Molecular mechanisms determining the lipid composition of synapses

决定突触脂质组成的分子机制

• 批准号: DP210102837
• 负责人: A/Prof Vladimir Sytnyk
• 金额: $ 34.75万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102837
• 关键词: Molecular; mechanisms; determining; lipid; composition

Synapses between neurons play a key role in all functions of the nervous system including learning and memory. They are mostly composed of the unique combination of proteins and lipids, which function together to enable neurotransmission. While the molecular mechanisms determining the protein composition of synapses are well characterised, the mechanisms defining the lipid composition of synapses remain unknown. The project will use advanced techniques of neuroscience and lipid research to determine the mechanisms of lipid transport and retention at synapses. The project is expected to generate new knowledge about the fundamental mechanisms of brain function, which will be useful for developing new therapeutics enhancing the brain power.

神经元之间的突触在神经系统的所有功能中起着关键作用，包括学习和记忆。它们主要由蛋白质和脂质的独特组合组成，它们共同起作用以实现神经传递。虽然决定突触蛋白质组成的分子机制已得到很好的表征，但定义突触脂质组成的机制仍不清楚。该项目将利用神经科学和脂质研究的先进技术来确定突触处脂质转运和滞留的机制。该项目预计将产生有关大脑功能基本机制的新知识，这将有助于开发增强脑力的新疗法。