A Puff Topography Biofeedback Paradigm to Reduce Stress-Precipitated Smoking Reinforcement

减少压力诱发的吸烟强化的抽吸地形生物反馈范例

• 批准号: 10303501
• 负责人: Samantha Gwen Farris
• 金额: $ 25.32万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10303501
• 关键词: Acute; Address; Adult; Affect; Anxiety; Attention; Attenuated; Behavior; Behavioral; Biofeedback; Biofeedback Training; Biological; Blinded; Cardiac; Cigarette; Development; Emotional; Emotions; Etiology; Expectancy; Familiarity; Female; Homeostasis; Impairment; Informal Social Control; Intervention; Intervention Studies; Laboratories; Link; Mediating; Mental disorders; Modeling; Nature; Outcome; Participant; Patient Self-Report; Population; Process; Protocols documentation; Psychological reinforcement; Psychophysiology; Randomized; Recovery; Research; Resistance; Rewards; Sinus; Smoke; Smoker; Smoking; Stress; Testing; Time; Tobacco; United States National Institutes of Health; Visit; addiction; base; behavioral phenotyping; biobehavior; cognitive process; comorbidity; coping; craving; design; emotion regulation; emotional distress; health disparity; high reward; high risk; improved; improved outcome; in vivo monitoring; indexing; innovation; interest; novel; psychologic; respiratory; reward processing; satisfaction; sex; smoking cessation; substance use

PROJECT SUMMARY/ABSTRACT Smokers with emotional distress are particularly vulnerable to smoking reinforcement due to various biopsychological factors that contribute to deficits in emotion regulation and heightened reward processing, which undermine cessation efforts. The timing and intensity of one's puffing (i.e., puff topography) can titrate or maximize the cigarette's rewarding effect. Our group has identified puff topography as a core driver of smoking reinforcement, especially in emotionally distressed smokers. Although largely considered a behavioral phenotype of smoking reinforcement, inherent in puffing behavior are corresponding changes in cardiorespiratory parameters (e.g., cardiac vagal control, CVC) that may promote self-regulation and reduce craving. In our integrated psychophysiological model of emotional distress and smoking, we proposed that in smokers, impaired CVC not only implicates physiological homeostasis, but also influences addiction-relevant processes, including impaired higher-order cognitive processes needed for self-regulation and psychological functioning (e.g., reduced anxiety and stress).Yet, under certain time-sensitive contexts (e.g., stress), emotionally distressed smokers may puff in a way that enhances CVC, resulting in acute self-regulatory benefits, and in turn paradoxically amplifies the reinforcing value of each puff. Thus, a bio-behavioral intervention that could modify puff topography and CVC has the strong potential to reduce the reinforcing value of cigarettes in high-risk emotionally distressed smokers. Grounded in our biobehavioral framework, we designed a highly innovative bio-behavioral paradigm, called Puff Topography Biofeedback Training (PTBT) to directly target putative bio-behavioral underpinnings of smoking reinforcement (i.e., puffing topography and CVC). PTBT leverages in vivo monitoring of respiratory parameters (i.e., biofeedback) that occurs during smoking so that puffing is constrained to a pace that is designed to minimize CVC in order to attenuate acute self-regulatory, emotional, and craving reduction associated with smoking reinforcement. In this R1, we propose a between-subjects experimental test of PTBT and its ability to modify puff topography and CVC during stress-precipitated smoking, and in turn, reduce acute smoking reinforcement. Emotionally distressed daily smokers (N=88, 50% female) will be randomized to PTBT or Control; which are matched for time and attentional demand. Participants will complete two smoking trials on two successive days using either PTBT/Control. The first smoking trial (Visit 1) will allow participants to gain familiarity with the task. The second smoking trial (Visit 2) will be completed following acute laboratory stress induction (stress-precipitated smoking trial). The primary study aims are to test the effect of PTBT vs. Control, in terms of: acute changes in stress- precipitated smoking reinforcement (tobacco demand; cigarette reward; satisfaction) and changes in mechanisms (puff duration, CVC). The results of this high pre-intervention study could inform the subsequent development of a novel intervention strategy for improving quit outcomes in a treatment-resistant population.

项目总结/摘要 有情绪困扰的吸烟者特别容易受到吸烟强化的影响， 导致情绪调节和强化奖励处理缺陷的生物心理因素， 这破坏了停火努力。一个人吸烟的时间和强度（即，抽吸形貌）可以滴定或 最大化香烟的奖励效果。我们的研究小组已经确定了吸烟的核心驱动因素 强化，特别是在情绪困扰的吸烟者。虽然在很大程度上被认为是一种行为 吸烟强化的表型，固有的吸烟行为是相应的变化， 心肺参数（例如，心脏迷走神经控制，CVC），可以促进自我调节， 渴望在我们的情绪困扰和吸烟的综合心理生理模型中，我们提出， 吸烟者，受损的CVC不仅涉及生理稳态，而且还影响成瘾相关的 过程，包括自我调节和心理调节所需的受损高阶认知过程 功能（例如，减少焦虑和压力）。然而，在某些时间敏感的情况下（例如，应力）， 情绪困扰的吸烟者可能以增强CVC的方式吸烟，导致急性自我调节 好处，反过来又矛盾地放大了每一口的强化价值。因此，生物行为 可以改变喷烟形貌和CVC的干预措施具有降低增强值的强大潜力 高风险情绪困扰的吸烟者的香烟。基于我们的生物行为框架，我们 设计了一种高度创新的生物行为模式，称为Puff Topography生物反馈训练（PTBT）， 直接针对吸烟强化的假定生物行为基础（即，膨化地形和 CVC）。PTBT利用呼吸参数的体内监测（即，生物反馈）发生在 吸烟，以便将抽吸限制在设计为最小化CVC的速度，以减轻急性 自我调节，情绪和渴望减少与吸烟强化。在R1中，我们 提出一个PTBT的受试者间实验测试及其修改烟团地形和CVC的能力 在压力诱发的吸烟过程中，反过来，减少急性吸烟强化。悲痛的 每日吸烟者（N = 88，50%女性）将随机分配至PTBT组或对照组;时间和 注意力需求。参与者将在连续两天内完成两次吸烟试验， PTBT/对照。第一次吸烟试验（访视1）将使受试者熟悉这项任务。第二 将在急性实验室应激诱导（应激诱发吸烟）后完成吸烟试验（访视2 审判）。主要研究目的是测试PTBT与对照组的效果，在以下方面：应激的急性变化- 促使吸烟强化（烟草需求;香烟奖励;满意度）和 机制（抽吸持续时间，CVC）。这项高干预前研究的结果可以为随后的研究提供信息。 开发一种新的干预策略，以改善耐药人群的戒烟结果。