Gestational Diabetes Mellitus, Perinatal Depression, and Offspring Neurodevelopmental Phenotype

项目摘要 本K99应用旨在确定妊娠期糖尿病（GDM）和产前糖尿病的途径。 抑郁症影响产后母亲的心理健康、新生儿的脑功能和幼儿的脑行为 发展妊娠期糖尿病与抑郁症之间存在双向关联，其影响程度约为 在美国，分别有10%和13%的女性患有这种疾病， 少数民族群体。这两种情况都独立地与不良的神经发育有关。 对后代的影响包括社交情绪和注意力缺陷的风险增加。尽管

PROJECT SUMMARY This K99 application aims to determine pathways by which gestational diabetes mellitus (GDM) and prenatal depression affect postpartum maternal mental health, neonatal brain function, and toddler brain-behavioral development. There is a bidirectional association between GDM and depression which affect approximately 10% and 13% of women in the United States respectively and disproportionately affect women from ethnic and racial minority groups. Both conditions are independently associated with adverse neurodevelopmental outcomes in offspring including increased risk for social-emotional and attentional deficits. Despite the