The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record Approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
基本信息
- 批准号:10200037
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:Acute respiratory infectionAddressAffectAgeAirAir PollutantsAir PollutionAnxietyAsthmaAwardBiological ModelsBirthBirth WeightCaringCatchment AreaChemicalsChildChild CareChild HealthChildhoodChildhood AsthmaChronicCodeCohort StudiesComplexDataData CollectionDevelopmentDiagnosisElectronic Health RecordEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEnvironmental HealthEnvironmental PolicyEnvironmental Risk FactorExposure toGeographic Information SystemsGeographyGestational DiabetesGoalsHealthHealth systemHealthcare SystemsHospitalsHypertensionInfant CareInflammationInjuryInstitutionInterdisciplinary StudyIrritantsJointsLinkLogisticsLongevityMaternal HealthMaternal and Child HealthMeasuresMediatingMediationMediator of activation proteinMental DepressionMethodsMissionModelingMothersNational Institute of Environmental Health SciencesNatural GasNatureNeonatalOutcomeOutcome StudyParticulate MatterPathway interactionsPennsylvaniaPerinatalPhasePoliciesPolicy MakingPopulation HeterogeneityPovertyPregnancyPremature BirthPrimary Health CareProductionPsychological StressPublic HealthQuestionnairesRaceReadingReportingResearchRespiratory SystemRisk FactorsSleep DisordersSocioeconomic StatusStressTechnologyTerm BirthTimeTrainingWorkadverse birth outcomesair monitoringair samplingapprenticeshipasthma exacerbationbasebioinformatics toolcareerdata miningdesignearly childhoodelectronic dataelementary schoolenvironmental stressorepidemiology studyexperienceexperimental studyhealth dataimprovedin uteroneonatal healthpediatric patientspopulation healthpsychosocialrespiratoryrespiratory healthskillssocialsocial determinantssocial factorssocial stresssocial stressorstressorstudy populationtext searchingvolatile organic compound
项目摘要
PROJECT SUMMARY/ABSTRACT
Recent studies have linked unconventional natural gas development (UNGD) to adverse birth outcomes. The
relative contributions of specific risk factors, such as related air pollutants, socioeconomic status, and maternal
health during pregnancy, however, remain unclear, as do the consequences of UNGD for childhood health.
The objective of this K99/R00 application is to use UNGD in Pennsylvania as a model system–because it repre-
sents a rapid, widespread social experiment with chemical and psychosocial exposures and as well as communi-
ty changes–to disentangle the effects of environmental and social co-exposures on maternal, neonatal, and child
health. The proposed project will link UNGD activity to mothers' electronic health records (EHRs) in combination
with primary data collected by questionnaires, passive air samplers, and geographic information systems. EHR
data are particularly well suited for environmental health research because they provide inexpensive access to
longitudinal health data on large and diverse populations (i.e., in terms of age, socioeconomic status, race, and
geography). Considerable logistical and analytic skills are required to optimize use of EHR data, supplement it
with primary data collection, and complete causal analyses. The K99 is designed to augment the candidate's
prior research experience through coursework, apprenticeships in environmental epidemiology, and directed
readings, with specific training in: (1) maternal and child health; (2) EHR text mining; (3) causal mediation
analysis; (4) primary data collection; and (5) analysis of co-exposures. The skills gained during this award are
critical to the long-term goal to use EHR data from multiple healthcare systems to conduct environmental epi-
demiology studies across the lifecourse, in order to inform environmental policy-making. The proposed research
will utilize Geisinger Health System's EHR data, which provides access to >15,000 births that have spatial and
temporal overlap with UNGD in Pennsylvania. Aim 1 (K99 phase) combines text mining strategies and diagnosis
codes to extract mothers' pregnancy-related health conditions from EHR data and then applies causal inference
methods to evaluate pregnancy-related hypertension, gestational diabetes, sleep disorders, depression, and anx-
iety as mediators of the observed associations between UNGD and term birth weight and preterm birth. Aim 2
(K99 phase) pilots primary data collection of chronic social stressors via questionnaires and ambient air samples
near elementary schools attended by Geisinger pediatric patients. The R00 phase builds upon K99 data collec-
tion and follows the primary care infants until 2021 (ages 8-15 years) to evaluate associations of types and timing
of UNGD activity in relation to asthma diagnosis and acute respiratory infection. Aims 3-4 (R00 phase) begin to
disentangle the environmental and social determinants of childhood respiratory outcomes. The proposal ad-
dresses logistical and analytic challenges in environmental epidemiology and will prepare the applicant for an
independent research career. This work will evaluate joint effects of environmental and social stressors on health
across the lifespan and advance use of EHR data in environmental epidemiology.
项目总结/文摘
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Naming Civic Health in Environmental Justice Discourse: The Jackson Water Crisis.
在环境正义话语中命名公民健康:杰克逊水危机。
- DOI:10.1016/j.lana.2022.100378
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Nwanaji-Enwerem,JamajiC;Casey,JoanA
- 通讯作者:Casey,JoanA
Historic redlining and the siting of oil and gas wells in the United States.
- DOI:10.1038/s41370-022-00434-9
- 发表时间:2023-01
- 期刊:
- 影响因子:4.5
- 作者:Gonzalez, David J. X.;Nardone, Anthony;Nguyen, Andrew, V;Morello-Frosch, Rachel;Casey, Joan A.
- 通讯作者:Casey, Joan A.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Joan A Casey其他文献
Joan A Casey的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Joan A Casey', 18)}}的其他基金
2023 Regional ISEE NAC Meeting, Corvallis, OR
2023 年区域 ISEE NAC 会议,俄勒冈州科瓦利斯
- 批准号:
10683564 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Short and long-term consequences of wildfires for Alzheimer's disease and related dementias
野火对阿尔茨海默病和相关痴呆症的短期和长期后果
- 批准号:
10824706 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Historical social and environmental determinants of memory decline and dementia among U.S. older adults.
美国老年人记忆力衰退和痴呆的历史社会和环境决定因素。
- 批准号:
10301899 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Approaches for AI/ML Readiness for Wildfire Exposures.
针对野火暴露的 AI/ML 准备方法。
- 批准号:
10593837 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Historical social and environmental determinants of memory decline and dementia among U.S. older adults
美国老年人记忆力下降和痴呆症的历史社会和环境决定因素
- 批准号:
10824083 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record Approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
- 批准号:
10016282 - 财政年份:2019
- 资助金额:
$ 24.9万 - 项目类别:
The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record Approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
- 批准号:
9933124 - 财政年份:2019
- 资助金额:
$ 24.9万 - 项目类别:
The impact of unconventional natural gas development on maternal, perinatal, and childhood health: An electronic health record approach
非常规天然气开发对孕产妇、围产期和儿童健康的影响:电子健康记录方法
- 批准号:
9314971 - 财政年份:2017
- 资助金额:
$ 24.9万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Research Grant