Historical social and environmental determinants of memory decline and dementia among U.S. older adults.

美国老年人记忆力衰退和痴呆的历史社会和环境决定因素。

基本信息

  • 批准号:
    10301899
  • 负责人:
  • 金额:
    $ 60.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Incidence of Alzheimer’s disease and related dementias (ADRD) is 40–100% higher among Black compared with White Americans. A key reason for this disparity may include residence in segregated, socially disadvan- taged, and polluted communities. Extant studies suggest that community socioeconomic deprivation is related to decreased brain volume, Alzheimer’s neuropathology, and poor cognitive function, and that fine particulate matter (PM2.5) may contribute to neurodegeneration. Early-life exposures may be particularly important, as early-life community-level disadvantage and ambient air pollution could disrupt the accumulation of cognitive reserve, reduce cognitive resilience, and dampen social trajectories. Community-level social factors and air pollution often co-occur; thus, comprehensive understanding of how these factors operate independently and synergistically requires rigorous evaluation of both. Moreover, identifying the extent to which these factors modify underlying genetic risk—APOE-ε4 genotype and ADRD polygenic risk scores—would inform under- standing of the etiology of ADRD. The overall objective of this application is to evaluate the effects of early-life community-level social and environmental factors on late-life ADRD and the extent to which these factors con- tribute to racial disparities on ADRD in a nationally representative sample. The central hypothesis is that early- life community-level social factors and ambient air pollution have independent and synergistic effects on late- life brain health and ADRD disparities. This project leverages the recently completed data linkage between the 1940 census and the national Health and Retirement Study (HRS) (n≈8,700). Participants in the HRS were an average age of 69 years at first memory assessment between 1995–1998, so HRS includes up to 23 years of longitudinal data on memory scores and dementia, and a subsample also has genotype information. The central hypothesis will be tested in four specific aims among Black and White HRS participants: (1) Investigate the effects of early-life community- level social factors on late-life cognitive health; (2) Examine the effects of early-life ambient air pollution expo- sure on late-life cognitive health; (3) Estimate synergistic effects of early-life community-level social factors and air pollution exposure on late-life cognitive health; and (4) Evaluate the extent to which early-life community- level social factors and exposure to ambient air pollution modify effects of ADRD genetic risk on late-life cogni- tive health. The proposed research is innovative because it assesses joint early-life social and environmental community-level exposures, including via novel air pollution metrics and late-1930s redlining, for ADRD. The proposed work is expected to advance the field by providing new policy-relevant evidence on potential strate- gies to prevent ADRD and eliminate ADRD disparities.
项目总结/文摘

项目成果

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Joan A Casey其他文献

Joan A Casey的其他文献

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{{ truncateString('Joan A Casey', 18)}}的其他基金

2023 Regional ISEE NAC Meeting, Corvallis, OR
2023 年区域 ISEE NAC 会议,俄勒冈州科瓦利斯
  • 批准号:
    10683564
  • 财政年份:
    2023
  • 资助金额:
    $ 60.38万
  • 项目类别:
Short and long-term consequences of wildfires for Alzheimer's disease and related dementias
野火对阿尔茨海默病和相关痴呆症的短期和长期后果
  • 批准号:
    10824706
  • 财政年份:
    2021
  • 资助金额:
    $ 60.38万
  • 项目类别:
Approaches for AI/ML Readiness for Wildfire Exposures.
针对野火暴露的 AI/ML 准备方法。
  • 批准号:
    10593837
  • 财政年份:
    2021
  • 资助金额:
    $ 60.38万
  • 项目类别:
Historical social and environmental determinants of memory decline and dementia among U.S. older adults
美国老年人记忆力下降和痴呆症的历史社会和环境决定因素
  • 批准号:
    10824083
  • 财政年份:
    2021
  • 资助金额:
    $ 60.38万
  • 项目类别:
The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record Approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
  • 批准号:
    10200037
  • 财政年份:
    2019
  • 资助金额:
    $ 60.38万
  • 项目类别:
The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record Approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
  • 批准号:
    10016282
  • 财政年份:
    2019
  • 资助金额:
    $ 60.38万
  • 项目类别:
The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record Approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
  • 批准号:
    9933124
  • 财政年份:
    2019
  • 资助金额:
    $ 60.38万
  • 项目类别:
The impact of unconventional natural gas development on maternal, perinatal, and childhood health: An electronic health record approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
  • 批准号:
    9314971
  • 财政年份:
    2017
  • 资助金额:
    $ 60.38万
  • 项目类别:

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