Determining the molecular mechanisms of CARM1's role in the maintenance and plasticity of skeletal muscle mass and function

确定 CARM1 在骨骼肌质量和功能的维持和可塑性中作用的分子机制

• 批准号: 479146
• 负责人: Ljubicic Vladimir
• 金额: $ 49.88万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=479146&lang=en
• 关键词: Ampk; Atrophy; Carm1; Exercise; Muscle Mass; Skeletal Muscle

Skeletal muscle wasting caused by nerve damage and disease, or by cancer, is a critical healthcare issue. Unsatisfactory treatments for these conditions are due, in part, to a lack of understanding of the molecular mechanisms responsible for muscle atroph

由神经损伤和疾病或癌症引起的骨骼肌萎缩是一个关键的医疗保健问题。对这些疾病的治疗不令人满意，部分原因是对肌肉萎缩的分子机制缺乏了解。