Leg Life Limb structure Measures Metabolic Methods Monitor Movement Muscle Nervous System Trauma Operative Surgical Procedures Orthotic Devices Oxygen Participant Pattern Pelvis Performance Population Prevalence Quality of life Recording of previous events Regimen Rehabilitation therapy Reporting Research Research Personnel Research Priority Running Self-Help Devices Speed System Testing Time Training Training Programs Walkers Walking Work biomechanical model cost crouch gait design equilibration disorder evidence base exhaustion exoskeleton experience experimental study fitness improved innovative technologies insight muscle metabolism peer relative cost research and development respiratory gas spasticity strength training theories therapy design walking speed

项目摘要

Project Summary Walking promotes independence, participation, fitness, and exploration in daily life. Like other activities, walking requires metabolic energy from the food we eat, which is ultimately used by our muscles to power movement. Experimentally, we can measure this energy using indirect calorimetry, which monitors oxygen and carbon dioxide as the body converts stored energy into the form used by muscles during activities of daily living. Decades of energetics research has demonstrated that human walking is incredibly efficient. However, for people with cerebral palsy the energetic cost of walking is significantly increased, on average over two times higher than typically-developing individuals. This means that for people with cerebral palsy, walking is as tiring as jogging or climbing stairs. An energetic cost of this magnitude restricts activities of daily living and causes exhaustion. While our team and many others have sought to reduce these costs through surgical interventions, rehabilitation, orthotics, or other assistive devices, these strategies have failed to result in meaningful reductions in energy. To design strategies that successfully reduce walking costs, we must first understand the underlying mechanisms contributing to elevated cost in people with cerebral palsy. The proposed research seeks to fill this knowledge gap by examining biomechanical factors that contribute to elevated energy for people with cerebral palsy. Specifically, we will evaluate the energetic cost of supporting the body (Aim-1) and stabilizing the body (Aim-2) during walking for children with cerebral palsy, and compare these costs to typically-developing peers. These tasks require very little energy during unimpaired walking (e.g., <10% of total walking cost), but their costs remain unknown for people with cerebral palsy and have direct implications for treatment decisions and assistive device design. Building upon decades of energetics research of unimpaired walking, this research will use a mechatronic device to precisely provide support and stabilization assistance during walking and quantify the impact of this assistance on walking cost. In unimpaired adults, similar methods have led to the design of exoskeletons and training programs that effectively reduce walking and running energy. This research will provide the foundation to create evidence-based strategies to decrease energy costs, minimize fatigue, and increase quality of life for people with cerebral palsy and other neurologic injuries.

项目总结